DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12288 and nop12

DIOPT Version :9

Sequence 1:	NP_609822.1	Gene:	CG12288 / 35027	FlyBaseID:	FBgn0032620	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_594218.1	Gene:	nop12 / 2542314	PomBaseID:	SPAC16E8.06c	Length:	438	Species:	Schizosaccharomyces pombe

Alignment Length:	434	Identity:	124/434 - (28%)
Similarity:	202/434 - (46%)	Gaps:	67/434 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SKTKP------KKKTVKVPKD-EVKAA--VQESPKKLSA--KDLAKIEKKKAKKQAQKLKKQQNK 86
            |::||      |:.||...|| ||:.|  |:|:.:.:.:  |::..| |.|:||:.:||....:.
pombe    34 SQSKPIPKPVAKETTVLTKKDVEVEEANGVEEAAETIESDTKEVQNI-KPKSKKKKKKLNDSSDD 97

  Fly    87 LAPK---EIKTEPEAQVKVESKATKKEKVEKEPTTAPNEKPKGKVSKKAKANANNKDE-EGVKRI 147
            :..|   |:..|.:.:...:|.....::.:|.|.       |..|.::..:..:.|.| |..:::
pombe    98 IEGKYFEELLAEEDEEKDKDSAGLINDEEDKSPA-------KQSVLEERTSQEDVKSEREVAEKL 155

  Fly   148 RNPAEEA-STVFVGNLP--INTKR---VQLVKLFQPYGLVQSIRLRTAGGKQ-------LFKHKQ 199
            .|..|:: .||||.|||  :.|.:   ..|.|.|:.:|.|.|||.|:....:       .|:.|.
pombe   156 ANELEKSDKTVFVNNLPARVVTNKGDYKDLTKHFRQFGAVDSIRFRSLAFSEAIPRKVAFFEKKF 220

  Fly   200 RKVAGSLNAYVVLEKPEIAQQALALNGSEFKENHLRVTPASMAEKFGQAKDKQPSDKDAKRTIFV 264
            .....::|||:|......|:.||:|||:.|.:.||||...|           .|..:|.||.:||
pombe   221 HSERDTVNAYIVFRDSSSARSALSLNGTMFMDRHLRVDSVS-----------HPMPQDTKRCVFV 274

  Fly   265 GSLKYSATEEQLREIFSSCGEIDYIRCLQDGDKGC-KGVAYVCFQKPDAVGLALELNQTLLDDRP 328
            |:|.:.|.||.|...|..||.|||:|.::|..... ||.||:.|:....|..||.||:..:.:
pombe   275 GNLAFEAEEEPLWRYFGDCGSIDYVRIVRDPKTNLGKGFAYIQFKDTMGVDKALLLNEKKMPE-- 337

  Fly   329 INVERYQVKKLGAKQVRDAAAASAASKTSSKTKAKNQNSAGAKKRLDKKKGKE-NGSLKKEGAPT 392
                        .:.:|...|.|...|:.:::|..::.:...:.|..|..||. |..|::|.|..
pombe   338 ------------GRTLRIMRAKSTKPKSITRSKRGDEKTRTLQGRARKLIGKAGNALLQQELALE 390

  Fly   393 GQKKKSEYRGVKVDGIKKA-KKPKKKSNDQQTALAKKIAPKQKS 435
            |.:.|.   |......||. ||.|:::...:...|:.:..|||:
pombe   391 GHRAKP---GENPLAKKKVNKKRKERAAQWRNKKAESVGKKQKT 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12288	NP_609822.1	RRM1_RBM34	155..237	CDD:240840	33/93 (35%)
CG12288	NP_609822.1	RRM_SF	261..332	CDD:302621	26/71 (37%)
nop12	NP_594218.1	RRM	71..350	CDD:223796	89/311 (29%)
		RRM1_Nop12p_like	164..263	CDD:241113	35/109 (32%)
		RRM2_Nop12p_like	271..347	CDD:241114	27/89 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	121	1.000	Inparanoid score	I1493
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004008
OrthoInspector	1	1.000	-	-		oto101509
orthoMCL	1	0.900	-	-		OOG6_103046
Panther	1	1.100	-	-	O	PTHR23236
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R827
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.950