DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tweek and kiaa1109

DIOPT Version :9

Sequence 1:	NP_001286002.1	Gene:	tweek / 35026	FlyBaseID:	FBgn0261671	Length:	5150	Species:	Drosophila melanogaster
Sequence 2:	NP_001072203.1	Gene:	kiaa1109 / 779649	XenbaseID:	XB-GENE-5902543	Length:	765	Species:	Xenopus tropicalis

Alignment Length:	775	Identity:	317/775 - (40%)
Similarity:	474/775 - (61%)	Gaps:	59/775 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 NSTHNV-SLNDM-----NLDARMIWLLASLLTTITWVTYITFYNSRVIGMLITKIANRWFIKGAY 83
            |.|:.| |:.|:     ..|:.::|||.:.:.:..|:.|:|:||||.||:::|.:.||.: |..|
Frog     3 NKTNLVPSITDLEGFLTEHDSNVVWLLVATILSCGWIIYLTYYNSRNIGLILTLVLNRLY-KNGY 66

  Fly    84 FKIGSVALNPLAGKIMFRDFVYITYDYTVRAQDGYFIFRWWRSYVPKDVSEDLSHSDTRLSVQLN 148
            ..|||.:.:.|:||||.|:..||:.|.::|.|||:.|||||:.|.||....| ..::|||.:.:|
Frog    67 IHIGSFSFSVLSGKIMLREIYYISEDMSIRIQDGFIIFRWWKMYNPKQKQHD-PKAETRLYITVN 130

  Fly   149 GYELHIYNRSDLYDTLEKTFGLEPSLLIPTDAASNEERNKLKEHHMNLENARQSQRIQNVK-NSE 212
            .:|.|:|||||:|..|::.|||:.::..|     .:|..|::|.    |..:....:::|| .:|
Frog   131 DFEFHVYNRSDIYGHLQEVFGLDQTIFPP-----KKEDEKVQES----EKEKSQSELESVKFKTE 186

  Fly   213 AMQ-ATTWRDLIPVIKIDVCSGRFVFGNRLTPTTLSISVEEAHCTYSTKPAVCRLDHFMHFVKAK 276
            :.. :::||.||||||:::.:||..|||...|.||.::.::|..||:|||....||.|||.:|.|
Frog   187 SPDPSSSWRSLIPVIKVNISTGRLAFGNHYQPQTLCVNFDDAFLTYTTKPPSSHLDQFMHILKGK 251

  Fly   277 VENAKVLFCPSPKYTGL-IDEPPRYMGEGFVVMMSNQMDLYFYMDEPGVVPEHPVQIVLPNGDVV 340
            :||.:|:..|||:|.|| .|||||.||||||||.||.:|:|:||||||:|||.       :|:.|
Frog   252 LENVRVMLVPSPRYVGLQNDEPPRLMGEGFVVMQSNDVDIYYYMDEPGLVPEE-------SGENV 309

  Fly   341 EPS-----------PPVWGINARCLRGTDFSYGPWADRQRDHLYRYFYPSDWKEAEVTPTPQPGE 394
            |..           ||.||::..|.:||||:|||||||||:.|:::|:|.|::..:|:...|||:
Frog   310 EEEANTEDAKLQDLPPCWGLDIVCGKGTDFNYGPWADRQRECLWKFFFPPDYQVMKVSEVAQPGK 374

  Fly   395 LRSYQSFDVTLCVLNEATIDILFSKEKETNAMHITVGPASYVEMTIPWVTQPDGYTSKIQGQLFH 459
            ||..|:|::.:.::..||||:||:|.:||||:|:.|...||:|:.||.....:||:..|:|||.|
Frog   375 LRQIQAFELRMNIIANATIDLLFTKNRETNAVHVNVWAGSYLEVNIPMTVSENGYSPTIKGQLLH 439

  Fly   460 VEATTSLQYRSLAEFESLEYKVRIHYPTKWNAPQDWSISLSGCKTSAFIVYKHKCFFQDLIEDWA 524
            |:.|||:|||:|.|.|.|.:.:...||..||.||.|...|...|.:...::..|.||.|||:||:
Frog   440 VDTTTSMQYRTLLEAEMLAFHINASYPRVWNMPQTWQCELEVYKATYHFIFAQKNFFTDLIQDWS 504

  Fly   525 NKARPDILSFVPYTCNFSIRLHEFEILMLCNEYNWIDCSSANQENNHLAFCGDVFEMSFALPFDD 589
            :.:.||:.||||||.|..|..|:||::...|::||||||:..|||.:||.||:...:.|||||.|
Frog   505 SDSAPDLFSFVPYTWNLKIMFHQFEMIWAANQHNWIDCSTKQQENIYLAACGETLNIDFALPFTD 569

  Fly   590 FLPKTVTLKFWIHGEGLDLSLYVPEV--SSVRPIVLAIDENARLL------TREGKLIRRPELYS 646
            |:|.|.:.:|.:.|..:||.|::|:.  |....:.|..|.:...:      |.|.:..::  ...
Frog   570 FVPTTCSTRFSLRGGDVDLHLFLPDCHPSKYSLLTLLKDFHPNKISPDTCNTAENQSAQK--TCK 632

  Fly   647 KKWRKICQRSAGWIDCWAVPILALSIQYVYHPVPPLGPDPQADITTPEKEEILLSPMRIPKVRKS 711
            .|||.:.|...||::||.||.:.|:|.|.:||:.|...|.|...:..|.||.:||.:| |..|.|
Frog   633 PKWRNVTQAGTGWVECWTVPSMLLNIDYTWHPIYPQKADEQLKQSLSEIEESMLSMLR-PSRRTS 696

  Fly   712 --PVSSWQQPPEQYSK--FDPGTLAADHVTVELEIG-SSVLMAYGNVLRNFISLK-ENIF 765
              .:||    |..||:  .||..|..|.:.||||:. .|.::.||.:|..|:::| .||:
Frog   697 ERAISS----PTTYSRTAVDPSELPPDKLHVELELSPDSQIIFYGPLLMAFLAIKVTNIY 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
tweek	NP_001286002.1	FSA_C	4415..5113	CDD:287455
kiaa1109	NP_001072203.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1617	1.000	Domainoid score	I5
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2353	1.000	Inparanoid score	I35
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D49261at33208
OrthoFinder	1	1.000	-	-		FOG0004645
OrthoInspector	1	1.000	-	-		oto103812
Panther	1	1.100	-	-	LDO	PTHR31640
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5244
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160