DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12288 and RBM34

DIOPT Version :9

Sequence 1:	NP_609822.1	Gene:	CG12288 / 35027	FlyBaseID:	FBgn0032620	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_055829.2	Gene:	RBM34 / 23029	HGNCID:	28965	Length:	430	Species:	Homo sapiens

Alignment Length:	432	Identity:	132/432 - (30%)
Similarity:	192/432 - (44%)	Gaps:	107/432 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KTPKAKESEKAEL--KPIKKEPGVVEDGKVTKKSKTKPKKKTVKVPKDEVKAAVQESPKKLSAKD 64
            ||.:.:|.|....  :|:.:||.          .|.|.|||.....|   |.|.:||  .|::.|
Human    81 KTKRNEEEESTSQIERPLSQEPA----------KKVKAKKKHTNAEK---KLADRES--ALASAD 130

  Fly    65 LAKIEKKKAKKQAQKLKKQQN--KLAPKEIKTEPEAQVKVESKATKKEKVEKEPTTAPNEKPKGK 127
            |   |::..:||.||.|..|.  |:|.::|..:.|..|
Human   131 L---EEEIHQKQGQKRKNSQPGVKVADRKILDDTEDTV--------------------------- 165

  Fly   128 VSKKAKANANNKDEEGVKRIRNPAEEASTVFVGNLPINTKRVQLVKLFQPYGLVQSIRLRT---A 189
            ||::.|...|.::|    |::|    ..||||||||:...:.:|...|:.||.::|:|.|:   |
Human   166 VSQRKKIQINQEEE----RLKN----ERTVFVGNLPVTCNKKKLKSFFKEYGQIESVRFRSLIPA 222

  Fly   190 GG---KQL--FKHKQRKVAGSLNAYVVLEKPEIAQQALALNGSEFKEN-HLRVTPASMAEKFGQA 248
            .|   |:|  .|.|......::|||||.::...|.|||..||::..:. .:||..||
Human   223 EGTLSKKLAAIKRKIHPDQKNINAYVVFKEESAATQALKRNGAQIADGFRIRVDLAS-------- 279

  Fly   249 KDKQPSDKDAKRTIFVGSLKYSATEEQLREIFSSCGEIDYIRCLQDGDKGC-KGVAYVCFQKPDA 312
               :.|.:| ||::|||:|.|...|..:.:.|..||.|..:|.::|...|. ||..||.|:..|:
Human   280 ---ETSSRD-KRSVFVGNLPYKVEESAIEKHFLDCGSIMAVRIVRDKMTGIGKGFGYVLFENTDS 340

  Fly   313 VGLALELNQTLLDDRPINVERYQVKKLGAKQVRDAAAASAASKTSSKTKAKNQNSAGAKKRLDK- 376
            |.|||:||.:.|..|.:.|.|                      :.:|.|.|.|||....|.:.|
Human   341 VHLALKLNNSELMGRKLRVMR----------------------SVNKEKFKQQNSNPRLKNVSKP 383

  Fly   377 KKGKENGSLKKEGAPTGQKKKSEYRGVKVDGIKKAKKPKKKS 418
            |:|....|...||.|     ||.:.|.|...:|..||.:|||
Human   384 KQGLNFTSKTAEGHP-----KSLFIGEKAVLLKTKKKGQKKS 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12288	NP_609822.1	RRM1_RBM34	155..237	CDD:240840	33/90 (37%)
CG12288	NP_609822.1	RRM_SF	261..332	CDD:302621	27/71 (38%)
RBM34	NP_055829.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..123		15/54 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..153		7/18 (39%)
		RRM	176..>382	CDD:223796	79/247 (32%)
		RRM1_RBM34	185..276	CDD:240840	33/90 (37%)
		RRM2_RBM34	288..360	CDD:240841	27/71 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..395		11/29 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..430		6/10 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BIWG
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	124	1.000	Inparanoid score	I4728
Isobase	1	0.950	-	0	Normalized mean entropy	S2864
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004008
OrthoInspector	1	1.000	-	-		oto90470
orthoMCL	1	0.900	-	-		OOG6_103046
Panther	1	1.100	-	-	O	PTHR23236
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R827
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.800