DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl9 and nep-9

DIOPT Version :9

Sequence 1:	NP_609815.1	Gene:	Nepl9 / 35020	FlyBaseID:	FBgn0032613	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_494531.2	Gene:	nep-9 / 173683	WormBaseID:	WBGene00017554	Length:	700	Species:	Caenorhabditis elegans

Alignment Length:	719	Identity:	140/719 - (19%)
Similarity:	246/719 - (34%)	Gaps:	222/719 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 QQLVKIKNDSMDPCDDFYAHACGNF-DQTKEENSDDFLPPYLYNKQDRMNFFTAEVGNFETIPGR 114
            |:|....:.:...|:|||...|.|: |....:...|.......||..| .|...:...|.:....
Worm    74 QELKAYSDTATKSCEDFYKATCENYKDHQALDRHRDCKKRKAVNKLVR-GFLQRDESTFTSESES 137

  Fly   115 LISQLYTECRKREERNVFTPTRLTSHWERMLDEIPFLARHKEVLSSWPFLKHQWERRRLYGQLNW 179
            .|..::.:|.:.        :|.||:    ||    :.:..:.:.|||.|:|.|:.    ...|.
Worm   138 AIKLIFGKCDEL--------SRNTSY----LD----IFKDIKKIGSWPVLEHNWKD----SMFNL 182

  Fly   180 IVLSAQLAAHG----------LPTLLHIYFALDTIYVSPMEE-------------LPCPSIADFQ 221
            ..:.|:|...|          |..|...:||   ::||..:|             |....|...:
Worm   183 DDVIAKLVKLGSTDFGLFKLELRKLAFGHFA---VFVSSKQEQNIHQLEKTILGILKANGIQQDR 244

  Fly   222 SSLSDVLEG----RHHQVSRIISHEMRVLCREMRGELPLVRSLSQNTRTNTSRPGEEQLLLDENT 282
            ..|||.|:.    ::| :......|..:..|...|.  :|.:|..::.|.       |:.|....
Worm   245 KELSDDLKDYSDFKNH-LKEFYQEETYIEYRLYAGS--IVENLGISSLTT-------QMALKSTG 299

  Fly   283 MDYFQQY-------FAALNFSEERLVGARKFPLDVEKITQAWEVLRHTETRIVYNYVMWQAREQL 340
            :|.|...       .::|.|.||..:|.               :::.|..|.:.|::::...:.:
Worm   300 LDVFNHVNQRTLITNSSLFFGEENNLGM---------------IIQKTPKRTLANFLIFHFIDVM 349

  Fly   341 R--YPDCYRVSEE--FERLLHAEYWQWHVLRRHLSRE------VALASYQLHTTRFQKLRRSKLS 395
            .  ..:..:..:|  .:.|..|..   .||.|:...|      |.:|. .|.|...:.:..|...
Worm   350 TTDLANATKACKETLIDLLPRASI---QVLSRNFVNEDAQDDMVKMAQ-DLKTKITEMIDNSPFF 410

  Fly   396 RRDWYGHLWPASVEKKELQVARILQNHAENYLNITE-----LNENYEGLKL-EKNSFYANLLILR 454
            .:  :..::.|..:||.:|..:.:.       .:||     |:.::|.|.| ..:|.|..:..||
Worm   411 TK--FHLVFDAEEQKKLIQKVKAIG-------IVTEYPQEVLDRDFERLNLTPSDSIYRTIQKLR 466

  Fly   455 RAQ----LRH-------------------------SFVSPYVDEE--DVNQPAYFLRHFLHFVLL 488
            |.:    :.|                         :..:|.:|..  |.:.|.|..:..:.|:|
Worm   467 RLRSEQLIEHLGGDLDPTDTRVWGSAHYDQTTNNLTIFAPIIDGPYFDTSYPNYVNQFLMGFIL- 530

  Fly   489 SLHRPTYHYYATHGLELWR---ESRLLLDTDGHYTAMDCLERQSFQHYDAKL---APIY----RP 543
                         |.||.|   ..|:..|..|.  ..:.|:.:|.:.:|..|   |..|    .|
Worm   531 -------------GRELGRSLDSVRIRKDEKGQ--TENWLKPESLKRFDEHLKCWAEKYDKSADP 580

  Fly   544 LGSHE--IAEIFQFYRSFQYSLTDYHFWLQGERFA---------------------FAETFVLDY 585
            |.|..  |.:|...|             :|.|.||                     ..|||.:
Worm   581 LKSESKGIRQIEGRY-------------IQNEMFADFIGHEASWRAFMKLDVKNEEVLETFKV-- 630

  Fly   586 FGLNPHRVLFYAVAQQLC------------NRQTEIFAAQLNRGYMNLPEFQEAFKCGAEKAMNP 638
              :...|:.|...|...|            ....:.::.::|..:.|:|:|..||:|.::..|||
Worm   631 --IKLRRMFFNVQALYFCRPPSGSTDWLSYQEHHQHYSFRVNGAFKNMPQFALAFECASDDDMNP 693

  Fly   639 PSRC 642
            .::|
Worm   694 QNKC 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl9	NP_609815.1	GluZincin	62..>84	CDD:301352	7/22 (32%)
Nepl9	NP_609815.1	GluZincin	<579..642	CDD:301352	17/74 (23%)
nep-9	NP_494531.2	M13	87..698	CDD:189000	138/706 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900