Protein Alignment Nepl9 and ECE2

DIOPT Version :10

• Sequence 1: NP_609815.1
• Gene: Nepl9 / 35020
• FlyBaseID: FBgn0032613
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: NP_001093590.1
• Gene: ECE2 / 9718
• HGNCID: 13275
• Length: 811
• Species: Homo sapiens
• Alignment Length: 744
• Identity: 146/744 - (19%)
• Similarity: 246/744 - (33%)
• Gaps: 245/744 - (32%)

  Fly    59 DSMD----PCDDFYAHACGNFDQTKEENSDDFLPPYLYNKQDRMNFFTAEVGNFETIPGRLI--- 116
            :|:|    ||:|||..:||.:.:...      ||    :.:.|.|.|.:.....:.|...|:
Human   154 ESLDRGVSPCEDFYQFSCGGWIRRNP------LP----DGRSRWNTFNSLWDQNQAILKHLLENT 208

  Fly   117 ------------SQLYTECR--KREERNVFTPTR----------LTSHWERMLDEIPFLARHKEV 157
                        .:.|..|.  :|.|.....|.|          :|..|    |:..|:...|.|
Human   209 TFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGPW----DQDNFMEVLKAV 269

  Fly   158 LSSW---PFLKHQWERRRLYGQLNWIVLSAQLAAHGLPTLLHIYFALDTIYVSPMEELPCPSIAD 219
            ..::   ||.                                      |:|:|          ||
Human   270 AGTYRATPFF--------------------------------------TVYIS----------AD 286

  Fly   220 FQSSLSDVLE---------GRHHQVSRIIS-----------HEMRVLC--------REMRGELPL 256
            .:||.|:|::         .|.:.::|..:           .|:.:|.        .:|:..|.|
Human   287 SKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLEL 351

  Fly   257 VRSLSQNTRTNTSRPGEEQLL----LDE-----NTMDYFQQYFAALNFSEERLVGARKFPLDV-- 310
            ...|:..|.....|..||::.    :.|     .:||:.:    .|:|....|..:...|:.|
Human   352 EIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLE----FLSFLLSPLELSDSEPVVVYG 412

  Fly   311 -EKITQAWEVLRHTETRIVYNYVMWQAREQLRYPDCYRVSEEFERLLHAEY---------WQWHV 365
             :.:.|..|::..||..|:.||::|...::.......|.....|:||...|         ||..:
Human   413 MDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCI 477

  Fly   366 LRRHLSREVALASYQLHTT---RFQKLRRSKLSR-----RDWYGHL-WPASVEKKELQVAR---- 417
            .....:...||.|..:..|   :.:::....:|.     .:..|.| |   :::|..|.|:
Human   478 SNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQLVW---MDEKTRQAAKEKAD 539

  Fly   418 ---ILQNHAENYLNITELNENYEGLKLEKNSFYANLLIL-------RRAQLRHSFVSPYVDE--- 469
               .:....:..|...||::.|:|.::.::||:.|:|.|       ...|||.   .|..|:
Human   540 AIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRK---PPSRDQWSM 601

  Fly   470 --EDVNQPAYFL--RHFLHFVLLSLHRPTY----------------------HYYATHGLELWRE 508
              :.||  ||:|  ::.:.|....|..|.|                      |.:...|.|..:|
Human   602 TPQTVN--AYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKE 664

  Fly   509 SRL-------LLDTDGHYTAMDCLERQSFQHYDAKLAPIYRPLGSHEIAEIFQFYRSFQYSLTDY 566
            ..|       .|....::||  |:|.| :..|.....   |..|...:.|........:.:...|
Human   665 GNLRPWWQNESLAAFRNHTA--CMEEQ-YNQYQVNGE---RLNGRQTLGENIADNGGLKAAYNAY 723

  Fly   567 HFWLQGERFAFAETFVLDYFGLNPHRVLFYAVAQQLCNRQTEIFAAQLNRGYMNLP--------- 622
            ..||:    ...|...|...||..|::.|...||..|:.:|   ....:.|.:..|
Human   724 KAWLR----KHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRT---PESSHEGLVTDPHSPARFRVL 781

  Fly   623 -------EFQEAFKCGAEKAMNPPSRCMI 644
                   :|...|.|.....|||...|.:
Human   782 GTLSNSRDFLRHFGCPVGSPMNPGQLCEV 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl9	NP_609815.1	GluZincin	62..642	CDD:472708	144/737 (20%)
ECE2	NP_001093590.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..64
		M13	160..809	CDD:341056	143/735 (19%)