DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl9 and EEF1AKMT4-ECE2

DIOPT Version :9

Sequence 1:	NP_609815.1	Gene:	Nepl9 / 35020	FlyBaseID:	FBgn0032613	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_055508.3	Gene:	EEF1AKMT4-ECE2 / 110599583	HGNCID:	53615	Length:	883	Species:	Homo sapiens

Alignment Length:	744	Identity:	146/744 - (19%)
Similarity:	246/744 - (33%)	Gaps:	245/744 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 DSMD----PCDDFYAHACGNFDQTKEENSDDFLPPYLYNKQDRMNFFTAEVGNFETIPGRLI--- 116
            :|:|    ||:|||..:||.:.:...      ||    :.:.|.|.|.:.....:.|...|:
Human   226 ESLDRGVSPCEDFYQFSCGGWIRRNP------LP----DGRSRWNTFNSLWDQNQAILKHLLENT 280

  Fly   117 ------------SQLYTECR--KREERNVFTPTR----------LTSHWERMLDEIPFLARHKEV 157
                        .:.|..|.  :|.|.....|.|          :|..|    |:..|:...|.|
Human   281 TFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGPW----DQDNFMEVLKAV 341

  Fly   158 LSSW---PFLKHQWERRRLYGQLNWIVLSAQLAAHGLPTLLHIYFALDTIYVSPMEELPCPSIAD 219
            ..::   ||.                                      |:|:|          ||
Human   342 AGTYRATPFF--------------------------------------TVYIS----------AD 358

  Fly   220 FQSSLSDVLE---------GRHHQVSRIIS-----------HEMRVLC--------REMRGELPL 256
            .:||.|:|::         .|.:.::|..:           .|:.:|.        .:|:..|.|
Human   359 SKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLEL 423

  Fly   257 VRSLSQNTRTNTSRPGEEQLL----LDE-----NTMDYFQQYFAALNFSEERLVGARKFPLDV-- 310
            ...|:..|.....|..||::.    :.|     .:||:.:    .|:|....|..:...|:.|
Human   424 EIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLE----FLSFLLSPLELSDSEPVVVYG 484

  Fly   311 -EKITQAWEVLRHTETRIVYNYVMWQAREQLRYPDCYRVSEEFERLLHAEY---------WQWHV 365
             :.:.|..|::..||..|:.||::|...::.......|.....|:||...|         ||..:
Human   485 MDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCI 549

  Fly   366 LRRHLSREVALASYQLHTT---RFQKLRRSKLSR-----RDWYGHL-WPASVEKKELQVAR---- 417
            .....:...||.|..:..|   :.:::....:|.     .:..|.| |   :::|..|.|:
Human   550 SNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQLVW---MDEKTRQAAKEKAD 611

  Fly   418 ---ILQNHAENYLNITELNENYEGLKLEKNSFYANLLIL-------RRAQLRHSFVSPYVDE--- 469
               .:....:..|...||::.|:|.::.::||:.|:|.|       ...|||.   .|..|:
Human   612 AIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRK---PPSRDQWSM 673

  Fly   470 --EDVNQPAYFL--RHFLHFVLLSLHRPTY----------------------HYYATHGLELWRE 508
              :.||  ||:|  ::.:.|....|..|.|                      |.:...|.|..:|
Human   674 TPQTVN--AYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKE 736

  Fly   509 SRL-------LLDTDGHYTAMDCLERQSFQHYDAKLAPIYRPLGSHEIAEIFQFYRSFQYSLTDY 566
            ..|       .|....::||  |:|.| :..|.....   |..|...:.|........:.:...|
Human   737 GNLRPWWQNESLAAFRNHTA--CMEEQ-YNQYQVNGE---RLNGRQTLGENIADNGGLKAAYNAY 795

  Fly   567 HFWLQGERFAFAETFVLDYFGLNPHRVLFYAVAQQLCNRQTEIFAAQLNRGYMNLP--------- 622
            ..||:    ...|...|...||..|::.|...||..|:.:|   ....:.|.:..|
Human   796 KAWLR----KHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRT---PESSHEGLVTDPHSPARFRVL 853

  Fly   623 -------EFQEAFKCGAEKAMNPPSRCMI 644
                   :|...|.|.....|||...|.:
Human   854 GTLSNSRDFLRHFGCPVGSPMNPGQLCEV 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl9	NP_609815.1	GluZincin	62..>84	CDD:301352	8/25 (32%)
Nepl9	NP_609815.1	GluZincin	<579..642	CDD:301352	18/78 (23%)
EEF1AKMT4-ECE2	NP_055508.3	Methyltransferase-like region. /evidence=ECO:0000305	1..160
		Methyltransf_25	62..>128	CDD:316196
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:P0DPD7	88..89
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:P0DPD7	113..114
		M13	232..881	CDD:189000	143/735 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910