Protein Alignment Nepl9 and ECE1

DIOPT Version :10

• Sequence 1: NP_609815.1
• Gene: Nepl9 / 35020
• FlyBaseID: FBgn0032613
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: XP_011539174.1
• Gene: ECE1 / 1889
• HGNCID: 3146
• Length: 778
• Species: Homo sapiens
• Alignment Length: 739
• Identity: 131/739 - (17%)
• Similarity: 245/739 - (33%)
• Gaps: 241/739 - (32%)

  Fly    60 SMDPCDDFYAHACGNFDQTKE---------------ENSDDFLPPYLYNKQDRMNFFTAEVGNFE 109
            ::|||.||:::|||.:.:...               |::...:...|.|.       ||.|...|
Human   126 TVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENS-------TASVSEAE 183

  Fly   110 TIPGRLISQLY-----TECRKREER--------------NVFTPTR----------LTSHWERML 145
            .     .:|:|     .|.|..|.|              |:..|..          :|:|:...
Human   184 R-----KAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTS- 242

  Fly   146 DEIPFLARHKEV------------------LSSWPFLKHQWERRR-LYGQLNWIVLSAQLAAHGL 191
               ||.:.:...                  |.|..:..::.|..: |.|.||::|...:|...|
Human   243 ---PFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGG- 303

  Fly   192 PTLLHIYFALDTIYVSPMEELPCPSIADFQSSLSDVL---EGRHHQVSRIISHEMRVLCREMRGE 253
                      |...:.|..:    .|.||:::|:::.   |.|..:  .:|.|  :|...|::..
Human   304 ----------DEEAIRPQMQ----QILDFETALANITIPQEKRRDE--ELIYH--KVTAAELQTL 350

  Fly   254 LPLVRSLSQNTRTNTSRPGEEQLLLDENTMDYFQQYF--AALNFSEERLVGARKFPLDVEKITQA 316
            .|.:                       |.:.:....|  ..:|.||..:|      .|.|.:.|.
Human   351 APAI-----------------------NWLPFLNTIFYPVEINESEPIVV------YDKEYLEQI 386

  Fly   317 WEVLRHTETRIVYNYVMWQ-AREQLRYPDCYRVSEEFERLLHAEY---------WQWHVLRRHLS 371
            ..::..|:..::.||::|. .|:...:.| .|..:..|:.:...|         |::.|.....:
Human   387 STLINTTDRCLLNNYMIWNLVRKTSSFLD-QRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENN 450

  Fly   372 REVALASYQLHTT--------------RFQKLRRSKLSRRDWYGHLWPASVEKKELQVARILQNH 422
            ...||....:..|              ..:|.....||...|.......|.::|...:..:: .:
Human   451 LGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMI-GY 514

  Fly   423 AENYLNITELNENYEGLKLEKNSFYANLL------------ILRRAQLR----------HSFVSP 465
            ....::..||::.:.......:.::.|.:            .||:|..|          :::.||
Human   515 PNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSP 579

  Fly   466 YVDE----EDVNQPAYFLR---HFLHFVLLSL---HRPTYHYYATHGLELWRESRLLLDTDGHY- 519
            ..:|    ..:.|..::.|   ..|:|..:.:   |..| |.:...|.|        .|.||:.
Human   580 TKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELT-HAFDDQGRE--------YDKDGNLR 635

  Fly   520 -----TAMDCLERQS------FQHYDAKLAPIYRPLGSHEIAEIFQFYRSFQYSLTDYHFWLQ-- 571
                 ::::..:||:      :.:|.....|:.   |.|.:.|........:.:...|..|::
Human   636 PWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVN---GRHTLGENIADNGGLKAAYRAYQNWVKKN 697

  Fly   572 GERFAFAETFVLDYFGLNPHRVLFYAVAQQLCNRQTEIFAAQLNRGYM----------------N 620
            |...:      |...||..:::.|...||..|:.:|   ....:.|.:                |
Human   698 GAEHS------LPTLGLTNNQLFFLGFAQVWCSVRT---PESSHEGLITDPHSPSRFRVIGSLSN 753

  Fly   621 LPEFQEAFKCGAEKAMNPPSRCMI 644
            ..||.|.|:|.....||||.:|.:
Human   754 SKEFSEHFRCPPGSPMNPPHKCEV 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl9	NP_609815.1	GluZincin	62..642	CDD:472708	130/733 (18%)
ECE1	XP_011539174.1	M13	127..776	CDD:341056	130/735 (18%)