DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl9 and phex

DIOPT Version :9

Sequence 1:	NP_609815.1	Gene:	Nepl9 / 35020	FlyBaseID:	FBgn0032613	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001307259.1	Gene:	phex / 386969	ZFINID:	ZDB-GENE-030103-2	Length:	745	Species:	Danio rerio

Alignment Length:	773	Identity:	148/773 - (19%)
Similarity:	265/773 - (34%)	Gaps:	214/773 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VLFAIIQIVRSQNGEDSDSDTE-VEMDSEVESGQFFSHLYKSNLQQLVKIKNDSMDPCDDFYAHA 71
            :|.|:|.:.:..:.||...... ||     .:|...|.:            :.|:|||||||.:|
Zfish    35 LLIAVITVSQKASNEDLCLGPHCVE-----AAGSILSKM------------DQSVDPCDDFYQYA 82

  Fly    72 CGNF---DQTKEENSDDFLPPYLYNKQD----RMNFFTAEVGNFETIPGRLISQLYTECRKREER 129
            ||.:   :...|::|...:.|:|....|    .:.......|:.|.:  :....||..|......
Zfish    83 CGGWLRENPIPEDSSSYGIYPWLRQNVDLKLKELLEQPVRSGDIEAV--KKAKVLYASCMNESAL 145

  Fly   130 NVFTPTRLTSHWERMLDEIPFLARHKEVLSSWPFL------KHQWERRRLYGQLNWIVLSAQL-A 187
            .:             .|..|.|...|:....||.|      ..:|    :..|.|.:...||: :
Zfish   146 EI-------------EDANPLLKNLKQKEFRWPVLGDALGSSSRW----VESQFNLLETLAQIRS 193

  Fly   188 AHGLPTLLHIYFALD----TIYVSPMEE--LPCPSIADFQSSLSD----------------VLEG 230
            .|....|:.::.|.|    ..|:..:::  |...|..|:.::.::                |:.|
Zfish   194 QHSKSVLIRLFVAPDDKNSNQYIIKLDQASLSLSSREDYITNTTEAQMYREALLRLMVDVSVMLG 258

  Fly   231 RHHQVSR-----IISHEMRVLCREMRGELPLVRSLSQNTRTNTSRPGEEQLLLDENTMDYFQQYF 290
            ...|.:.     ::..||::    .:..:|.....|:|.....|....::.:.|.|.:.:.:...
Zfish   259 ASEQAAEAQMKSVLDFEMKL----AQIVIPYENRTSENMYNKYSLSKLQRTVPDFNWLGFVRAVI 319

  Fly   291 -------AALNFSEERLVGARKFPLDVEKITQAWEVLRHTETRIVYNYVMWQA----------RE 338
                   ..::.||:.:|.|.::..|:.|:..|      |:||.|.|||:|::          |.
Zfish   320 DTELYPDLKISSSEQVIVRAPQYFKDLFKLINA------TDTRTVANYVIWRSVFSRITTLSRRF 378

  Fly   339 QLRYPDCYRVSEEFERLLHAEYWQWHVLRRHLSREVALASYQLHTTR-FQKLRRSKL-------- 394
            ..||.|..||:.....|..    :|.....::...:..|:.:|...: ||:.::..:
Zfish   379 LYRYLDFARVTTGTTSLTP----RWDKCVNYVENTLIYAAGRLFVDKHFQEDKKHMMEELINGIR 439

  Fly   395 --------SRRDWYGHLWPASVEKKELQVARIL---QNHAENYLNITELNENYEGLKLEKNSFYA 448
                    ...:|...    ..::|.:..|..:   ..:.:..||.|.:||:.:.|......::.
Zfish   440 WAFIDILEKENEWMDE----ETKRKAIDKAHAVLPKVGYPDFILNDTYINEDIKRLAFTMTDYFG 500

  Fly   449 NLL------------ILRRAQLRHS-FVSP------YVDEEDVNQPAYFLRHFLHFVLLSLHRPT 494
            |::            .||:...|.. |.:|      |  ....||        :.|....|.:|.
Zfish   501 NVMQTLKFIAQSDIGWLRKTVPRTEWFTNPTTVNAFY--SSSTNQ--------IRFPAGELQKPF 555

  Fly   495 Y---------HYYA---------THGL--------------ELWRESRLLLDTDGHYTAMDCLER 527
            :         .|.|         |||.              :.|..|.:...|:.....:|  :.
Zfish   556 FWGLNYPRSLSYGAIGVIVGHELTHGFDNNGRKYDKDGNLDQWWSNSSINRFTEKTQCMID--QY 618

  Fly   528 QSFQHYDAKLAPIYRPLGSHEIAEIFQFYRSFQYSLTDYHFWLQGERFAFAETFVLDYFGLNPHR 592
            .|:...:|.|    ...|...:||........:.|...|..|::.||....|. :|...||..::
Zfish   619 NSYYWKEAGL----NVKGKRTLAENIADNGGIRESFRAYRRWVEKERGGVEEP-LLPGVGLTHNQ 678

  Fly   593 VLFYAVAQQLCNR-QTEIFAAQLNRG------------YMNLPEFQEAFKCGAEKAMN 637
            :.|.:.|...||. :.|....|:..|            ..|..||::||.|.....||
Zfish   679 LFFLSYAHVRCNAYRPEAARDQIQSGAHSPPKYRVIGAMSNFEEFRKAFNCPETSIMN 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl9	NP_609815.1	GluZincin	62..>84	CDD:301352	11/24 (46%)
Nepl9	NP_609815.1	GluZincin	<579..642	CDD:301352	19/72 (26%)
phex	NP_001307259.1	PepO	61..744	CDD:226118	141/742 (19%)
phex	NP_001307259.1	M13	72..743	CDD:189000	138/719 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580757
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.930