DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl9 and nep-18

DIOPT Version :9

Sequence 1:	NP_609815.1	Gene:	Nepl9 / 35020	FlyBaseID:	FBgn0032613	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_494297.1	Gene:	nep-18 / 186911	WormBaseID:	WBGene00019343	Length:	701	Species:	Caenorhabditis elegans

Alignment Length:	760	Identity:	155/760 - (20%)
Similarity:	246/760 - (32%)	Gaps:	260/760 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LQQLVKIKNDSMDPCDDFYAHACGNFDQTKEENSDDFLPPYLYNKQDRMNFF--TAEVGNFETIP 112
            |..:...:|.|:|||:||:.|.||.:   .|...||....|:..||.....|  ..:...|.:.|
Worm    36 LAMIKNYQNASVDPCEDFFEHTCGRY---SEHVMDDNSWGYVQYKQLLYQVFAIARKTNKFNSKP 97

  Fly   113 GRLISQLYTEC--RKREERNVFTPTR-----------LTSHW-ERMLDEIPFLARHKEV------ 157
            ...:......|  ||..:.:.|...|           :..:| |...|....||::..:
Worm    98 NEQLRIFTKSCLDRKEMDEDTFQDLRNDIEERGGFPMIDPNWNEEKFDLSDMLAKYLSINRNRMG 162

  Fly   158 -LSSWPFLKHQWER--RRLYGQ------LNWIVLSAQLAAHGLPTLLHIYFAL------DTIYVS 207
             ||..|:...:..:  .|||..      .|| .:...:....:..:|.....|      :|||..
Worm   163 FLSVEPYAAIEGNKSVNRLYVSPGPHWVYNW-AMGISIYKDSVAFMLRRLLKLENRELNETIYDK 226

  Fly   208 PMEELPCPSIADFQSSLSD----VLEGRHHQVSRIISHEMRVLCREMRGELPLVRSLSQNTRTNT 268
            ...|| ....|:| |:|:|    .|:..:...||.::..::::     .|:..::.|....|..|
Worm   227 EFAEL-VQLEANF-STLADYRNLALDNDNMSKSRNLTDLVKMI-----PEIDWIKILKALARHGT 284

  Fly   269 SRPGEEQLLLDENTMDYFQQYFAALNFSEERLVGARKFPLDVEKITQAWEVLRHTETRIVYNYVM 333
            |...||: ||:..|:....:||    |.|.|
Worm   285 SEEDEEK-LLERVTVHGAGEYF----FGENR---------------------------------- 310

  Fly   334 WQAREQLRYPDCYRVSEEFERLLHAEYWQWHVLRRHLSREVALASYQLHTTRFQKLRRSKLSRRD 398
                      :..|::.|..:...|.|.   |:|:.:  :|||..|.....|..|
Worm   311 ----------ELARIATETPKSALANYL---VVRQLI--DVALYFYDKDQPRQNK---------- 350

  Fly   399 WYGHLWPASVEKKEL---QVARIL------------QNHAENYLNITEL------------NENY 436
            :|.|     |:::..   |||...            |...||...|.|:            .||
Worm   351 FYNH-----VDQQSFCATQVASFFPMPSMNVFIESSQFKIENLKVIEEMFVKIKAEYEQIFTEN- 409

  Fly   437 EGLKLEKNSFYANLLILRRAQLRHSF-VSPYVDEEDVNQPAYFLRHFLHFVLLSLHRPTYHYYAT 500
            |.|:||...|    ||.:...:...| :..|.:.:.:.:..|...:|     |....|...|
Worm   410 EYLELEIREF----LIRKLNAIDGKFGLDQYTEGKPLLEKMYETLNF-----LDTDSPWQVY--- 462

  Fly   501 HGLELWRE-SRLLLDTDGHYTAMDCLERQSF----------QHYDAKLAPIYRP----------- 543
              :::||. |..|::...|.|.:|.:..:.|          .|:...|..:..|
Worm   463 --MKMWRHWSEQLVEHIVHDTPLDPVNLKMFGTHAAYQPYPNHFYINLPYLTYPWMDADFPANTN 525

  Fly   544 ---LG---SHEIAEIFQFY--------RSFQYSLTD--------------------------YHF 568
               ||   .|||...|..:        |..||..|:                          |.|
Worm   526 YGYLGYVIGHEIGHAFDHFHRKLDESGRQQQYWFTETNSSNTEYELREKCLRDQYSAYKEPGYDF 590

  Fly   569 WLQGE-------------RFAF--------AETFVLDYFGLNPHRVLFYAVAQQLCN-------- 604
            ::.|.             |.||        .:.|.|....::..::.||..|.:.|:
Worm   591 FMNGTHCRYEIAGDHMGIRTAFRVFEKVKKEDRFRLPGLEMSEEQLFFYNYAFRQCDVYNPNKLP 655

  Fly   605 -----RQTEIFAAQLNRGYMNLPEFQEAFKCGAEKAMNPPSRCMI 644
                 ||......::|....|:|||.|||.|.....|||..:|.:
Worm   656 RNMLARQHPTNRYRVNGVIQNIPEFAEAFNCPKNSPMNPEMKCKL 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl9	NP_609815.1	GluZincin	62..>84	CDD:301352	9/21 (43%)
Nepl9	NP_609815.1	GluZincin	<579..642	CDD:301352	20/75 (27%)
nep-18	NP_494297.1	PepO	42..692	CDD:226118	150/744 (20%)
nep-18	NP_494297.1	M13	47..699	CDD:189000	151/746 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900