DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cse1 and CSE1

DIOPT Version :9

Sequence 1:	NP_523588.2	Gene:	Cse1 / 35016	FlyBaseID:	FBgn0022213	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_011276.1	Gene:	CSE1 / 852612	SGDID:	S000003207	Length:	960	Species:	Saccharomyces cerevisiae

Alignment Length:	986	Identity:	327/986 - (33%)
Similarity:	531/986 - (53%)	Gaps:	54/986 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ANLQLLAGYLQQTLSADPNVRRPAEKLLESTELQQNYPILLLNLIDKAQMDMTTRVAGAIAFKNY 70
            ::|:.:|.:|.:::.|  :..:.:|:.|...|.|..:.:.||::|....:.::||:|||:.|||:
Yeast     2 SDLETVAKFLAESVIA--STAKTSERNLRQLETQDGFGLTLLHVIASTNLPLSTRLAGALFFKNF 64

  Fly    71 IKRNWAAHLDSDGPDRIHESDRNTIKTLIVTLMLHSPVALQKQLSDAVSIIGKYDFPKKWPQLID 135
            |||.|   :|.:|...:..::...||..||.||:..|..||.|:.:|:|.|...|||.:||.|:.
Yeast    65 IKRKW---VDENGNHLLPANNVELIKKEIVPLMISLPNNLQVQIGEAISSIADSDFPDRWPTLLS 126

  Fly   136 EMVERFASGDFNVINGVLQTAHSLFKRYRYEFKSQALWEEIKFVLDRMAKPLTDLLQATMQLTKV 200
            ::..|.::.|.....|||..|||:|||:|..|:|..|:.|||.|||....|..:||:...:....
Yeast   127 DLASRLSNDDMVTNKGVLTVAHSIFKRWRPLFRSDELFLEIKLVLDVFTAPFLNLLKTVDEQITA 191

  Fly   201 HENNAGALKVIYGSLVLVNKVFFSLNSQDLPEFFEDNINTWMGAFIQQLAADVPSLRTADD-EDA 264
            :|||..:|.:::..|:::.|:::..|.||:||||||||...||.|.:.|:...|.|...|: |.|
Yeast   192 NENNKASLNILFDVLLVLIKLYYDFNCQDIPEFFEDNIQVGMGIFHKYLSYSNPLLEDPDETEHA 256

  Fly   265 GVLEHLRAQVCENICLYAKKYDEEFKPFMEQFVTAVWELLVKTSLHTKYDSLVSHALQFLSVVAD 329
            .||..:::.:.|.:.||..:|::.|.|.:.:|:...|.||...|...|||.|||.:|.||:.|..
Yeast   257 SVLIKVKSSIQELVQLYTTRYEDVFGPMINEFIQITWNLLTSISNQPKYDILVSKSLSFLTAVTR 321

  Fly   330 RQHYQSIFENPEILAQICDKVVIPNLDIRPSDEEIFEDSPEEYIRRDIEGSDIDTRRRAACDLVK 394
            ...|..||.|...:..|.:::::||:.:|..|.|:|||.|.||||||:||||.||||||..|.:|
Yeast   322 IPKYFEIFNNESAMNNITEQIILPNVTLREEDVELFEDDPIEYIRRDLEGSDTDTRRRACTDFLK 386

  Fly   395 TLSINFEQKIFGIFGQYLERLLTKYKENPATNWRSKDTAIYLVTSWASRGGTQKHGITQTSELVP 459
            .|....|..:..||..:::..:.:|..:|:.||:.||..|||.|:.|..|.....|::.|:.|:.
Yeast   387 ELKEKNEVLVTNIFLAHMKGFVDQYMSDPSKNWKFKDLYIYLFTALAINGNITNAGVSSTNNLLN 451

  Fly   460 LPEFCAQQIIPELERPNINEFPVLKAAAIKYVMVFRSILGPQVLASCLPQLIRHLPAESSVVHSY 524
            :.:|..::|.|:|...||... :|:..||||:..||:.|....|...:|.|...|..:..||::|
Yeast   452 VVDFFTKEIAPDLTSNNIPHI-ILRVDAIKYIYTFRNQLTKAQLIELMPILATFLQTDEYVVYTY 515

  Fly   525 AACSVEKILSMRDA--SNAIVFGPQILAPYTTELISGLFATLSLPGS-----GENEYVMKAIMRS 582
            ||.::||||::|::  |.|.:|..:.::..|..|:..|.|.:...||     .|||::|::|.|.
Yeast   516 AAITIEKILTIRESNTSPAFIFHKEDISNSTEILLKNLIALILKHGSSPEKLAENEFLMRSIFRV 580

  Fly   583 FSVLQSAAMPFMGVALPRLTEILTQVAKNPSRPQFNHYLFETLALCIKIVCHADSSAVSSFEEAL 647
            ....:.:..|.....|.:..||:|.:|||||.|:|.||.||::.   .|:.:.....:....:::
Yeast   581 LQTSEDSIQPLFPQLLAQFIEIVTIMAKNPSNPRFTHYTFESIG---AILNYTQRQNLPLLVDSM 642

  Fly   648 FPVFQGILQQDIVEFMPYVFQMLSVLLEMREGTGTIPEPYWALFPCLLSPALWDRTGNVTPLIRL 712
            .|.|..:..:||.||:|||||:::.::|.   :.||||....|...||:|.:|:..||:..:.||
Yeast   643 MPTFLTVFSEDIQEFIPYVFQIIAFVVEQ---SATIPESIKPLAQPLLAPNVWELKGNIPAVTRL 704

  Fly   713 ISAFIKQGSAQIQALGKLSGILGIFQKMIASKANDHEGFYLLQNLLSYYPPAEIQTNLRQIFGLL 777
            :.:|||..|:   ....|..:|||||::|||||.:..||.||::::.......::..::||..||
Yeast   705 LKSFIKTDSS---IFPDLVPVLGIFQRLIASKAYEVHGFDLLEHIMLLIDMNRLRPYIKQIAVLL 766

  Fly   778 FQRLSLSKTPKYLSGIIIFFSFYVIKFSGSQMAQLIDEIQPNLFGMLLDRVFITEMGKIPKEQDR 842
            .|||..|||.:|:..:.:||.....|.....:...|||:|..||..:.....||.:..|....||
Yeast   767 LQRLQNSKTERYVKKLTVFFGLISNKLGSDFLIHFIDEVQDGLFQQIWGNFIITTLPTIGNLLDR 831

  Fly   843 KMVAVGVTKLLTETPEILQQQYATFWPRLLHSLIDLFERPPEKLMGLEIGETAGVAE------DP 901
            |:..:||..::. ..:..|.:|.|.....::|:|             |...:..:|.      |.
Yeast   832 KIALIGVLNMVI-NGQFFQSKYPTLISSTMNSII-------------ETASSQSIANLKNDYVDL 882

  Fly   902 DAGYQVA-----FAQLTHAQPNQQDHLAEI---KDARQFLATSLSKFAQARAGEFSTLLSPLEPE 958
            |...:::     |::|........|.|.||   ...|.::|.:|:|: .|.:|  :|.|:.:.|:
Yeast   883 DNLEEISTFGSHFSKLVSISEKPFDPLPEIDVNNGVRLYVAEALNKY-NAISG--NTFLNTILPQ 944

  Fly   959 YKQVLQKYCDQ 969
            ..|..|...:|
Yeast   945 LTQENQVKLNQ 955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cse1	NP_523588.2	IBN_N	29..105	CDD:281761	27/75 (36%)
		Cse1	159..528	CDD:285678	139/369 (38%)
		CAS_CSE1	530..966	CDD:281384	135/456 (30%)
CSE1	NP_011276.1	CSE1	1..960	CDD:227944	327/986 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344703
Domainoid	1	1.000	259	1.000	Domainoid score	I313
eggNOG	1	0.900	-	-		E1_COG5657
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1006
Inparanoid	1	1.050	532	1.000	Inparanoid score	I184
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53855
OrthoFinder	1	1.000	-	-		FOG0004998
OrthoInspector	1	1.000	-	-		oto99233
orthoMCL	1	0.900	-	-		OOG6_101888
Panther	1	1.100	-	-	LDO	PTHR10997
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4827
SonicParanoid	1	1.000	-	-		X3532
TreeFam	1	0.960	-	-
	15	14.790