DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6012 and Hsd17b12

DIOPT Version :9

Sequence 1:	NP_609817.1	Gene:	CG6012 / 35022	FlyBaseID:	FBgn0032615	Length:	308	Species:	Drosophila melanogaster
Sequence 2:	NP_114455.2	Gene:	Hsd17b12 / 84013	RGDID:	708367	Length:	312	Species:	Rattus norvegicus

Alignment Length:	287	Identity:	94/287 - (32%)
Similarity:	160/287 - (55%)	Gaps:	21/287 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SAFLTFVGVYALSSYLYEQLRTPYKLIKIRYFS----GTRPTLKERFGDWAAVTGASDGIGKEYA 66
            :.||.:||.   |:..|..||..|.|  .|.|.    |.:..:..|.|:||.|||.:|||||.||
  Rat     8 AGFLYWVGA---STIAYLTLRASYSL--FRAFQVWCVGNQAFVGPRLGEWAVVTGGTDGIGKSYA 67

  Fly    67 KELARQNINVVLIARTEEKLQAVAKEIADCGAGVQTKIVIADFTKGSQVYEHIEKETANIPISIL 131
            :|||::.:.:|||:|:::||:.|:..|.: ...|:|:.:..||:. ..:|:.|:...:.:.|.:|
  Rat    68 EELAKRGMKIVLISRSQDKLKEVSNNIKE-KFNVETRTIAVDFSL-DDIYDKIKTGLSGLEIGVL 130

  Fly   132 VNNVGIA--TPKSLLKYNQEET--QNIIDTNVVAVSQLSRIFFQRMKASKLKGAIVNVGSGTELQ 192
            |||||::  .|:..|:....:.  :.:|:.||:::.:::|:....| ..:.||.|:|:.|.:.:.
  Rat   131 VNNVGMSYEYPEYFLEIPDLDNTIKKLININVLSICKVTRLVLPGM-VERSKGVILNISSASGML 194

  Fly   193 PLPNGAYYAASKAYTRSLTLALYHEAKPYGIHVQMLSPNFVVTKINSYSRQIMKGGLLIPSASAY 257
            |:|....|:|:||:....:..|:.|.|..||.||.:.|.||.||:    .:|.|..|..|||..:
  Rat   195 PVPLLTVYSATKAFVDFFSQCLHEEYKSKGIFVQSVLPFFVATKL----AKIRKPTLDKPSAETF 255

  Fly   258 AKSAVNQLRDEVDETPGYLWHHVQNAV 284
            .|||:..:..:. .|.||:.|.:..::
  Rat   256 VKSAIKTVGLQT-RTTGYVIHAIMGSI 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6012	NP_609817.1	17beta-HSD1_like_SDR_c	49..296	CDD:187614	80/240 (33%)
CG6012	NP_609817.1	adh_short	51..243	CDD:278532	66/195 (34%)
Hsd17b12	NP_114455.2	17beta-HSD1_like_SDR_c	50..289	CDD:187614	80/240 (33%)
Hsd17b12	NP_114455.2	Di-lysine motif. /evidence=ECO:0000250	308..312
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53762
OrthoDB	1	1.010	-	-		D584062at33208
OrthoFinder	1	1.000	-	-		FOG0000465
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.930