DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12288 and U2AF2

DIOPT Version :9

Sequence 1:	NP_609822.1	Gene:	CG12288 / 35027	FlyBaseID:	FBgn0032620	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_009210.1	Gene:	U2AF2 / 11338	HGNCID:	23156	Length:	475	Species:	Homo sapiens

Alignment Length:	375	Identity:	69/375 - (18%)
Similarity:	138/375 - (36%)	Gaps:	90/375 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 DEVKAAVQESP----------KKLSAKDLAKIEKKKAKKQAQKLKKQQNKLAPKEIKTEPEAQVK 101
            ||.:..:.|:.          |:..::..::..|::::.:.::.:.|::....:..:::|..:..
Human     5 DEFERQLNENKQERDKENRHRKRSHSRSRSRDRKRRSRSRDRRNRDQRSASRDRRRRSKPLTRGA 69

  Fly   102 VES--------KATKKEKVEK------------EPTTAPNEKPKGKVSKKAKANANNKDEEGVKR 146
            .|.        :..||:||.|            .|......:..|::...|.......|...|..
Human    70 KEEHGGLIRSPRHEKKKKVRKYWDVPPPGFEHITPMQYKAMQAAGQIPATALLPTMTPDGLAVTP 134

  Fly   147 IRNP------AEEASTVFVGNLPINTKRVQLVKLFQPY----GLVQSIRLRTAGGKQLFKHKQRK 201
            ...|      ..:|..::|||:|.......::..|...    ||.|      |.|..:
Human   135 TPVPVVGSQMTRQARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQ------APGNPV------- 186

  Fly   202 VAGSLN-----AYVVLEKPEIAQQALALNGSEFKENHLRVTPASMAEKFGQAKDKQP----SDK- 256
            :|..:|     |::.....:...||:|.:|..|:...|::.         :..|.||    |:.
Human   187 LAVQINQDKNFAFLEFRSVDETTQAMAFDGIIFQGQSLKIR---------RPHDYQPLPGMSENP 242

  Fly   257 -------------DAKRTIFVGSLKYSATEEQLREIFSSCGEIDYIRCLQDGDKG-CKGVAYVCF 307
                         |:...:|:|.|.....::|::|:.:|.|.:.....::|...| .||.|:..:
Human   243 SVYVPGVVSTVVPDSAHKLFIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEY 307

  Fly   308 QKPDAVGLALE-LNQTLLDDRPINVERYQVKKLGAKQVRDAAAASAASKT 356
            ...:....|:. ||...|.|:.:.|:|..|   |||.....:..|..::|
Human   308 VDINVTDQAIAGLNGMQLGDKKLLVQRASV---GAKNATLVSPPSTINQT 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12288	NP_609822.1	RRM1_RBM34	155..237	CDD:240840	19/90 (21%)
CG12288	NP_609822.1	RRM_SF	261..332	CDD:302621	17/72 (24%)
U2AF2	NP_009210.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..90		12/84 (14%)
		Required for interaction with PRPF19. /evidence=ECO:0000269\|PubMed:21536736	2..93		13/87 (15%)
		Necessary and sufficient to stimulate pre-mRNAs 3'-end cleavage in a CFIm complex-dependent manner. /evidence=ECO:0000269\|PubMed:17024186	17..47		2/29 (7%)
		U2AF_lg	63..474	CDD:273727	63/317 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910