DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl9 and Mme

DIOPT Version :9

Sequence 1:	NP_609815.1	Gene:	Nepl9 / 35020	FlyBaseID:	FBgn0032613	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_036740.1	Gene:	Mme / 24590	RGDID:	3098	Length:	750	Species:	Rattus norvegicus

Alignment Length:	753	Identity:	143/753 - (18%)
Similarity:	248/753 - (32%)	Gaps:	231/753 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 QLVKIKNDSMDPCDDFYAHACGNFDQTKEENSDDFLPPYLYNKQDRMNFFTAEVGNFETIPGRLI 116
            :|::..:.|.:||.||:.:|||.                 :.|::.:...::...||:.:...|.
  Rat    68 RLIQNMDASAEPCTDFFKYACGG-----------------WLKRNVIPETSSRYSNFDILRDELE 115

  Fly   117 SQLYTECRKREERNVFTPTRLTSHWERMLDEIPFLARHKEVLSS-------WPFLKHQWERRRLY 174
            ..|....::.:..::....:..:.:...::|....:|..:.|.:       ||.....||  :.|
  Rat   116 VILKDVLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWE--QTY 178

  Fly   175 GQLNWIVLS--AQL-AAHGLPTLLHIYFALD----TIYV----SPMEELP--------------C 214
            | .:|....  ||| :.:|...|::.:...|    |.::    .|...||              |
  Rat   179 G-TSWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKEAC 242

  Fly   215 PSIADFQSSLSDVLEGRHHQVSRIISHEMRV------LCREMRGELPLVRSLSQNTRTNTSRPGE 273
            .:..||..|           |:|:|..|.|:      |..||...:.|.:.:: |..|......:
  Rat   243 TAYVDFMIS-----------VARLIRQEQRLPIDENQLSLEMNKVMELEKEIA-NATTKPEDRND 295

  Fly   274 EQLLLDENTMDYFQQYFAA---------LNFS--------------EERLVGARKFPLDVEKITQ 315
            ..||.::.|:...|..|:.         .||:              ||.:|.|.::      :|:
  Rat   296 PMLLYNKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEY------LTK 354

  Fly   316 AWEVLRHTETRIVYNYVMWQ---------AREQLRYPDCYRVSEE-FERLLHAEYWQWHVLRR-- 368
            ...:|.....|.:.|.:.|:         :|.       |:.|.. |.:.|:....:....||
  Rat   355 LKPILTKYSPRDLQNLMSWRFIMDLVSSLSRN-------YKESRNAFRKALYGTTSETATWRRCA 412

  Fly   369 ------------HLSREVALASYQLHTTR--FQKLRRSKLSRRD---WYGHLWPASVEKKELQVA 416
                        .|..|.|.|....|...  ..::|...:...|   |.........|:|.|.:.
  Rat   413 NYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIK 477

  Fly   417 R-------ILQNHAENYLNITELNENYEGLKLEKNSFYANLLILRRAQLRHSFVSPYVDEED--- 471
            .       |:.|  ||.||...|..||:..:..:| ...||...:..||:.  :...||:::
  Rat   478 ERIGYPDDIISN--ENKLNNEYLELNYKEEEYFEN-IIQNLKFSQSKQLKK--LREKVDKDEWIS 537

  Fly   472 ----VN-----------------QPAYFLRHFLHFVLLSLHRPTYHYYATHGLELWRESRLLLDT 515
                ||                 ||.:|          |..:.....|...|:.:..|.....|.
  Rat   538 GAAVVNAFYSSGRNQIVFPAGILQPPFF----------SARQSNSLNYGGIGMVIGHEITHGFDD 592

  Fly   516 DGHY-----TAMDCLERQSFQHY-DAKLAPIYR--------PLGSH---------EIAE---IFQ 554
            :|..     ..:|...:||..:: |.....:|:        ..|.|         .||:   |.|
  Rat   593 NGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQ 657

  Fly   555 FYRSFQYSLTDYHFWLQGERFAFAETFVLDYFGLNPHRVLFYAVAQQLCNRQTEIFAAQLNRGYM 619
            .||::|..:...           .|..:|....||..::.|...||..|......:|....:..:
  Rat   658 AYRAYQNYVKKN-----------GEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDV 711

  Fly   620 NLP-------------EFQEAFKCGAEKAMNPPSRCMI 644
            :.|             ||.:||.|.....|||..:|.:
  Rat   712 HSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRV 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl9	NP_609815.1	GluZincin	62..>84	CDD:301352	7/21 (33%)
Nepl9	NP_609815.1	GluZincin	<579..642	CDD:301352	18/75 (24%)
Mme	NP_036740.1	Stop-transfer sequence. /evidence=ECO:0000255	16..23
Mme	NP_036740.1	M13	79..748	CDD:341056	140/739 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100