Protein Alignment CG12288 and HNRNPM

DIOPT Version :10

• Sequence 1: NP_609822.1
• Gene: CG12288 / 35027
• FlyBaseID: FBgn0032620
• Length: 435
• Species: Drosophila melanogaster
• Sequence 2: NP_005959.2
• Gene: HNRNPM / 4670
• HGNCID: 5046
• Length: 730
• Species: Homo sapiens
• Alignment Length: 292
• Identity: 72/292 - (24%)
• Similarity: 111/292 - (38%)
• Gaps: 76/292 - (26%)

  Fly    97 EAQVKVESKATKKEKVEKEP-----TTAPNEKPKGKVSKKAKANANNKDEEGVKRIRNPAEEAST 156
            ||..:|.:...|.|:....|     ..||.  |||:..:.|: |...| |:.:||..|..|..:.
Human     6 EAAAEVAATEIKMEEESGAPGVPSGNGAPG--PKGEGERPAQ-NEKRK-EKNIKRGGNRFEPYAN 66

  Fly   157 ------VFVGNLPINTKRVQLVKLF-QPYGLVQSIR-LRTAGGKQL------FKHKQ--RKVAGS 205
                  .|:.|:|.:.|...|..|. :..|.|..:. |..|.||..      ||.::  :|.|..
Human    67 PTKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAEGKSRGCAVVEFKMEESMKKAAEV 131

  Fly   206 LNAYVVLEKP---------EIAQQAL-------------------------ALNGSEFKENHLRV 236
            ||.:.:..:|         |.|::|:                         .||......   .:
Human   132 LNKHSLSGRPLKVKEDPDGEHARRAMQKVMATTGGMGMGPGGPGMITIPPSILNNPNIPN---EI 193

  Fly   237 TPASMAEKFGQAKDKQPSDKDAKRTIFVGSLKYSATEEQLREIFSSCGEIDYIRCLQDGDKGCKG 301
            ..|..|.:.|.             |:||.:|.|....::|:|:||..|.:.....|:|.|...:|
Human   194 IHALQAGRLGS-------------TVFVANLDYKVGWKKLKEVFSMAGVVVRADILEDKDGKSRG 245

  Fly   302 VAYVCF-QKPDAVGLALELNQTLLDDRPINVE 332
            :..|.| |..:||......|..||.|||::|:
Human   246 IGTVTFEQSIEAVQAISMFNGQLLFDRPMHVK 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12288	NP_609822.1	RRM1_RBM34	156..237	CDD:409828	24/130 (18%)
		RRM_SF	261..332	CDD:473069	25/71 (35%)
HNRNPM	NP_005959.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..62		18/59 (31%)
		HnRNP_M_NLS	41..70	CDD:463289	8/30 (27%)
		RRM1_hnRNPM	72..147	CDD:410058	19/74 (26%)
		RRM2_hnRNPM	204..279	CDD:410060	26/87 (30%)
		27 X 6 AA repeats of [GEVSTPAN]-[ILMV]-[DE]-[RH]-[MLVI]-[GAV]	400..608
		RRM3_hnRNPM	654..730	CDD:410062