DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl9 and Ecel1

DIOPT Version :9

Sequence 1:	NP_609815.1	Gene:	Nepl9 / 35020	FlyBaseID:	FBgn0032613	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001264854.1	Gene:	Ecel1 / 13599	MGIID:	1343461	Length:	775	Species:	Mus musculus

Alignment Length:	748	Identity:	146/748 - (19%)
Similarity:	259/748 - (34%)	Gaps:	256/748 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 SMDPCDDFYAHACGNFDQTKEENSDDFLPPYLYNKQDRMNFFT-AEVG--NFETI---------- 111
            |:|||.|||:.|||.:.:...      :|      .|::.:.| |.:|  |.|.:
Mouse   120 SIDPCQDFYSFACGGWLRRHA------IP------DDKLTYGTIAAIGEQNEERLRRLLARPTGG 172

  Fly   112 PG----RLISQLYTECRKREE------------------------------------------RN 130
            ||    |.:...:..|....|                                          :.
Mouse   173 PGGAAQRKVRAFFRSCLDMREIERLGPRPMLEVIEDCGGWDLGGAADRPGAARWDLNRLLYKAQG 237

  Fly   131 VFTPTRL-----------TSHWERMLDE----IP----FLARHKE---VLSSWPFLKHQWERRRL 173
            |::...|           :|.:...:|:    :|    :||:.:|   :|:::          |:
Mouse   238 VYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEESEKILAAY----------RV 292

  Fly   174 YGQLNWIVLSAQLAAHGLPTLLHIYFALDTIYVSPMEELPCPSIADFQSSLSDVLEGRHHQVSRI 238
            :.|....:|.|.........:|.:...|..|.||..::|.    .|..|:.:.|..|   |:.:|
Mouse   293 FMQRLLRLLGADAVEQKAQEILQLEQRLANISVSEYDDLR----RDVSSAYNKVTLG---QLQKI 350

  Fly   239 ISHEMRVLCREMRGELPLVRSLSQNTRTNTSRPGEEQLLLDENTMDYFQQYFAALNFSEERLVGA 303
            |.|.                              :.:.|||:    .||:     :||||..|
Mouse   351 IPHL------------------------------QWKWLLDQ----IFQE-----DFSEEEEV-- 374

  Fly   304 RKFPLDVEKITQAWEVLRHTETRIVYNYVMWQA----REQLRYPDCYRVSEEFERLLH--AEYWQ 362
              ..|..:.:.|..:::|.|..||::||::|:.    .|.|..|        |...||  |:..:
Mouse   375 --VLLATDYMQQVSQLIRSTPRRILHNYLVWRVVVVLSEHLSSP--------FREALHELAKEME 429

  Fly   363 WHVLRRHLSR----------EVALASYQLH-------TTRFQKLRR-------SKLSRRDWYGHL 403
            .:...:.|:|          .:||.:..:|       ..:.|:|..       .:|...||....
Mouse   430 GNDKPQELARVCLGQANRHFGMALGALFVHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAQ 494

  Fly   404 WPASVEKKELQVARILQNHAENYLNITELNENYEGLKLEKNSFYANLL--ILRRAQLRHSFVSPY 466
            ..|:...| ||...::..:.:..|....:::.|| .::.:.:::.|:|  |....||....:...
Mouse   495 TKAAARAK-LQYMMVMVGYPDFLLKPEAVDKEYE-FEVHEKTYFKNILNSIRFSIQLSVKKIRQE 557

  Fly   467 VDEEDVNQP-----AYFLRHFLHFVL-LSLHRPTYH------------------YYATHGLELW- 506
            ||:.....|     ||:|.:....|. ..:.:||.:                  :..|||.:.|
Mouse   558 VDKSSWLLPPQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWG 622

  Fly   507 ----RESRLL---LDTD-GHY-TAMDCLER--QSFQHYDAKLAPIYRPLGSHEIAEIFQFYRSFQ 560
                |...||   .:|. .|: ...:|:.|  .:|..|:.::.      |.|.:.|........:
Mouse   623 GQYDRSGNLLHWWTETSYSHFLRKAECIVRLYDNFTVYNQRVN------GKHTLGENIADMGGLK 681

  Fly   561 YSLTDYHFWLQGERFAFAETFVLDYFGLNPHRVLFY-AVAQQLCNRQ----------TEIFAAQL 614
            .:...|..|:: |.........|.|    .|..||: |.||..|.::          |:..|.:.
Mouse   682 LAYYAYQKWVR-EHGPEHPLHRLKY----THNQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEH 741

  Fly   615 NRGYMNLPEFQE---AFKCGAEKAMNPPSRCMI 644
            .|...::.:|:|   ||.|..:..|||..:|.:
Mouse   742 YRVLGSVSQFEEFGRAFHCPKDSPMNPVHKCSV 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl9	NP_609815.1	GluZincin	62..>84	CDD:301352	9/21 (43%)
Nepl9	NP_609815.1	GluZincin	<579..642	CDD:301352	20/76 (26%)
Ecel1	NP_001264854.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..52
Ecel1	NP_001264854.1	M13	121..773	CDD:341056	144/744 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000