DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG13282 and LPL

DIOPT Version :10

Sequence 1:NP_609814.1 Gene:CG13282 / 35019 FlyBaseID:FBgn0032612 Length:484 Species:Drosophila melanogaster
Sequence 2:NP_000228.1 Gene:LPL / 4023 HGNCID:6677 Length:475 Species:Homo sapiens


Alignment Length:282 Identity:86/282 - (30%)
Similarity:133/282 - (47%) Gaps:50/282 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 DPDVKYYIYTRHNPMDRQCLHIDESLEKSNLTDSYFNPRYPTKIIIHGYNSDMFLHPLQQMREEY 138
            |.:.|:.:.|..:..:..| |:...:.:|..| .:||....|.::|||:.       :..|.|.:
Human    36 DIESKFALRTPEDTAEDTC-HLIPGVAESVAT-CHFNHSSKTFMVIHGWT-------VTGMYESW 91

  Fly   139 LAK---------ADYNIIYVDWSILSPGPCYISAVHNTKHAGTCTAQLVERLVETGN---TDIHV 191
            :.|         .|.|:|.|||...:.....:||.: ||..|...|:.:..:.|..|   .::|:
Human    92 VPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGY-TKLVGQDVARFINWMEEEFNYPLDNVHL 155

  Fly   192 IGFSLGAQVPNYIARNLSSFMLPRITGLDPAMPLFITSGKADKLDPSDASYVDVIHTNALVQGKM 256
            :|:||||.... ||.:|::..:.||||||||.|.|..:....:|.|.||.:|||:||  ..:|..
Human   156 LGYSLGAHAAG-IAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHT--FTRGSP 217

  Fly   257 ER-------CGHADFYMNGGIMQPGCN-GQKINSFA------------CSHQRAPAYFLESI--- 298
            .|       .||.|.|.|||..||||| |:.|...|            |||:|:...|::|:   
Human   218 GRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNE 282

  Fly   299 RSPKGFWGWACSGYISYLLGMC 320
            .:|..  .:.||...::..|:|
Human   283 ENPSK--AYRCSSKEAFEKGLC 302

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG13282NP_609814.1 Pancreat_lipase_like 75..347 CDD:238363 85/281 (30%)
LPLNP_000228.1 Interaction with GPIHBP1. /evidence=ECO:0000269|PubMed:30559189 32..53 3/16 (19%)
lipo_lipase 33..473 CDD:132274 86/282 (30%)
Essential for determining substrate specificity. /evidence=ECO:0000269|PubMed:7592706 243..266 5/22 (23%)
Important for interaction with lipoprotein particles. /evidence=ECO:0000269|PubMed:27929370 417..421
Important for heparin binding. /evidence=ECO:0000269|PubMed:11342582 430..434
Interaction with GPIHBP1. /evidence=ECO:0000269|PubMed:26725083, ECO:0000269|PubMed:30559189 443..467
Blue background indicates that the domain is not in the aligned region.

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