DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl9 and Nep3

DIOPT Version :9

Sequence 1:	NP_609815.1	Gene:	Nepl9 / 35020	FlyBaseID:	FBgn0032613	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001245775.1	Gene:	Nep3 / 33005	FlyBaseID:	FBgn0031081	Length:	786	Species:	Drosophila melanogaster

Alignment Length:	828	Identity:	144/828 - (17%)
Similarity:	267/828 - (32%)	Gaps:	279/828 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RWKL--QFV----LFAIIQIVRSQNGEDSDSDTEV----EMDSEVESGQFFSHLYKSNL---QQL 53
            :|.|  .||    :|.:: ||...:|..||:...|    ....:..||.....|.|..:   .::
  Fly    52 KWLLITTFVMAITIFTLL-IVLFTDGGSSDATKHVLHVQPHQKDCPSGNELPCLNKHCIFASSEI 115

  Fly    54 VKIKNDSMDPCDDFYAHACGNFDQTKEENSDDFLPP-----YLYNKQDRM------NFFTAEVGN 107
            :|..:.::|||||||.::|..:.:...      :|.     ..:.|.::|      |.......:
  Fly   116 LKSIDVTVDPCDDFYGYSCNQWIKNNP------IPEGKSTWGTFGKLEQMNQLIIRNVLEKPAKS 174

  Fly   108 FETIPGRLISQLYTECRKREERNVFTPTRLTSHWERM----LDEIPFLARHKEVLSSWPFLKHQW 168
            |::...|.....|..|...:|           |.|::    ::::..      .:..|...|..
  Fly   175 FKSDAERKAKVYYESCLDADE-----------HMEKLGAKPMNDLLL------QIGGWNVTKSG- 221

  Fly   169 ERRRLYGQLNWIVLSAQLAAHGLPTLLHIYFALDTIYVSPMEE----------------LPCPSI 217
                 |...||.:      .|.| .:||..:..:.::...:.|                |..|:
  Fly   222 -----YNVANWTM------GHTL-KILHNKYNFNCLFGWAIGEDDKNSSRHVIQIDQGGLTLPT- 273

  Fly   218 ADFQSSLSDVLEGRHHQVSRIISHEMRVLCREMRGELPLVRSLSQNTRTNTSRPGEEQLLLDENT 282
            ||:.::.:|    .|.:|.......|..:|                            :||..|.
  Fly   274 ADYYNNKTD----NHRKVLNEYIEYMTKVC----------------------------VLLGANE 306

  Fly   283 MDYFQQYFAALNFSEERLVG------------ARKFPLDVEKITQAWEVLRHT------------ 323
            .|...|....:|| |::|..            |...|:.:.::::....|..|
  Fly   307 SDARAQMIGVINF-EKKLANITIPLEDRRNEEAMYHPMQLRQLSKLAPFLNWTDHFDNAMQMVGR 370

  Fly   324 -----ETRIVY--------------------------NYVMWQAREQLR------YPDCYRVSEE 351
                 |..:||                          ||::|||...|.      :.|.|:...
  Fly   371 RVTDDEVVVVYAPDFLKNLSDIILKMEQTEEGKITLNNYLVWQAVRTLTSCLSKPFRDAYKGVR- 434

  Fly   352 FERLLHA----EYWQWHV---------------LRRHLSREVALASYQLHTTRFQKLRRSKLSRR 397
             :.|:.:    |.|::.|               :|:....|...|:.|: ....::..:..|...
  Fly   435 -KALMGSDGGEEIWRYCVSDTNNVVGFAVGAIFVRQAFHGESKPAAEQM-IAEIREAFKMNLQNL 497

  Fly   398 DWYGHLWPASVEKKELQVARILQNHAENYLNITELNENYEGLKLEKNSFYANLLILRRAQLRHSF 462
            .|..........:|..|::.:: ...:..|:..||::.|..|.:..|:::.|.:.:....|:.:.
  Fly   498 TWVDKQTREKAIEKANQISDMI-GFPDYILDPVELDKKYAELNITPNAYFENNIQVAIYNLKSNL 561

  Fly   463 VSPYVDEEDVNQP--------------AY---------FLRHFLHFVLLSLHRPTYHYYATHGLE 504
                   :.::||              ||         |....|......::.|....:...|:.
  Fly   562 -------KRLDQPVNKTNWGMTPQTVNAYYTPTKNQIVFPAGILQTPFFDINNPKSLNFGAMGVV 619

  Fly   505 LWRESRLLLDTDG-HYTAMDCLER----QSFQHYDAKLAPIYRPLGSHE---------------I 549
            :..|.....|..| .|.....:.|    :|.:.::.|...|.|....::               |
  Fly   620 MGHELTHAFDDQGREYDKFGNINRWWDSKSIERFNEKSECIARQYSGYKMNGRTLNGKQTLGENI 684

  Fly   550 AE---IFQFYRSFQYSLTDYHFWLQGERFAFAETFVLDYFGLN-PHRVLFY-AVAQQLCNRQT-E 608
            |:   :...|.::|.:.:|            .:..:|...||| .|..||: :.||..|:..| |
  Fly   685 ADNGGLKAAYHAYQRTKSD------------RDVDILKLPGLNLTHSQLFFVSFAQVWCSSTTDE 737

  Fly   609 IFAAQLNRG------------YMNLPEFQEAFKCGAEKAMNPPSRCMI 644
            ....|:.:.            ..|:.||.|.|:|...|.|||..:|.:
  Fly   738 TNLLQMEKDPHSPSQFRVIGTLSNMKEFAEVFQCKPGKRMNPTEKCEV 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl9	NP_609815.1	GluZincin	62..>84	CDD:301352	8/21 (38%)
Nepl9	NP_609815.1	GluZincin	<579..642	CDD:301352	23/77 (30%)
Nep3	NP_001245775.1	M13	123..784	CDD:189000	127/753 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454977
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840