DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl9 and Nepl13

DIOPT Version :9

Sequence 1:	NP_609815.1	Gene:	Nepl9 / 35020	FlyBaseID:	FBgn0032613	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster

Alignment Length:	822	Identity:	161/822 - (19%)
Similarity:	262/822 - (31%)	Gaps:	307/822 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 EVEMDSEVESGQFFSHLYK---------SNLQQLVKIK---------NDSMDPCDDFYAHACGNF 75
            |:::....|:.|  :|:.:         |..:|||:.|         |.|.|||.||:.:|||.:
  Fly    20 EIQLCDVTEARQ--NHMNRMQMSGNFPDSREEQLVRQKIATDVQKYMNLSADPCTDFFEYACGQW 82

  Fly    76 DQ--TKEENSDDF----------------------LPPYLYNKQDRMNFFT-AEVGNFETIPGRL 115
            .:  .::...|:.                      |||     |...|.:: |.:.|.     |.
  Fly    83 GRYHKRQLRPDELSTAQQLMETKISEQLQQLLTQPLPP-----QHHPNGYSGASMTNV-----RK 137

  Fly   116 ISQLYTEC----RKREERNVFTPTRLTSHWERMLDEIPFLARHKEVLSSWPFLKHQW-----ERR 171
            :...|..|    ....||..|....|..:..  |..:|        .|:|.. ..||     |.|
  Fly   138 VRAFYESCVAVEANASERRRFLMKILKDNGG--LRNVP--------NSNWQH-NRQWVQTLGELR 191

  Fly   172 RLYGQLNWIVLSAQLAAHGLPTLL--HIYFALDTIYVSPMEELPCPSIADFQSSLSD-VLEGRHH 233
            |.|| |: |:|..::..: |.|:.  .|||....:.:.|.|.  |.::|...:.:.| |.|....
  Fly   192 RNYG-LD-ILLGLEIDLN-LQTMKGNTIYFGEPKLTIIPAEH--CNALATRGAQVRDEVYELVQQ 251

  Fly   234 QVSR-------------------IISHEMRVLCREMRGEL----------PLVRSLSQNTRTNTS 269
            ||:.                   ||..|.. ||::| ||.          |.:::.....|   |
  Fly   252 QVTENLRDWFGMDTGEAARFAGDIIRFEFE-LCKQM-GEQDIQKPEEEFPPAIQAQIYGAR---S 311

  Fly   270 RPGEEQLLLDENTMDYFQQYFAALNFSEERLVGARKFPLDVEKITQAW----------EVLRHTE 324
            |.|:|:|...:..|        .|......:.....|.:.||.|.::.          |.::|..
  Fly   312 RTGQERLRRQKGGM--------TLTELTSEMGNHLDFKMLVEVILESQYPSQVYLRSPEYVKHVV 368

  Fly   325 TRIVYN-------YVMWQAREQLRYP----------DCYRVS---------EEFER--------- 354
            ..:..|       |:::.|..:|..|          .|.:|:         |.|:|
  Fly   369 RTVKANNRITVGGYILYVALNELNQPPEEAPSQRARQCVQVTQRLFPQVLGEMFQRHVQRDNAKH 433

  Fly   355 --------LLHAEYWQWHV----------LRRHLSR-EVALASYQ---LHTTRFQKLRRSKLSRR 397
                    ::.|...|:||          .|..||: .|:|..||   |...:|||      |..
  Fly   434 DLDAVFNDVIKALEEQFHVEWMDENDRRAARTRLSQYRVSLPDYQSLDLTDLQFQK------SED 492

  Fly   398 DWYGHLWPASVEKKELQVARILQNHAE-NYLNITELNENYEGLKLEKNSFYANLLILRRAQLRHS 461
            .|           :.|::|...::|.: ..|...:..::.:||    ::|.....:..|.|:
  Fly   493 YW-----------RRLEIALKYRSHQQFEALRGNDFGQDADGL----DAFEVRAALSPRQQM--- 539

  Fly   462 FVSPYVDEEDVNQPAYFLRHFLHFVLLS---LHRPTYHYYATHGLEL------------------ 505
                                    ||:.   |..|.|:||....|:.
  Fly   540 ------------------------VLVGWGLLQAPYYNYYYPKSLKYALLGHRLASALVQAFDDE 580

  Fly   506 -----------WRESRLLLDTDGHYTAMDCLERQSFQHYDAKLAPIYRPLG----SHEIAEIFQF 555
                       |.|    :...|:..|.:| :|..:..|      :|...|    :..:.||...
  Fly   581 GWNNHPQATAQWNE----VTMSGYRNASEC-QRAQYSSY------LYNEPGEFRNATRLREIIAD 634

  Fly   556 YRSFQYSLTDYHFWLQGE----RFAFAETFVLDYFGLNPHRVLFYAVAQQLC---NRQTEIFAA- 612
            ......:...|..||:.:    |...|:. .|........::.|...||..|   :.|..|..:
  Fly   635 GSGLNLAFNAYLAWLEQQDHKLRPLLAKE-TLSELNFTNTQLFFIYFAQTRCWAKDNQDAILDSM 698

  Fly   613 ----------QLNRGYMNLPEFQEAFKCGAEKAMNPPSRCMI 644
                      .:|....|..||...|.|.....||...:|::
  Fly   699 PLMQHTPERWDVNGPLSNSAEFGREFGCALGTPMNSGDKCLV 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl9	NP_609815.1	GluZincin	62..>84	CDD:301352	8/23 (35%)
Nepl9	NP_609815.1	GluZincin	<579..642	CDD:301352	15/76 (20%)
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	149/767 (19%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	149/768 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454854
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.930