DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl9 and Mmel1

DIOPT Version :9

Sequence 1:	NP_609815.1	Gene:	Nepl9 / 35020	FlyBaseID:	FBgn0032613	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_038811.2	Gene:	Mmel1 / 27390	MGIID:	1351603	Length:	766	Species:	Mus musculus

Alignment Length:	748	Identity:	148/748 - (19%)
Similarity:	251/748 - (33%)	Gaps:	224/748 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 QLVKIKNDSMDPCDDFYAHACGNF---DQTKEENSD----DFLPPYLYNKQDRMNFFTAEVGNFE 109
            ::::..:.|.:||::||.:|||.:   ....|.||.    |.|       :|.:......|....
Mouse    87 RILENMDQSRNPCENFYQYACGGWLRHHVIPETNSRYSVFDIL-------RDELEVILKGVLEDS 144

  Fly   110 TIPGR----LISQLYTEC------RKREERNVFTPTRLTSHWERMLDE------IPF-LARHKEV 157
            |...|    ....||..|      .||:...:.:..::...|...:|:      :.: |.|...|
Mouse   145 TSQHRPAVEKAKTLYRSCMNQSVIEKRDSEPLLSVLKMVGGWPVAMDKWNETMGLKWELERQLAV 209

  Fly   158 LSSWPFLKHQWERRRLYGQLNW--------IVLSAQLAAHGLPTLLHIYFALDTIYVSPMEELPC 214
            |:|      |:.||.|.....|        .|:.......|:|: ...||..|..:......|
Mouse   210 LNS------QFNRRVLIDLFIWNDDQNSSRHVIYIDQPTLGMPS-REYYFQEDNNHKVRKAYL-- 265

  Fly   215 PSIADFQSSLSDVLEGRHHQVSRIISHEMRVLCREMRGELPLVRSLSQNTRTNTSRPGEEQLLLD 279
                :|.:|::.:|     :..:.:|.|..::..||...|.|...|:..|.....|.....|...
Mouse   266 ----EFMTSVATML-----RKDQNLSKESAMVREEMAEVLELETHLANATVPQEKRHDVTALYHR 321

  Fly   280 ENTMDYFQQYFAALNFSEERL-------VGARKFPLDVEKITQAWEVLRHTE-------TRIVYN 330
            .:.|: .|:.|....|:....       |....|| |.|.:......|.:.|       .|.:.|
Mouse   322 MDLME-LQERFGLKGFNWTLFIQNVLSSVEVELFP-DEEVVVYGIPYLENLEDIIDSYSARTMQN 384

  Fly   331 YVMW---------------QAR------------EQLRYPDCYR-VSEEFERLLHAEYWQWHVLR 367
            |::|               :||            |::|:.:|.. |:...|..:.:.|     ::
Mouse   385 YLVWRLVLDRIGSLSQRFKEARVDYRKALYGTTVEEVRWRECVSYVNSNMESAVGSLY-----IK 444

  Fly   368 RHLSREVALASYQLHTTRFQKLRR---SKLSRRDWYGHLWPASVEKKELQVAR-------ILQNH 422
            |..|::......:|    .:|:|.   ..|...:|.........::|.:.:..       ||:::
Mouse   445 RAFSKDSKSTVREL----IEKIRSVFVDNLDELNWMDEESKKKAQEKAMNIREQIGYPDYILEDN 505

  Fly   423 ----AENYLNITELNENY--EGLKLEKNSFYANLLILRR----------AQLRHSFVSP----YV 467
                .|.|.::|...:.|  .||:..||:...:|..||.          |.:.::|.||    .|
Mouse   506 NKHLDEEYSSLTFYEDLYFENGLQNLKNNAQRSLKKLREKVDQNLWIIGAAVVNAFYSPNRNQIV 570

  Fly   468 DEEDVNQPAYFLR---HFLHFVLLSLHRPTYHYYATHGLELWRESRLLLDTDGHYTAMDCLERQS 529
            ....:.||.:|.:   ..|:|..:.:   ...:..|||.:   ::....|.:|:  .:|.....|
Mouse   571 FPAGILQPPFFSKDQPQSLNFGGIGM---VIGHEITHGFD---DNGRNFDKNGN--MLDWWSNFS 627

  Fly   530 FQHYDAKLAPIYRPLGSHEIAEIFQFYRSFQYSLTD--------------------------YHF 568
            .:|:.           ......|:| |.:|.:.|.|                          |..
Mouse   628 ARHFQ-----------QQSQCMIYQ-YGNFSWELADNQNVNGFSTLGENIADNGGVRQAYKAYLR 680

  Fly   569 W---------LQGERFAFAETFVLDYFGLNPHRVLFYAVAQQLCNRQTEIFAAQLNR-------- 616
            |         |.|....:|:.|.::|             ||..|......||.|..:
Mouse   681 WLADGGKDQRLPGLNLTYAQLFFINY-------------AQVWCGSYRPEFAVQSIKTDVHSPLK 732

  Fly   617 -----GYMNLPEFQEAFKCGAEKAMNPPSRCMI 644
                 ...|||.|.|||.|.....|:|..||.|
Mouse   733 YRVLGSLQNLPGFSEAFHCPRGSPMHPMKRCRI 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl9	NP_609815.1	GluZincin	62..>84	CDD:301352	9/24 (38%)
Nepl9	NP_609815.1	GluZincin	<579..642	CDD:301352	18/75 (24%)
Mmel1	NP_038811.2	PepO	89..766	CDD:226118	148/746 (20%)
Mmel1	NP_038811.2	M13	97..764	CDD:189000	145/735 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100