DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl9 and ECE1

DIOPT Version :9

Sequence 1:	NP_609815.1	Gene:	Nepl9 / 35020	FlyBaseID:	FBgn0032613	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_011539174.1	Gene:	ECE1 / 1889	HGNCID:	3146	Length:	778	Species:	Homo sapiens

Alignment Length:	739	Identity:	131/739 - (17%)
Similarity:	245/739 - (33%)	Gaps:	241/739 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 SMDPCDDFYAHACGNFDQTKE---------------ENSDDFLPPYLYNKQDRMNFFTAEVGNFE 109
            ::|||.||:::|||.:.:...               |::...:...|.|.       ||.|...|
Human   126 TVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENS-------TASVSEAE 183

  Fly   110 TIPGRLISQLY-----TECRKREER--------------NVFTPTR----------LTSHWERML 145
            .     .:|:|     .|.|..|.|              |:..|..          :|:|:...
Human   184 R-----KAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTS- 242

  Fly   146 DEIPFLARHKEV------------------LSSWPFLKHQWERRR-LYGQLNWIVLSAQLAAHGL 191
               ||.:.:...                  |.|..:..::.|..: |.|.||::|...:|...|
Human   243 ---PFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGG- 303

  Fly   192 PTLLHIYFALDTIYVSPMEELPCPSIADFQSSLSDVL---EGRHHQVSRIISHEMRVLCREMRGE 253
                      |...:.|..:    .|.||:::|:::.   |.|..:  .:|.|  :|...|::..
Human   304 ----------DEEAIRPQMQ----QILDFETALANITIPQEKRRDE--ELIYH--KVTAAELQTL 350

  Fly   254 LPLVRSLSQNTRTNTSRPGEEQLLLDENTMDYFQQYF--AALNFSEERLVGARKFPLDVEKITQA 316
            .|.:                       |.:.:....|  ..:|.||..:|      .|.|.:.|.
Human   351 APAI-----------------------NWLPFLNTIFYPVEINESEPIVV------YDKEYLEQI 386

  Fly   317 WEVLRHTETRIVYNYVMWQ-AREQLRYPDCYRVSEEFERLLHAEY---------WQWHVLRRHLS 371
            ..::..|:..::.||::|. .|:...:.| .|..:..|:.:...|         |::.|.....:
Human   387 STLINTTDRCLLNNYMIWNLVRKTSSFLD-QRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENN 450

  Fly   372 REVALASYQLHTT--------------RFQKLRRSKLSRRDWYGHLWPASVEKKELQVARILQNH 422
            ...||....:..|              ..:|.....||...|.......|.::|...:..:: .:
Human   451 LGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMI-GY 514

  Fly   423 AENYLNITELNENYEGLKLEKNSFYANLL------------ILRRAQLR----------HSFVSP 465
            ....::..||::.:.......:.::.|.:            .||:|..|          :::.||
Human   515 PNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSP 579

  Fly   466 YVDE----EDVNQPAYFLR---HFLHFVLLSL---HRPTYHYYATHGLELWRESRLLLDTDGHY- 519
            ..:|    ..:.|..::.|   ..|:|..:.:   |..| |.:...|.|        .|.||:.
Human   580 TKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELT-HAFDDQGRE--------YDKDGNLR 635

  Fly   520 -----TAMDCLERQS------FQHYDAKLAPIYRPLGSHEIAEIFQFYRSFQYSLTDYHFWLQ-- 571
                 ::::..:||:      :.:|.....|:.   |.|.:.|........:.:...|..|::
Human   636 PWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVN---GRHTLGENIADNGGLKAAYRAYQNWVKKN 697

  Fly   572 GERFAFAETFVLDYFGLNPHRVLFYAVAQQLCNRQTEIFAAQLNRGYM----------------N 620
            |...:      |...||..:::.|...||..|:.:|   ....:.|.:                |
Human   698 GAEHS------LPTLGLTNNQLFFLGFAQVWCSVRT---PESSHEGLITDPHSPSRFRVIGSLSN 753

  Fly   621 LPEFQEAFKCGAEKAMNPPSRCMI 644
            ..||.|.|:|.....||||.:|.:
Human   754 SKEFSEHFRCPPGSPMNPPHKCEV 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl9	NP_609815.1	GluZincin	62..>84	CDD:301352	9/36 (25%)
Nepl9	NP_609815.1	GluZincin	<579..642	CDD:301352	19/78 (24%)
ECE1	XP_011539174.1	PepO	114..769	CDD:226118	126/729 (17%)
ECE1	XP_011539174.1	M13	127..776	CDD:189000	130/735 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910