Protein Alignment CG12288 and SYNCRIP

DIOPT Version :10

• Sequence 1: NP_609822.1
• Gene: CG12288 / 35027
• FlyBaseID: FBgn0032620
• Length: 435
• Species: Drosophila melanogaster
• Sequence 2: NP_006363.4
• Gene: SYNCRIP / 10492
• HGNCID: 16918
• Length: 623
• Species: Homo sapiens
• Alignment Length: 432
• Identity: 94/432 - (21%)
• Similarity: 152/432 - (35%)
• Gaps: 135/432 - (31%)

  Fly    46 KDEVKAAVQESPKKLSAKDLAKIEKKKA-----KKQAQKLKKQQNKLAPKEIKTEPEAQVKVESK 105
            :|...|.:|:    ....||:.::.|.|     .|..::.:||..|:|... |...||::|.
Human    70 EDGALAVLQQ----FKDSDLSHVQNKSAFLCGVMKTYRQREKQGTKVADSS-KGPDEAKIKA--- 126

  Fly   106 ATKKEKVEKEPTTAPNEKPKGKVSKKAKANANNKDEEGVKRIRNPAEEA----------STVFVG 160
            ..::.....:.||                        |.::...|..::          :.:|||
Human   127 LLERTGYTLDVTT------------------------GQRKYGGPPPDSVYSGQQPSVGTEIFVG 167

  Fly   161 NLPINTKRVQLVKLFQPYGLVQSIRLRTAGGKQLFKHKQRKVAGSLN---AYVVLEKPEIAQQAL 222
            .:|.:....:||.||:..|.:..:||           ....:.| ||   |:|.....|.||:|:
Human   168 KIPRDLFEDELVPLFEKAGPIWDLRL-----------MMDPLTG-LNRGYAFVTFCTKEAAQEAV 220

  Fly   223 AL-NGSEFKE-NHLRVTPASMAEKFGQAKDKQPSDKDAKRTIFVGSLKYSATEEQLREIFSSC-- 283
            .| |..|.:. .|:.|..:.                 |...:||||:..|.|:||:.|.||..
Human   221 KLYNNHEIRSGKHIGVCISV-----------------ANNRLFVGSIPKSKTKEQILEEFSKVTE 268

  Fly   284 GEIDYIRCLQDGDKGCKGVAYVCFQKPDAVGLALELNQTLLDDR--------------PINVERY 334
            |..|.|...|..||  |.....||.:.:....|.:..:.|:..:              ||.....
Human   269 GLTDVILYHQPDDK--KKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDP 331

  Fly   335 QV-KKLGAKQVRDAA----------AASAASKTSSKTKAKN------QNSAGAKKRLDKKKGKEN 382
            :| .|:....||:.|          |.|...|.....|.|:      ....||.|.:::..||:
Human   332 EVMAKVKVLFVRNLANTVTEEILEKAFSQFGKLERVKKLKDYAFIHFDERDGAVKAMEEMNGKD- 395

  Fly   383 GSLKKE------GAPTGQKKKSEYRGVKVDGIKKAKKPKKKS 418
              |:.|      ..|..||:|.          :||::...|:
Human   396 --LEGENIEIVFAKPPDQKRKE----------RKAQRQAAKN 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12288	NP_609822.1	RRM1_RBM34	156..237	CDD:409828	24/85 (28%)
		RRM_SF	261..332	CDD:473069	24/86 (28%)
SYNCRIP	NP_006363.4	NURR_hnRNPQ	23..107	CDD:410954	8/40 (20%)
		hnRNP-R-Q	103..615	CDD:273732	86/395 (22%)
		Interaction with APOBEC1	400..561		7/36 (19%)
		8 X 3 AA repeats of R-G-G	448..559
		3 X 4 AA repeats of Y-Y-G-Y	460..488
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	497..623
		Interaction with SMN. /evidence=ECO:0000269|PubMed:11574476	518..549
		Bipartite nuclear localization signal. /evidence=ECO:0000255	564..578