DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6012 and Hsdl1

DIOPT Version :9

Sequence 1:	NP_609817.1	Gene:	CG6012 / 35022	FlyBaseID:	FBgn0032615	Length:	308	Species:	Drosophila melanogaster
Sequence 2:	NP_001020067.1	Gene:	Hsdl1 / 361418	RGDID:	1308433	Length:	330	Species:	Rattus norvegicus

Alignment Length:	288	Identity:	106/288 - (36%)
Similarity:	159/288 - (55%)	Gaps:	18/288 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CALSAFLTFVGVYALSSYLYEQLRTPYKLIKIRYFS--GTRPTLKERFGDWAAVTGASDGIGKEY 65
            |.:.| |..||.:..:......:...|.|:::.:..  |:||.|.:::|.||.::||:|||||.|
  Rat    20 CYVEA-LALVGAWYTARKSIPVICDFYSLVRLHFIPRLGSRPDLIKQYGRWAVISGATDGIGKAY 83

  Fly    66 AKELARQNINVVLIARTEEKLQAVAKEIADCGAGVQTKIVIADFTKGSQVYEHIEKETANIPISI 130
            |:|||...:|::||::.|||||||||.|||. ..|:|.:::|||::|.::|..|.:...:..|.|
  Rat    84 AEELASHGLNIILISQEEEKLQAVAKHIADT-YRVETLVLVADFSRGREIYAPIREALRDRDIGI 147

  Fly   131 LVNNVGIATPKSLLKYNQEETQ-------NIIDTNVVAVSQLSRIFFQRMKASKLKGAIVNVGSG 188
            |||:||...|     |.|..:|       :|::.|:.|.|.:..|....|...| |||||.|.||
  Rat   148 LVNDVGAFYP-----YPQYFSQVPEDTIWDIVNVNIAAASLMVHIVLPGMVERK-KGAIVTVSSG 206

  Fly   189 TELQPLPNGAYYAASKAYTRSLTLALYHEAKPYGIHVQMLSPNFVVTKINSYSRQIMKGGLLIPS 253
            :..:|.|..|.::|||||....:.||.:|....||.||.|.|.:|.:.:.:....:.:...|.||
  Rat   207 SCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLIPFYVTSSVTAPGSFLRRCPWLAPS 271

  Fly   254 ASAYAKSAVNQLRDEVDETPGYLWHHVQ 281
            ...||:.||:.|... ..|.||..|.:|
  Rat   272 PRVYAQHAVSTLGIS-KRTTGYWSHSIQ 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6012	NP_609817.1	17beta-HSD1_like_SDR_c	49..296	CDD:187614	95/240 (40%)
CG6012	NP_609817.1	adh_short	51..243	CDD:278532	81/198 (41%)
Hsdl1	NP_001020067.1	Required for mitochondria translocation. /evidence=ECO:0000250	2..82		20/62 (32%)
Hsdl1	NP_001020067.1	17beta-HSD1_like_SDR_c	67..309	CDD:187614	95/240 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335273
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0300
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53762
OrthoDB	1	1.010	-	-		D584062at33208
OrthoFinder	1	1.000	-	-		FOG0000465
OrthoInspector	1	1.000	-	-		otm45003
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3003
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.720