DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl9 and MME

DIOPT Version :9

Sequence 1:	NP_609815.1	Gene:	Nepl9 / 35020	FlyBaseID:	FBgn0032613	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_000893.2	Gene:	MME / 4311	HGNCID:	7154	Length:	750	Species:	Homo sapiens

Alignment Length:	736	Identity:	138/736 - (18%)
Similarity:	256/736 - (34%)	Gaps:	197/736 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 QLVKIKNDSMDPCDDFYAHACGNFDQTKEENSDDFLPPYLYNKQDRMNFFTAEVGNFETIPGRLI 116
            :|::..:.:.:||.||:.:|||.                 :.|::.:...::..|||:.:...|.
Human    68 RLIQNMDATTEPCTDFFKYACGG-----------------WLKRNVIPETSSRYGNFDILRDELE 115

  Fly   117 SQLYTECRKREERNVFTPTRLTSHWERMLDEIPFLARHKEVL-------SSWPFLKHQWERRRLY 174
            ..|....::.:..::....:..:.:...::|....:|..|.|       ..||.....||::  |
Human   116 VVLKDVLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQK--Y 178

  Fly   175 GQLNWIV--LSAQL-AAHGLPTLLHIYFALD-------TIYV-SPMEELP--------------C 214
            | .:|..  ..||| :.:|...|::::...|       .|:: .|...||              |
Human   179 G-ASWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEAC 242

  Fly   215 PSIADFQSSLSDVLEGRHHQVSRIISHEMRV------LCREMRGELPLVRSLSQNTRTNTSRPGE 273
            .:..||..|           |:|:|..|.|:      |..||...:.|.:.::..|.....| .:
Human   243 TAYVDFMIS-----------VARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDR-ND 295

  Fly   274 EQLLLDENTMDYFQQYFAA---------LNFSEERLVGARKFPL----DV-----EKITQAWEVL 320
            ..||.::.|:...|..|:.         |||:.| ::......:    ||     |.:|:...:|
Human   296 PMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNE-IMSTVNISITNEEDVVVYAPEYLTKLKPIL 359

  Fly   321 RHTETRIVYNYVMWQAREQL--RYPDCYRVSEE-FERLLHAEYWQWHVLRR-------------- 368
            .....|.:.|.:.|:....|  .....|:.|.. |.:.|:....:....||
Human   360 TKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVG 424

  Fly   369 HLSREVALASYQLHTTR--FQKLRRSKLSRRD---WYGHLWPASVEKKELQVARILQNHAENYLN 428
            .|..|.|.|....|...  ..::|...:...|   |.........|:|.|.:...:....:...|
Human   425 RLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSN 489

  Fly   429 ITELNENYEGLKLEKNSFYANLL----ILRRAQLRHSFVSPYVDEED-------VN--------- 473
            ..:||..|..|..:::.::.|::    ..:..||:.  :...||:::       ||
Human   490 DNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKK--LREKVDKDEWISGAAVVNAFYSSGRNQ 552

  Fly   474 --------QPAYF---LRHFLHFVLLSLHRPTYHYYATHGLELWRESRLLLDTDGHYTAMDCLER 527
                    ||.:|   ..:.|::..:.:   ...:..|||.:   ::....:.||  ..:|...:
Human   553 IVFPAGILQPPFFSAQQSNSLNYGGIGM---VIGHEITHGFD---DNGRNFNKDG--DLVDWWTQ 609

  Fly   528 QSFQHY-DAKLAPIYR--------PLGSH---------EIAE---IFQFYRSFQYSLTDYHFWLQ 571
            ||..:: :.....:|:        ..|.|         .||:   :.|.||::|..:...
Human   610 QSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKN----- 669

  Fly   572 GERFAFAETFVLDYFGLNPHRVLFYAVAQQLCNRQTEIFAAQLNRGYMNLP-------------E 623
                  .|..:|....||..::.|...||..|......:|....:..::.|             |
Human   670 ------GEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAE 728

  Fly   624 FQEAFKCGAEKAMNPPSRCMI 644
            |.|||.|.....|||..:|.:
Human   729 FSEAFHCRKNSYMNPEKKCRV 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl9	NP_609815.1	GluZincin	62..>84	CDD:301352	7/21 (33%)
Nepl9	NP_609815.1	GluZincin	<579..642	CDD:301352	19/75 (25%)
MME	NP_000893.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:189000	136/722 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910