DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6012 and Hsd17b12

DIOPT Version :9

Sequence 1:	NP_609817.1	Gene:	CG6012 / 35022	FlyBaseID:	FBgn0032615	Length:	308	Species:	Drosophila melanogaster
Sequence 2:	NP_062631.1	Gene:	Hsd17b12 / 56348	MGIID:	1926967	Length:	312	Species:	Mus musculus

Alignment Length:	294	Identity:	97/294 - (32%)
Similarity:	160/294 - (54%)	Gaps:	23/294 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFCA--LSAFLTFVGVYALSSYLYEQLRTPYKLIKIRYFS----GTRPTLKERFGDWAAVTGASD 59
            |.||  .:.||.:||.   |:..|..||..|.|  .|.|.    |....:..|.|:||.|||.:|
Mouse     1 MECAPPAAGFLYWVGA---STIAYLALRASYSL--FRAFQVWCVGNEALVGPRLGEWAVVTGGTD 60

  Fly    60 GIGKEYAKELARQNINVVLIARTEEKLQAVAKEIADCGAGVQTKIVIADFTKGSQVYEHIEKETA 124
            ||||.||:|||::.:.:|||:|:::||..|:..|.: ...|:|:.:..||:. ..:|:.|:...:
Mouse    61 GIGKAYAEELAKRGMKIVLISRSQDKLNQVSNNIKE-KFNVETRTIAVDFSL-DDIYDKIKTGLS 123

  Fly   125 NIPISILVNNVGIA--TPKSLLKYNQEET--QNIIDTNVVAVSQLSRIFFQRMKASKLKGAIVNV 185
            .:.|.:||||||::  .|:..|:....:.  :.:|:.||::|.:::|:....| ..:.||.|:|:
Mouse   124 GLEIGVLVNNVGMSYEYPEYFLEIPDLDNTIKKLININVLSVCKVTRLVLPGM-VERSKGVILNI 187

  Fly   186 GSGTELQPLPNGAYYAASKAYTRSLTLALYHEAKPYGIHVQMLSPNFVVTKINSYSRQIMKGGLL 250
            .|.:.:.|:|....|:|:||:....:..|:.|.|..||.||.:.|..|.||:    .:|.|..|.
Mouse   188 SSASGMLPVPLLTIYSATKAFVDFFSQCLHEEYKSKGIFVQSVMPYLVATKL----AKIQKPTLD 248

  Fly   251 IPSASAYAKSAVNQLRDEVDETPGYLWHHVQNAV 284
            .|||..:.|||:..:..:. .|.||:.|.:..::
Mouse   249 KPSAETFVKSAIKTVGLQT-RTTGYVIHSLMGSI 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6012	NP_609817.1	17beta-HSD1_like_SDR_c	49..296	CDD:187614	80/240 (33%)
CG6012	NP_609817.1	adh_short	51..243	CDD:278532	66/195 (34%)
Hsd17b12	NP_062631.1	NADB_Rossmann	<4..>83	CDD:304358	34/83 (41%)
		DltE	46..305	CDD:223377	81/244 (33%)
		17beta-HSD1_like_SDR_c	50..288	CDD:187614	80/240 (33%)
		Di-lysine motif. /evidence=ECO:0000250	308..312
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0300
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53762
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000465
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820