DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl9 and PHEX

DIOPT Version :9

Sequence 1:	NP_609815.1	Gene:	Nepl9 / 35020	FlyBaseID:	FBgn0032613	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_000435.3	Gene:	PHEX / 5251	HGNCID:	8918	Length:	749	Species:	Homo sapiens

Alignment Length:	752	Identity:	136/752 - (18%)
Similarity:	240/752 - (31%)	Gaps:	254/752 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 NDSMDPCDDFYAHACGNFDQTKEENSDDFLP-----PYLYNKQDRMNFFTAEVGNFETIPGRLIS 117
            |.|:||||:|:..||..:........|  :|     |:|.:..|.         ..:.:..:.||
Human    71 NLSVDPCDNFFRFACDGWISNNPIPED--MPSYGVYPWLRHNVDL---------KLKELLEKSIS 124

  Fly   118 Q------------LYTECRKREERNVFTPTRLTSHWERMLDEIPFL--ARHKEVLSSWPFLKHQ- 167
            :            ||:.|  ..|:.:           ...|..|.|  .||...  .||.|:..
Human   125 RRRDTEAIQKAKILYSSC--MNEKAI-----------EKADAKPLLHILRHSPF--RWPVLESNI 174

  Fly   168 -----WERR---------------------RLYG------------QLNWIVLSAQLAAHGLPTL 194
                 |..|                     |||.            :|:...||..:....|...
Human   175 GPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNS 239

  Fly   195 LH-------IY-FALDTIYV----SPMEELPCPSIADFQSSLSDVLEGRHHQVSRIISHEMRVLC 247
            ..       :| |.:||..:    |...|....|:...:..:::::....::.|..:.::|.:
Human   240 TEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNI-- 302

  Fly   248 REMRGELPLVRSLSQNTRTNTSR--PGEEQLLLDENTMDYFQQYFAALNFSEERLVGARKFPLDV 310
            .|:...:|....|....:...:|  |..:.:...||.:....|||..|    .|::|:.:
Human   303 SELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDL----FRILGSER----- 358

  Fly   311 EKITQAWEVLRHTETRIVYNYVMWQ----------AREQLRYPDCYRVSEEFERLLHAEYWQW-- 363
                          .:.:.||::|:          .|.|.|:.:..||.:....||.    ||
Human   359 --------------KKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLP----QWDK 405

  Fly   364 --HVLRRHLSREVALASYQLHTTRFQKLRRSKL----------------SRRDWYGHLWPASVEK 410
              :.:...|...|......::   ||:.::..:                ...:|    ..|..::
Human   406 CVNFIESALPYVVGKMFVDVY---FQEDKKEMMEELVEGVRWAFIDMLEKENEW----MDAGTKR 463

  Fly   411 KELQVARIL---QNHAENYLNITELNENYEGLKLEKNSFYANLLILRRAQLRHSF---------V 463
            |..:.||.:   ..:.|..:|.|.:||:.:.:|..:..::.|:|..|:...:..|         .
Human   464 KAKEKARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADYFGNVLQTRKYLAQSDFFWLRKAVPKT 528

  Fly   464 SPYVDEEDVNQPAYFLRHFLHFVLLSLHRPTY-------------------HYYATHG------- 502
            ..:.:...||.......:.:.|....|.:|.:                   |.: |||
Human   529 EWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEF-THGFDNNGRK 592

  Fly   503 ------LELW----RESRLLLDTDGHYTAMDCLERQSFQHYDAKLAPI----YRPLGSH-----E 548
                  |:.|    .|.:....|       .|:..| :.:|..|.|.:    .|.||.:     .
Human   593 YDKNGNLDPWWSTESEEKFKEKT-------KCMINQ-YSNYYWKKAGLNVKGKRTLGENIADNGG 649

  Fly   549 IAEIFQFYRSFQYSLTDYHFWLQGERFAFAETFVLDYFGLNPHRVLFYAVAQQLCN--------R 605
            :.|.|:.||.          |:...|....|. :|.......:::.|.:.|...||        .
Human   650 LREAFRAYRK----------WINDRRQGLEEP-LLPGITFTNNQLFFLSYAHVRCNSYRPEAARE 703

  Fly   606 QTEIFA-----AQLNRGYMNLPEFQEAFKCGAEKAMN 637
            |.:|.|     .::|....|..|||:||.|.....||
Human   704 QVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMN 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl9	NP_609815.1	GluZincin	62..>84	CDD:301352	7/21 (33%)
Nepl9	NP_609815.1	GluZincin	<579..642	CDD:301352	19/72 (26%)
PHEX	NP_000435.3	M13	74..747	CDD:189000	134/749 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147245
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840