Protein Alignment tweek and LOC101734304

DIOPT Version :10

• Sequence 1: NP_001286002.1
• Gene: tweek / 35026
• FlyBaseID: FBgn0261671
• Length: 5150
• Species: Drosophila melanogaster
• Sequence 2: XP_031758459.1
• Gene: LOC101734304 / 101734304
• XenbaseID: XB-GENE-29087667
• Length: 810
• Species: Xenopus tropicalis
• Alignment Length: 1251
• Identity: 304/1251 - (24%)
• Similarity: 419/1251 - (33%)
• Gaps: 647/1251 - (51%)

  Fly  4026 GSPTPSRRQRDKSKLRYNANALLADLTIFHIPGLDVKLHYQSKTL-------------------A 4071
            |...||..|...|.|         :.|:|:|||:||||||.||||                   .
 Frog    75 GKKVPSSLQTKPSDL---------ETTVFYIPGVDVKLHYNSKTLKTESPNASRGSSLPRTLSKE 130

  Fly  4072 EQLTG-------------------------DQLPTGRRMGS---KRATLCAWMTLQSIPEETIIS 4108
            .:|.|                         ..:|:.:..||   |.|.|.||:.|||:|||.:||
 Frog   131 SKLYGMKDTATSPLPSSVHSKTNTLLPPQSPPMPSAKGKGSSGVKTAKLYAWVALQSLPEEMVIS 195

  Fly  4109 PHILEFLEQTLEPIPARQSSSVPPTPSHNTGVN-------------------LDILPANYVTYAS 4154
            |::|:|||:.||.||      :.|...:...|:                   ..::.::...|:|
 Frog   196 PNLLDFLEKALETIP------ITPVERNYAAVSSQDEDIGQFDLQDPLEESTTSLVSSSTSPYSS 254

  Fly  4155 FPVDVIVYFHMQPSTFRFSCLPVSRVECMLQLPSLDIVFSSKRSSEEE------------NSAQP 4207
            |||||:||..:|||..||||||||||||||:|||||:||||.||..|.            |.:.|
 Frog   255 FPVDVVVYVRVQPSQIRFSCLPVSRVECMLKLPSLDLVFSSNRSELETLGPSHPSDSSIGNLSMP 319

  Fly  4208 GGH-----------TQPDQQLPTG-------------------GLSVTGCLADFNVFIFHPYG-G 4241
            .|.           |.|....|.|                   |||.|.|::||::::||||| |
 Frog   320 SGSKPNLNKSGMPGTSPGLGSPLGRTRHSSSQSDLTSSSSNSSGLSFTACMSDFSLYVFHPYGAG 384

  Fly  4242 KKTSK------------ETQFSPLSDSERKDSLSINVEFVKFHITRCRK----VYIEPLPSSKRS 4290
            |:.|.            :....|.|.:.||||||||:||||..::|.|:    .:.|.:.::|..
 Frog   385 KQKSAVSGLTPGPSGLGQVDEEPTSVTGRKDSLSINLEFVKVSLSRMRRSGGASFFESVSANKTP 449

  Fly  4291 LDQSRAVIRFSTIVDIGSASFKYDMRRLTEILAFPKAWYRRRIVRRLFLGDLSVQQQQQQQQGNG 4355
            ......:|..|.:.||||||||||||||:||||||:|||||.|.|.|||||.::
 Frog   450 SKMDTTLINISAVCDIGSASFKYDMRRLSEILAFPRAWYRRSIARHLFLGDQTI----------- 503

  Fly  4356 AETPTGCPPATPTPNEDASRAKDNMRLDFDGQPSQQQQQLGHFGAVRHLKNLGKSSSAESSGTPP 4420
                                                              ||           |.
 Frog   504 --------------------------------------------------NL-----------PG 507

  Fly  4421 SEKNQITAWETLVIFAVNFTKLNVQMNIGNVCGNVVWLTKDFQSDGRLSIGSTGYKNMYAGIYLG 4485
            |.::.....:||                            ||
 Frog   508 SSEHSTYIVQTL----------------------------DF----------------------- 521

  Fly  4486 GSALDAKGGIVGGSFEVNKINKRFHIKEEAGMEPYHTMGLSFMALELRLDYMGTSVLMTRISSFS 4550
                                                              ::|.:.::|:
 Frog   522 --------------------------------------------------HLGHNTMVTK----- 531

  Fly  4551 AAMKDEWRTASQAAATPAHGKDQPRALIFIHGDLTWDQLQIMISKSTTADLLKMYFKLEEFFTQQ 4615
                            |....:.|.|               .|:|.|
 Frog   532 ----------------PCGALESPMA---------------TITKIT------------------ 547

  Fly  4616 FKSSKRVFSNLEPRLQDRTASIKRRQQHKKKPANGELVAPPQIHGMIGENTDARHHRHWQKPLAQ 4680
                                    |::|:..|
 Frog   548 ------------------------RRRHENPP--------------------------------- 555

  Fly  4681 AVGLVVPSLVTRLPRHGNVLGGTVELRGQNISLACFHGINFKSKSWALFSLRSPSINFATEARQS 4745
                                                ||:
 Frog   556 ------------------------------------HGV-------------------------- 558

  Fly  4746 EDEVLVTQTLTSSLGQTTEVQQQQNHSMAIVSRITRNIIFPPQFKTLNEWFHY--AFANSEIDAV 4808
                                                        .::.|||:|  |..|.|::.:
 Frog   559 --------------------------------------------ASVQEWFNYVTAMRNEELNLL 579

  Fly  4809 DRFPMLECEREIASNSIERTRASGSSSAAK----AQEHNHNREVIFALPSLQLHFKTEHKQGPTT 4869
                     |.:.:|:.|.:.|..:||...    ...:||..|.|||||.:||.||:.|.|.|..
 Frog   580 ---------RNVDANNAESSTAVKNSSLLSGFRGGSSYNHETETIFALPRMQLDFKSIHVQEPQE 635

  Fly  4870 PEPSVLCSIAENKPEVLCSFITEFDDHIFVTVDADAFFFLHDLITSYVTEKEKVIGAQSARAASP 4934
            |   ||..  ::||:|.||.:|||.|||.||:||:...||||::::|:.|||||  ....|..:.
 Frog   636 P---VLQD--DSKPKVECSVLTEFTDHICVTMDAELIIFLHDMVSAYLKEKEKV--KFPPRVFTT 693

  Fly  4935 NLSQKANLKPYL-TDEILKEKKGASNTNLTAQGKQTSGSKNSLDPLQGSHTSLANAAANMSGAAT 4998
            ...||:   |.: .:|...||:...|||.|
 Frog   694 RPGQKS---PVIQINESSSEKEKEENTNYT----------------------------------- 720

  Fly  4999 TNTTTTTTATTLSPGAAAGGPSTSATNDSVDGKQQQQEGSPPTFDLESFVRDWRHFECQTWHLEP 5063
                                                            :| |||.|.|.||||||
 Frog   721 ------------------------------------------------YV-DWREFMCNTWHLEP 736

  Fly  5064 TVRLLSWAGKSIEPYGVDYILNKLGFSHARTTIPKWLQRGFMDPLDKVQALMMLQLLLMVRENKV 5128
            |:||:||.|:.|:|.||||||.||||.|||||||||||||.|||||||.::::.:|...:::.|.
 Frog   737 TLRLISWTGRKIDPVGVDYILQKLGFHHARTTIPKWLQRGVMDPLDKVLSVLIKKLGSALQDEKE 801

  Fly  5129 ERDSGASGSGKQQQQN 5144
            ::       ||.::::
 Frog   802 KK-------GKDKEEH 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tweek	NP_001286002.1	Kiaa1109_N	61..1065	CDD:466562
		FSA_C	4415..5113	CDD:463105	136/704 (19%)
LOC101734304	XP_031758459.1	A_deamin	3..>42	CDD:470647
		FSA_C	<511..792	CDD:463105	134/701 (19%)