DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13282 and LIPC

DIOPT Version :9

Sequence 1:	NP_001260521.1	Gene:	CG13282 / 35019	FlyBaseID:	FBgn0032612	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	XP_005254431.2	Gene:	LIPC / 3990	HGNCID:	6619	Length:	511	Species:	Homo sapiens

Alignment Length:	509	Identity:	123/509 - (24%)
Similarity:	206/509 - (40%)	Gaps:	100/509 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 FLNLKPIPIQHEDESSTEGSTNPTPTSTTTPSNRDITIGPCKWAI--GRSCPDPDVKYYIYTRHN 86
            ||.|||   |:..:....|.|..:......|.:.: ..|....|:  .::..:...::.::...|
Human    11 FLLLKP---QYHPQILITGVTTSSEDMRKAPVSEE-PFGRRAQAVETNKTLHEMKTRFLLFGETN 71

  Fly    87 PMDRQCLHIDESLEKSNLTDSYFNPRYPTKIIIHGYNSDMFL-------------HPLQQMREEY 138
            ...:..::..::|::..     ||...|..:||||::.|..|             .|.|.:
Human    72 QGCQIRINHPDTLQECG-----FNSSLPLVMIIHGWSVDGVLENWIWQMVAALKSQPAQPV---- 127

  Fly   139 LAKADYNIIYVDWSILSPGPCYISAVHNTKHAGTCTAQL---VERLVETGNTDIHVIGFSLGAQV 200
                  |:..|||..|:... |..||.||:..|...|.|   :|..|:...:.:|:||:||||.|
Human   128 ------NVGLVDWITLAHDH-YTIAVRNTRLVGKEVAALLRWLEESVQLSRSHVHLIGYSLGAHV 185

  Fly   201 PNYIARNL-SSFMLPRITGLDPAMPLFITSGKADKLDPSDASYVDVIHT-----NALVQGKMERC 259
            ..:...:: .:..:.||||||.|.|||..|..:::|.|.||::||.|||     ..|..|..:..
Human   186 SGFAGSSIGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDANFVDAIHTFTREHMGLSVGIKQPI 250

  Fly   260 GHADFYMNGGIMQPGCNGQKI-------------NSFACSHQRAPAYFLES-IRSPKGFWGWACS 310
            ||.|||.|||..||||:..::             .:..|||:|:...|::| :.:......:.|.
Human   251 GHYDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQTIKCSHERSVHLFIDSLLHAGTQSMAYPCG 315

  Fly   311 GYISYLLGMC-----PPTNFLLEAGENIRPTTRG----MFMIDTNDSSPFALGKW---------T 357
            ...|:..|:|     ...|.|   |.::|...|.    :|:: |...|||.:..:         |
Human   316 DMNSFSQGLCLSCKKGRCNTL---GYHVRQEPRSKSKRLFLV-TRAQSPFKVYHYQFKIQFINQT 376

  Fly   358 DLP--------TLGAKQPQWRVPTQKLKAPPNQGVDPLLHHID-QFGKLAA---NFNNLQMWPTE 410
            :.|        .||.|:...::|....|...:......|..:| ..|:|..   .:.|..:|...
Human   377 ETPIQTTFTMSLLGTKEKMQKIPITLGKGIASNKTYSFLITLDVDIGELIMIKFKWENSAVWANV 441

  Fly   411 QDPYEHWTSFSPEQKENDSDGDSV-----EEQDPVEFIEPDDRQMISTEARPTQ 459
            .|..:....:|...:.:.....::     |.|..:.|...:...::   .||||
Human   442 WDTVQTIIPWSTGPRHSGLVLKTIRVKAGETQQRMTFCSENTDDLL---LRPTQ 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13282	NP_001260521.1	Lipase	67..351	CDD:278576	89/330 (27%)
CG13282	NP_001260521.1	Pancreat_lipase_like	75..347	CDD:238363	87/316 (28%)
LIPC	XP_005254431.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28N19
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910