DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12288 and AgaP_AGAP000029

DIOPT Version :9

Sequence 1:	NP_609822.1	Gene:	CG12288 / 35027	FlyBaseID:	FBgn0032620	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	XP_311133.5	Gene:	AgaP_AGAP000029 / 1272249	VectorBaseID:	AGAP000029	Length:	4121	Species:	Anopheles gambiae

Alignment Length:	446	Identity:	90/446 - (20%)
Similarity:	152/446 - (34%)	Gaps:	154/446 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ESEKAELKPIKKE---PGVVEDGKVTKKSKTKPKKKTVKVPKDEVKAAVQESPKKL--SAKDLAK 67
            :..|.:..|::|:   ||:.:|||..::..|:.|.......:|:.|.....|.||.  .|||.|
Mosquito   996 DMNKQKTDPLQKDLRLPGIEQDGKDGQRDATEQKDHLDHSEQDKTKQTDDASEKKTQPEAKDGA- 1059

  Fly    68 IEKKKAKKQAQKLKKQQNKLAPKEIKTEPEAQVKVESKATKKEKVEKEPTTAPNEKPKGKVSKKA 132
                            .|....||:..:.:.:|   .|:..|:.:.|..:::|.....|.::..|
Mosquito  1060 ----------------TNHDGSKELSDKQQEKV---DKSDHKDGLTKGGSSSPAIVDSGTLADAA 1105

  Fly   133 KANANNKDEEGVKRIRNPAEEASTVFVGNLPINTKRVQLVKLFQPYGLVQSIRLRTAGGKQLFKH 197
            .:...:.|::  |..:..|::|                                 |..||:....
Mosquito  1106 TSQGESSDQD--KNDQKDAKDA---------------------------------TQDGKEQHHD 1135

  Fly   198 KQRKVAGSLNAYVVLE--KPEIAQQALALNGSEFKENHLRVTPASMAEKFGQAKDKQPSDKDAKR 260
            ||:.         .||  |.:.|.||      |.||          .:..|.|..:|..||.
Mosquito  1136 KQQD---------TLEPAKGDDASQA------EQKE----------GKADGLADQQQQQDKK--- 1172

  Fly   261 TIFVGSLKYSATEEQLREIFSSCGEIDYIRCLQDGDKGCKGVAYVCFQKPDAVGLALELNQTLLD 325
                   :.|.||.:.::  :..||   .:..||              ||....|..::.....:
Mosquito  1173 -------EQSETESKSQD--AGAGE---AKDQQD--------------KPSGESLDHKMADGTAE 1211

  Fly   326 DRPINVERYQVKKLGAKQVRDAAAASAASKTSSK---TKAKNQNSAGAKKRLDK-KKGKENGSLK 386
            .:....::.|..:.|       ||:.||:..|.|   :::.:|.||..:...|| ..|||:.  :
Mosquito  1212 GKAALDKKQQPGETG-------AASDAATDQSEKKPESQSPDQTSATGEPLPDKLDGGKEDA--Q 1267

  Fly   387 KEGAPTGQKKKSEYRGVKVDGIKKAK---------------------KPKKKSNDQ 421
            |:.:.....|..|.    .||:.||.                     |||..:.||
Mosquito  1268 KDASSNSASKADEL----ADGLSKASSSLPLADSGLEDASKLLKSDDKPKLPTVDQ 1319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12288	NP_609822.1	RRM1_RBM34	155..237	CDD:240840	14/83 (17%)
CG12288	NP_609822.1	RRM_SF	261..332	CDD:302621	10/70 (14%)
AgaP_AGAP000029	XP_311133.5	zf-TAZ	354..421	CDD:280324
		DMP1	<1017..1291	CDD:284637	80/395 (20%)
		Neuromodulin	1194..1388	CDD:284117	32/153 (21%)
		KIX	1831..1909	CDD:280354
		PHA03255	2283..>2423	CDD:165513
		Bromo_cbp_like	2605..2712	CDD:99927
		RING_CBP-p300	2724..2796	CDD:276805
		PHD_CBP_p300	2798..2829	CDD:277032
		HAT_KAT11	2860..3171	CDD:285432
		ZZ_CBP	3227..3267	CDD:239077
		ZnF_TAZ	3292..3364	CDD:214717
		Creb_binding	3640..3721	CDD:286163
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910