DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl9 and Ece1

DIOPT Version :9

Sequence 1:	NP_609815.1	Gene:	Nepl9 / 35020	FlyBaseID:	FBgn0032613	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_006239337.1	Gene:	Ece1 / 94204	RGDID:	620293	Length:	769	Species:	Rattus norvegicus

Alignment Length:	734	Identity:	130/734 - (17%)
Similarity:	242/734 - (32%)	Gaps:	231/734 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 SMDPCDDFYAHACGNFDQTKE---------------ENSDDFLPPYLYNKQDRMNFFTAEVGNFE 109
            ::|||.||:::|||.:.:...               |::...:...|.|.       ||.....|
  Rat   117 TVDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENS-------TASASEAE 174

  Fly   110 TIPGRLISQLY-----TECRKREER--------------NVFTPTR----------LTSHWERML 145
            .     .:|:|     .|.|..|.|              |:..|..          :|:|:...
  Rat   175 K-----KAQVYYRACMNETRIEELRAKPLMELIEKLGGWNITGPWAKDNFQDTLQVVTAHYRTS- 233

  Fly   146 DEIPFLARHKEV------------------LSSWPFLKHQWERRR-LYGQLNWIVLSAQLAAHGL 191
               ||.:.:...                  |.|..:..::.|..: |.|.||::|...:|...|
  Rat   234 ---PFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGG- 294

  Fly   192 PTLLHIYFALDTIYVSPMEELPCPSIADFQSSLSDVL---EGRHHQVSRIISHEMRVLCREMRGE 253
                      |...:.|..:    .|.||:::|:::.   |.|..:  .:|.|  :|...|::..
  Rat   295 ----------DEDSIRPQMQ----QILDFETALANITIPQEKRRDE--ELIYH--KVTAAELQTL 341

  Fly   254 LPLVRSLSQNTRTNTSRPGEEQLLLDENTMDYFQQYF--AALNFSEERLVGARKFPLDVEKITQA 316
            .|.:                       |.:.:....|  ..:|.||..:|      .|.|.:.|.
  Rat   342 APAI-----------------------NWLPFLNAIFYPVEINESEPIVV------YDKEYLRQV 377

  Fly   317 WEVLRHTETRIVYNYVMWQ-AREQLRYPDCYRVSEEFERLLHAEY---------WQWHVLRRHLS 371
            ..::..|:..::.||:||. .|:...:.| .|..:..|:.:...|         |::.|.....:
  Rat   378 STLINSTDKCLLNNYMMWNLVRKTSSFLD-QRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENN 441

  Fly   372 REVALASYQLHTT--------------RFQKLRRSKLSRRDWYGHLWPASVEKKELQVARILQNH 422
            ...||....:..|              ..:|.....||...|.......|.::|...:..:: .:
  Rat   442 LGFALGPMFVKATFAEDSKNIASEIILEIKKAFEESLSTLKWMDEDTRRSAKEKADAIYNMI-GY 505

  Fly   423 AENYLNITELNENYEGLKLEKNSFYANLL------------ILRRAQLR----------HSFVSP 465
            ....::..||::.:.......:.::.|.:            .||:|..|          :::.||
  Rat   506 PNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSP 570

  Fly   466 YVDE----EDVNQPAYFLR---HFLHFVLLSL---HRPTYHYYATHGLEL---------WRESRL 511
            ..:|    ..:.|..::.|   :.|:|..:.:   |..| |.:...|.|.         |:.|
  Rat   571 TKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELT-HAFDDQGREYDKDGNLRPWWKNS-- 632

  Fly   512 LLDTDGHYTAMDCLERQSFQHYDAKLAPIYRPLGSHEIAEIFQFYRSFQYSLTDYHFWLQGERFA 576
              ..:......:|:.:| :.:|.....|:.   |.|.:.|........:.:...|..|::...
  Rat   633 --SVEAFKQQTECMVQQ-YNNYSVNGEPVN---GRHTLGENIADNGGLKAAYRAYQNWVKKNG-- 689

  Fly   577 FAETFVLDYFGLNPHRVLFYAVAQQLCNRQTEIFAAQLNRGYM----------------NLPEFQ 625
             ||. :|...||..:::.|...||..|:.:|   ....:.|.:                |..||.
  Rat   690 -AEQ-ILPTLGLTSNQLFFLGFAQVWCSVRT---PESSHEGLITDPHSPSRFRVIGSLSNSKEFS 749

  Fly   626 EAFKCGAEKAMNPPSRCMI 644
            |.|:|.....|||..:|.:
  Rat   750 EHFRCPLGSPMNPRHKCEV 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl9	NP_609815.1	GluZincin	62..>84	CDD:301352	9/36 (25%)
Nepl9	NP_609815.1	GluZincin	<579..642	CDD:301352	19/78 (24%)
Ece1	XP_006239337.1	PepO	105..769	CDD:226118	130/734 (18%)
Ece1	XP_006239337.1	M13	118..767	CDD:189000	129/730 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000