DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12288 and HNRNPA1L2

DIOPT Version :9

Sequence 1:	NP_609822.1	Gene:	CG12288 / 35027	FlyBaseID:	FBgn0032620	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_001011724.1	Gene:	HNRNPA1L2 / 144983	HGNCID:	27067	Length:	320	Species:	Homo sapiens

Alignment Length:	275	Identity:	63/275 - (22%)
Similarity:	102/275 - (37%)	Gaps:	46/275 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 NANNKDEEGVKRIRNPAEEASTVFVGNLPINTKRVQLVKLFQPYG-LVQSIRLRTAGGKQLFKHK 198
            :|:.|:.|.::::          |:|.|...|....|...|:.:| |...:.:|....|
Human     4 SASPKEPEQLRKL----------FIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTK------ 52

  Fly   199 QRKVAGSLNAYVVLEKPEIAQQALALNGSEFKENHLRVTPASMAEKFGQAKDKQ-PSDKDAKRTI 262
             |........|..:|:.:     .|:|.:..|.:...|.|.....:    :|.| |......:.|
Human    53 -RSRGFGFVTYATVEEVD-----AAMNTTPHKVDGRVVEPKRAVSR----EDSQRPGAHLTVKKI 107

  Fly   263 FVGSLKYSATEEQLREIFSSCGEIDYIRCLQDGDKGCK-GVAYVCFQKPDAVGLALELNQTLLDD 326
            |||.:|....|..||:.|...|:|:.|..:.|...|.| |.|:|.|...|:|            |
Human   108 FVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSV------------D 160

  Fly   327 RPINVERYQVKKLGAKQVRDAAAASAASKTSSKTKAKNQNSAGAKKRLDKKKGKEN----GSLKK 387
            : |.:::|...|....:||.|......:..||..:.:..:......|.|...|.:|    |:...
Human   161 K-IVIQKYHTVKGHNCEVRKALPKQEMASASSSQRGRRGSGNFGGGRGDGFGGNDNFGRGGNFSG 224

  Fly   388 EGAPTGQKKKSEYRG 402
            .|...|......|.|
Human   225 RGGFGGSCGGGGYGG 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12288	NP_609822.1	RRM1_RBM34	155..237	CDD:240840	16/82 (20%)
CG12288	NP_609822.1	RRM_SF	261..332	CDD:302621	23/71 (32%)
HNRNPA1L2	NP_001011724.1	Globular A domain	4..94		21/115 (18%)
		RRM1_hnRNPA1	12..92	CDD:410154	18/101 (18%)
		Globular B domain	95..185		30/102 (29%)
		RRM_SF	105..184	CDD:418427	28/91 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	181..216		5/34 (15%)
		RNA-binding RGG-box	218..240		5/22 (23%)
		HnRNPA1	255..292	CDD:402981
		Nuclear targeting sequence. /evidence=ECO:0000250	268..305
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	271..320
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910