DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12288 and rbm-34

DIOPT Version :9

Sequence 1:	NP_609822.1	Gene:	CG12288 / 35027	FlyBaseID:	FBgn0032620	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_502291.1	Gene:	rbm-34 / 178148	WormBaseID:	WBGene00008688	Length:	394	Species:	Caenorhabditis elegans

Alignment Length:	443	Identity:	121/443 - (27%)
Similarity:	189/443 - (42%)	Gaps:	88/443 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 KKEPGVVEDGKVTKKSKTKPKKKTVKVP-----------------KDEVKAAVQESPKKLSAKDL 65
            :|...|..|.:...::..|.||:...:|                 |....|||||.    ..|..
Worm     8 RKAEAVSADAEAVAEAPKKIKKQKPSLPVSEPDNYQAGGLSSLFGKSSEGAAVQEE----VVKGD 68

  Fly    66 AKIEKKKAKKQAQKLKKQQNKLAPKEIKTEPEAQVKVESKATKKEKVEKEPTTAPNEKPKGKVSK 130
            ..|||.|.:|...|.|.::.|.|......|   :|..|::..:|:...||......::.:.:..:
Worm    69 KVIEKPKRRKYDPKKKAEEEKAADAAAAAE---EVAPETEGEEKKDENKEGKRDRTKQRENRTLQ 130

  Fly   131 KAKANANNKDEEGVKRIRNPAEEASTVFVGNLPINTKRVQLVKLFQPYGLVQSIRLRT--AGGKQ 193
            |:.|.|            :.||.|.||||||:|:......:.::|..:|.:.|:|:|.  ...::
Worm   131 KSNARA------------SAAENALTVFVGNMPLTMNEKSVRRIFSDFGTISSVRMRNLLPANEK 183

  Fly   194 LFKH------KQRKVAGSLNAYVVLEKPEIAQQALALNGSEFKENHLRVTPASMAEKFGQAKDKQ 252
            |.|.      |......||..||.....|..::||..||::..::.:||      :|.|..|.:.
Worm   184 LTKRVTHLTGKLNDKQSSLTFYVKFGAEESVEKALKYNGTKLDDHVIRV------DKVGSKKKEF 242

  Fly   253 PSDKDAKRTIFVGSLKYSATEEQLREIFSS-CGEIDYIRCLQDGDKG-CKGVAYVCFQKPDAVGL 315
            ..|    ..||||:|.:..||:.|...||: .|.::.:|.::|.|.| .||.|:|.|::..:|.|
Worm   243 GKD----MAIFVGNLPFEITEDALITFFSAQIGPVEAVRIVRDKDTGKGKGFAFVNFKQDSSVSL 303

  Fly   316 ALELNQTLLDDRPINVERYQVKKLGAKQVRDAAAASAASKTSSKTKAKNQNSAGAKKRLDKKKGK 380
            ||.:....::.|.:.:.:  |.|.|     .......|.|.:|..| ||||....|  |.|.|
Worm   304 ALSMETIKMEKRDLRITK--VMKKG-----HLTKIQTAKKRTSHGK-KNQNEITGK--LHKFK-- 356

  Fly   381 ENGSLKKEGAPTGQKKKSEYRGVKVDGIKKAKKPKKKSNDQQTALAKKIAPKQ 433
              .|.|||..    .::::.|.:|    |.|||          |:|||.|.|:
Worm   357 --FSTKKERT----TEQNDRRALK----KSAKK----------AIAKKKAAKK 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12288	NP_609822.1	RRM1_RBM34	155..237	CDD:240840	25/89 (28%)
CG12288	NP_609822.1	RRM_SF	261..332	CDD:302621	25/72 (35%)
rbm-34	NP_502291.1	RRM1_RBM34	144..233	CDD:240840	26/94 (28%)
rbm-34	NP_502291.1	RRM2_RBM34	247..320	CDD:240841	25/72 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BIWG
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	103	1.000	Inparanoid score	I3540
Isobase	1	0.950	-	0	Normalized mean entropy	S2864
OMA	1	1.010	-	-		QHG55893
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004008
OrthoInspector	1	1.000	-	-		oto17284
orthoMCL	1	0.900	-	-		OOG6_103046
Panther	1	1.100	-	-	O	PTHR23236
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R827
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.810