Protein Alignment CG6012 and HSD17B12

DIOPT Version :10

• Sequence 1: NP_609817.1
• Gene: CG6012 / 35022
• FlyBaseID: FBgn0032615
• Length: 308
• Species: Drosophila melanogaster
• Sequence 2: NP_057226.1
• Gene: HSD17B12 / 51144
• HGNCID: 18646
• Length: 312
• Species: Homo sapiens
• Alignment Length: 296
• Identity: 99/296 - (33%)
• Similarity: 161/296 - (54%)
• Gaps: 27/296 - (9%)

  Fly     1 MFCALSA--FLTFVGVYALSSYLYEQLRTPYKLI-KIRYF-----SGTRPTLKERFGDWAAVTGA 57
            |..||.|  ||.:||.   .:..|..||..|.|. .:|.:     :|..|.|    |:||.|||:
Human     1 MESALPAAGFLYWVGA---GTVAYLALRISYSLFTALRVWGVGNEAGVGPGL----GEWAVVTGS 58

  Fly    58 SDGIGKEYAKELARQNINVVLIARTEEKLQAVAKEIADCGAGVQTKIVIADFTKGSQVYEHIEKE 122
            :|||||.||:|||:..:.||||:|:::||..|:.||.: ...|:|:.:..||. ...:|:.|:..
Human    59 TDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKE-KFKVETRTIAVDFA-SEDIYDKIKTG 121

  Fly   123 TANIPISILVNNVGIA--TPKSLLKYNQEET--QNIIDTNVVAVSQLSRIFFQRMKASKLKGAIV 183
            .|.:.|.|||||||::  .|:..|.....:.  :.:|:.|:::|.:::::....| ..:.||||:
Human   122 LAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGM-VERSKGAIL 185

  Fly   184 NVGSGTELQPLPNGAYYAASKAYTRSLTLALYHEAKPYGIHVQMLSPNFVVTKINSYSRQIMKGG 248
            |:.||:.:.|:|....|:|:|.:....:..|:.|.:..|:.||.:.|.||.||:    .:|.|..
Human   186 NISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSVLPYFVATKL----AKIRKPT 246

  Fly   249 LLIPSASAYAKSAVNQLRDEVDETPGYLWHHVQNAV 284
            |..||...:.|||:..:..: ..|.|||.|.:..::
Human   247 LDKPSPETFVKSAIKTVGLQ-SRTNGYLIHALMGSI 281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6012	NP_609817.1	17beta-HSD1_like_SDR_c	49..296	CDD:187614	82/240 (34%)
HSD17B12	NP_057226.1	17beta-HSD1_like_SDR_c	50..289	CDD:187614	82/240 (34%)
		Di-lysine motif	308..312