Protein Alignment Nepl9 and KEL

DIOPT Version :10

• Sequence 1: NP_609815.1
• Gene: Nepl9 / 35020
• FlyBaseID: FBgn0032613
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: XP_005250050.1
• Gene: KEL / 3792
• HGNCID: 6308
• Length: 744
• Species: Homo sapiens
• Alignment Length: 764
• Identity: 155/764 - (20%)
• Similarity: 249/764 - (32%)
• Gaps: 222/764 - (29%)

  Fly    10 FAIIQIVRSQNGEDSDSDTEVEMDSEVESGQFFSHLYKSNLQQLVKIKNDSMDPCDDFYAHACGN 74
            |:::.....||......:|.|.:|..       .|...|.        |.|:.||.||::.|||.
Human    73 FSVLLFYNFQNCGPRPCETSVCLDLR-------DHYLASG--------NTSVAPCTDFFSFACGR 122

  Fly    75 FDQTKEENSDDFLPPYLYNKQDRMNFFTAEVGNFETIPG---RLISQLYTECRKREERNVFTPTR 136
            ..:|  .||...|.....|:..|:    .||.| ...||   ....|.|..|..    .:.....
Human   123 AKET--NNSFQELATKNKNRLRRI----LEVQN-SWHPGSGEEKAFQFYNSCMD----TLAIEAA 176

  Fly   137 LTSHWERMLDEIPFLARHKEVLSSWPFLKHQWERRRLYGQL-NWIVLSAQLAAHGLPTLLH---- 196
            .|....::::|:    ....:...|..|......|.|..|. ::....|.|..|  |...|
Human   177 GTGPLRQVIEEL----GGWRISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPH--PASPHTPVI 235

  Fly   197 ------------------IYFALDTIYVSPMEELPC-----PSIADFQSSLSDVLEGRHHQVSRI 238
                              ||..:...|::.:.:|..     ||.....||||..:..|..|..|.
Human   236 QIDQPEFDVPLKQDQEQKIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSSLSISITSRLFQFLRP 300

  Fly   239 ISHEMRVLCREMRGEL-------------PLVRSLS--QNTRTNTSRPGEEQLLLDENTMDYFQQ 288
            :..      |..:|:|             |.:..||  |.|.|..|....:.|::.:  ::|.:
Human   301 LEQ------RRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHD--VEYLK- 356

  Fly   289 YFAALNFS---EERLVGARKFPLDVEKITQAWEVL------------RHTETRIVYNYVMWQARE 338
                 |.|   ||.|:..|.|       .|:..:|            :..|.|...:..:.:..|
Human   357 -----NMSQLVEEMLLKQRDF-------LQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTE 409

  Fly   339 Q------LRYPDCYRVSEE---FERLLHAEYWQWHVLRRHLSREVALASYQLHT-------TRFQ 387
            |      .|:..|  |.|.   ||..|.|.:     :|.........|:.:|.|       ||.:
Human   410 QPPMPARPRWMKC--VEETGTFFEPTLAALF-----VREAFGPSTRSAAMKLFTAIRDALITRLR 467

  Fly   388 KLRRSKLSRRDWYGHLWPASVEKKELQVARILQNHAENYLNITELNENYEGLKLEKNSFYANLLI 452
            .|        .|.........:.|..|: ::....:|..|......:.|..::|..:...:.|..
Human   468 NL--------PWMNEETQNMAQDKVAQL-QVEMGASEWALKPELARQEYNDIQLGSSFLQSVLSC 523

  Fly   453 LR--RAQLRHSFVSPY------VDEEDVNQPAYF--LRHFLHFVLLSLHRPTYH----------- 496
            :|  ||::..||:.|:      |...|||  ||:  ..|.:.|....|..|.:|
Human   524 VRSLRARIVQSFLQPHPQHRWKVSPWDVN--AYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGA 586

  Fly   497 ------------YYA-----------THGLELWRESRLLLDTDGHYTAMDCLERQSFQHYDAKLA 538
                        :|.           .|.|:   |:.|.|..  ||.|.....|.||......|.
Human   587 AGSIMAHELLHIFYQLLLPGGCLACDNHALQ---EAHLCLKR--HYAAFPLPSRTSFNDSLTFLE 646

  Fly   539 PIYRPLGSHEIAEIFQFYRSFQYSLTDYHFWLQGERFAFAETFVLDYFGLNPHRVLFYAVAQQLC 603
                  .:.::..:....:::...|..:|          .|| ||....|:|.::.|.:.||.:|
Human   647 ------NAADVGGLAIALQAYSKRLLRHH----------GET-VLPSLDLSPQQIFFRSYAQVMC 694

  Fly   604 NRQTEIFA--------AQLNRGYMNLPEFQEAFKCGAEKAMNPPSRCMI 644
            .:.:...:        .:::....:.|.|...|:|.....:||.|||.:
Human   695 RKPSPQDSHDTHSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQL 743

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl9	NP_609815.1	GluZincin	62..642	CDD:472708	143/708 (20%)
KEL	XP_005250050.1	M13	109..742	CDD:341056	144/710 (20%)