DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl9 and kel

DIOPT Version :9

Sequence 1:	NP_609815.1	Gene:	Nepl9 / 35020	FlyBaseID:	FBgn0032613	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_005157998.1	Gene:	kel / 101882278	ZFINID:	ZDB-GENE-110411-118	Length:	759	Species:	Danio rerio

Alignment Length:	769	Identity:	147/769 - (19%)
Similarity:	239/769 - (31%)	Gaps:	283/769 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 SMD----PCDDFYAHACG------NFDQTKEENSDDFLPPYLYNKQDRM------------NFFT 102
            :||    || |::..|||      |.|:.:.:..        .||...:            :.::
Zfish    93 AMDPFSRPC-DYFLFACGAGGSSTNRDRQRVKGE--------VNKHSEVRTRGLIEMRRGTDGWS 148

  Fly   103 AEVGNFETIPGRLISQLYTECR---------------KREERNVFTPTRLTSHWERMLDEIPFLA 152
            ...|..:|.|.|. :.|.|..:               :::.:|.|.........|:|..| |||.
Zfish   149 KSDGQLKTFPDRQ-TALLTAIKEILEAPDEAVSMGAAEQKAKNFFKSCMNAESREKMGSE-PFLT 211

  Fly   153 RHKEVLSSWPFLKHQWERRRLYGQLNWIVLSAQLAAHGLPTLLHIYFALDTIYVSPMEELPCPSI 217
            ..:: |..|. :...|.:......|  .:|..|.:.          |....:||.|
Zfish   212 LLQQ-LGGWA-VSGVWNQTDFNSTL--ALLMGQYST----------FPFFNVYVGP--------- 253

  Fly   218 ADFQSSLSDVLEGRHHQVSRIISHEMRVLCREMRGELPLV-RSLSQNTRTNTS--RP-----GEE 274
               :.|.......||:           :...|...:.|:. .|.:|..:.||.  ||     |:.
Zfish   254 ---EPSEEQSASNRHY-----------IQIDEPHFQFPIEWNSKTQKAKANTRYLRPFYSACGQY 304

  Fly   275 QLLL----DENT--------------------------------------------MDY---FQQ 288
            .:||    |..|                                            :|:   .|.
Zfish   305 LVLLGVPSDRTTQHCGLFVSLSTTLAVATFPLPYRLSQKLLYRRTTIQELQTLAPAVDWLACLQA 369

  Fly   289 YFAALNFSEERLVGARKFP--LDVEKITQAWEV-------------------------LRHTETR 326
            .|..|..|:..:|.....|  :.:.|....|:|                         |.....:
Zfish   370 TFQPLLISKSDIVLVHNLPYIIHMSKTIHLWQVQHELMGTGPLNTYMIFSLLQTLIPALDSRFFQ 434

  Fly   327 IVYNYVMWQAREQLRYPDCYRVSEEFER-----LLHAEYWQWHVLRRHLSREVALASYQLHTTRF 386
            |:.||.:.....| ..|..:|..::.||     |.||      :..:|..:|.......::::..
Zfish   435 IMRNYSIATGDTQ-EMPHWWRCVQQTERGFDTLLSHA------IREKHAQKEAEELIQDVYSSLK 492

  Fly   387 QKLRRSKLSRRDWYGHLWPASVEKKELQV--------ARILQNHAENYLNITELNENYEGLKLEK 443
            :||  :.||.||          ||:...:        .||..|  .|.|:.||||..||.:.|.:
Zfish   493 KKL--TDLSWRD----------EKESDFILNKINSLNPRISTN--TNNLSYTELNHLYEKVILNE 543

  Fly   444 NSFYAN---LLILRR----------AQLRHSFVSPYVDEEDVNQP-AYFLRHFLHFVLLSLHRPT 494
            ..|::|   :|:|.:          .|.....::|::...|:..| ..|:..|.|     ...|.
Zfish   544 EDFFSNYLQILLLEQKSRARLLSLGTQTEGLSMTPFISGNDIIVPVGMFVSPFFH-----SSYPR 603

  Fly   495 YHYYATHGLELWRESRLLLDTDGHYTAMDCLERQS---FQHY----------DAKLAPIYRPLGS 546
            ...|.|.|..:.::...||..| .||.....|.:|   :.||          ||    .|.|  |
Zfish   604 ALNYGTLGSLMAKDLLHLLLPD-IYTKAKNPETESLCVWSHYLSVTKGPGWGDA----FYLP--S 661

  Fly   547 HEIAEIFQFYRSFQYSLTDYHF---------WLQGERFAFAETFVLDYFGLNPHRVLFYAVAQQL 602
            .:..|::..|.:.|.:|..|..         .|.|  |::...|:..:             .:..
Zfish   662 SKQQEVWVQYSALQVALDAYKMSFKRYLADSSLPG--FSYVHLFLSSF-------------TKVT 711

  Fly   603 CNRQTEIFAAQLNRGYMNL-PEFQEAFKCGAE-------KAMNPPSRCMINMCE 648
            |:  |:.:     |.:|.| |.|.....|...       ..||.|......||:
Zfish   712 CD--TDAY-----REFMPLEPSFLVTVLCSNSGLCPKPLTCMNKPQSFPAEMCQ 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl9	NP_609815.1	GluZincin	62..>84	CDD:301352	9/31 (29%)
Nepl9	NP_609815.1	GluZincin	<579..642	CDD:301352	12/70 (17%)
kel	XP_005157998.1	GluZincin	99..>620	CDD:301352	109/594 (18%)
kel	XP_005157998.1	GluZincin	583..>721	CDD:301352	35/171 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100