DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl9 and nep-1

DIOPT Version :9

Sequence 1:	NP_609815.1	Gene:	Nepl9 / 35020	FlyBaseID:	FBgn0032613	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_496490.2	Gene:	nep-1 / 174787	WormBaseID:	WBGene00013926	Length:	754	Species:	Caenorhabditis elegans

Alignment Length:	753	Identity:	155/753 - (20%)
Similarity:	265/753 - (35%)	Gaps:	222/753 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 YKSNLQQLVKIKNDSMDPCDDFYAHAC----------------GNFDQTKEENSDDFLPPYLYNK 94
            |:...:.|.|..|.|:||||||:.:||                ..|..|:|:...:....|
Worm    69 YQEASRLLQKSLNLSLDPCDDFFEYACRAWVDSHPIPDDLTSYSQFTATREKVLAEMRKLY---- 129

  Fly    95 QDRMNFFTAEVGNFETIPGRLISQLYTECRKREERNV--------------FTPTRLTSHW-ERM 144
            :|..:..|:     ::|  .||.|:|..|...|:.|.              :.|......| |..
Worm   130 EDNTSIPTS-----KSI--ALIKQIYNTCMDTEKHNAVGARDLLEKIKTYGYWPMVHNEKWREST 187

  Fly   145 LDEIPFLA---RHKEVLSSWPFLKHQWER---RRLYGQLNWIVLSAQLAAHGLPTLLHIYFALDT 203
            .|....|:   :.::|...:.|...:..|   |||        ||....:.||......|:..:.
Worm   188 FDLTKLLSNTIQSRDVSVFFDFGPAEDSRNVSRRL--------LSFDQGSLGLGYSTRDYYLDEK 244

  Fly   204 IYVSPMEELPCPSIADFQSSLSDVLEGRHHQVSRIISHEMRVLCREMRGELPLVRSLSQNTRTNT 268
            .|...|:.....:|...:....|.  |.....|:|.|....::..|......||   ::..|.|.
Worm   245 KYEKQMKAYRKYTIGKVRYYTEDA--GMAVNESKIESDVDEIIAFEKEWAQILV---AEEDRRNY 304

  Fly   269 SRPGEEQLLLDENTMDYFQQYFAALNFSEERLVGARKFPL-------------DVEKITQAWEVL 320
            ::      |.:....|..::|.:.:::.:..| ....|.:             |||.:.:...:|
Worm   305 TK------LYNVRRFDDLKEYMSIIDWKKLTL-STTPFLVHSYLKTNPSIIISDVEYLQKMNTLL 362

  Fly   321 RHTETRIVYNYVM------W---------------------QAREQLRYPDCYRVSEEFERLLHA 358
            ::|:.|||.||::      |                     :.:.|.|:.||  ||....:|.:|
Worm   363 QNTDPRIVTNYILLRWAGSWSQEIGKKYEDLQQEFAFQMYGRKQRQPRWKDC--VSSAGGKLSYA 425

  Fly   359 EYWQWHVLRRHLSREVALASYQLHTTRFQKLRRSKLSRRDWYGHLWPASVEKKELQVA-RILQ-- 420
            ....:  :|::........:..: .|..|:..|:.:...||    ..|..:|..|:.| ::|:
Worm   426 SGSMY--VRKYFDANAKNTTLDM-ITDLQEAFRNMMHANDW----MDAETKKYALEKADQMLKQI 483

  Fly   421 NHAENYLNITELNENYEGLK----------LEK-----NSFYANLLI--------LRRAQLRHSF 462
            .:.:..||..:|::.|:||:          :||     |:||...|:        :..|.:.::|
Worm   484 GYPDFILNDEKLDDWYKGLEGAPEDSFSQLVEKSIQWRNNFYYRRLLEPVNRFEFISSAAVVNAF 548

  Fly   463 VSPYVDEEDVNQPAYFLRHFLHFVLLSLHRPTYH-----------------YYATHGLELWRESR 510
            .||             .|:.:.|....|.:|.:.                 :..|||.:   ::.
Worm   549 YSP-------------TRNAIAFPAGILQQPFFDARFPKALNYGGIGAVIGHEITHGFD---DTG 597

  Fly   511 LLLDTDGHY-------TAMDCLERQSF---QHYDAKL----APIYRPLGSHE-------IAEIFQ 554
            ...|..|:.       |:....||...   |:.|.||    ..|...|...|       |.:.|:
Worm   598 RQFDNVGNLRDWWDNTTSSKFNERTQCIIEQYADVKLRGTDLRINGKLTQGENIADNGGIKQAFK 662

  Fly   555 FYRSFQYSLTDYHFWLQGERFAFAETFVLDYFGLNPHRVLFYAVAQQLCNRQT------------ 607
            .|:|:.            |:....|..:..:..|...::.|...||..|..:|
Worm   663 AYKSYL------------EKHGGQEARLPQFESLTNEQLFFVGYAQVWCGAKTPETKTLLLLTDP 715

  Fly   608 -EIFAAQLNRGYMNLPEFQEAFKCGAEKAMNPPSRCMI 644
             ....|::|....|.|||.|||||.|...|||..||::
Worm   716 HSPETARVNTVLTNQPEFAEAFKCPAGSPMNPTKRCVV 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl9	NP_609815.1	GluZincin	62..>84	CDD:301352	11/37 (30%)
Nepl9	NP_609815.1	GluZincin	<579..642	CDD:301352	22/75 (29%)
nep-1	NP_496490.2	PepO	80..754	CDD:226118	152/742 (20%)
nep-1	NP_496490.2	M13	85..751	CDD:189000	148/733 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810