DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cse1 and Ipo11

DIOPT Version :9

Sequence 1:	NP_523588.2	Gene:	Cse1 / 35016	FlyBaseID:	FBgn0022213	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001347826.1	Gene:	Ipo11 / 76582	MGIID:	2442377	Length:	984	Species:	Mus musculus

Alignment Length:	1113	Identity:	217/1113 - (19%)
Similarity:	412/1113 - (37%)	Gaps:	280/1113 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEVTEANLQLLAGYLQQTLSADPNVRRPAEKLLESTELQQNYPILLLNLIDKAQMDMTTRVAGAI 65
            |::..|:..:|. .|.|..|.|..|.:|||:.|:..|.|..:..:|||:.....:|:..|....:
Mouse     1 MDLNSASSVVLQ-VLTQATSQDTAVLKPAEEQLKQWETQPGFYSVLLNIFTNHTLDINVRWLAVL 64

  Fly    66 AFKNYIKRNWAAHLDSDGPDRIHESDRNTIKTLIVTLMLHSPV-ALQKQLSDAVSIIGKYDFPKK 129
            .||:.|.|.|.    ...|..:.|.:::|::..::| ..:.|: .:..|::..::.:.:.|.|::
Mouse    65 YFKHGIDRYWR----RVAPHALSEEEKSTLRAGLIT-NFNEPINQIATQIAVLIAKVARLDCPRQ 124

  Fly   130 WPQLIDEMVERFASGD-----------FNVINGVLQTAHSLFKRYRYEFKSQ------ALWEEIK 177
            ||:||..:||.....|           ::|...:.....:..::..|:..|.      :||..
Mouse   125 WPELIPTLVESVKVQDDLRQHRALLTFYHVTKTLASKRLAADRKLFYDLASGIYNFACSLWNH-- 187

  Fly   178 FVLDRMAKPLTDLLQATMQLTKVHENNAGALKVIYGSLVLVNKVFFSLNSQDLPEFFEDNINTWM 242
                     .||..     |..|...|..|:.......:|..||   |....:..|.|.:.|..:
Mouse   188 ---------HTDTF-----LQHVSSGNEAAVLSSLERTLLSLKV---LRKLTVNGFVEPHKNMEV 235

  Fly   243 GAFIQQLAADVPSLRTADDEDAGVLEHL-------RAQVCENIC---------LYAK-------K 284
            ..|:.                 |:.|.|       |:...:|:|         |:.|       :
Mouse   236 MGFLH-----------------GIFERLKQFLECSRSIGTDNVCRDRLEKTIILFTKVLLDFLDQ 283

  Fly   285 YDEEFKPFMEQFVT-AVWELLVKTSLHTKYDSLVSHALQFLSVVADRQHYQ--SIFE--NPE--- 341
            :...|.|.:::.:. :|..:..:......::..:...:..:.::.....|:  ..||  :||
Mouse   284 HPISFTPLIQRSLEFSVSYVFTEVGEGVTFERFIVQCMNLIKMIVKNYAYKPSKNFEDSSPETLE 348

  Fly   342 ------------ILAQICDKVVIPNLDIRPSDEEIFEDSPEEYIRRDIEGSDIDTRRRAACDLVK 394
                        .|.:||.::|.....:...:..::|:.||.:   .:|.:..|:.:.:.....:
Mouse   349 AHKIKMAFFTYPTLTEICRRLVSHYFLLTEEELTMWEEDPEGF---TVEETGGDSWKYSLRPCTE 410

  Fly   395 TLSINFEQKIFGIFGQYLERLLTKYK---ENPATNWRS------KDTAIYLVTSWASRGGTQKHG 450
            .|.|:    ||..:.|.|..:|.:..   |.| ||...      || |:|.....|:
Mouse   411 VLFID----IFHEYNQTLTPVLLEMMQTLEGP-TNVEDMNALLIKD-AVYNAVGLAA-------- 461

  Fly   451 ITQTSELVPLPEFCAQQIIPELERPNINEFPVLKAAAI----KYVMV-FRSILGPQVLASCLPQL 510
             .:..:.|...::...|::|||:..: |.:..|:...|    :::.| |:|.|.|.     |.:.
Mouse   462 -FELFDSVDFDQWFKTQLLPELQVSH-NRYKPLRRRVIWLIGQWISVKFKSDLRPM-----LYEA 519

  Fly   511 IRHLPAESSVVHSYAACSVEKILSMRDASNAIVFGPQILAPYTTELISGLFATLSLPGSGENE-- 573
            |.:|..:..:|     ..:|...:::...:...|......||...:.:.||..|......:.:
Mouse   520 ICNLLQDQDLV-----VRIETATTLKLTVDDFEFRTDQFLPYLETMFTLLFQLLQQVTECDTKMH 579

  Fly   574 --YVMKAIMRSFSVLQSAAMPFMGVALPRLTEILTQVAKNPSRPQFNHYLFETLALCIKIV--CH 634
              :|:..::...:|   ...|::|..:..|..:..|      ..:.|......|...|.:|  ..
Mouse   580 VLHVLSCVIERVNV---QIRPYVGCLVQYLPLLWKQ------SEEHNMLRCAILTTLIHLVQGLG 635

  Fly   635 ADSSAVSSFEEALFPVFQGILQQDIVEFMPYVFQMLSVLLEMREGTGTIPEPYWAL----FPCLL 695
            |||..:..|   |.||.|  |..|:.: .|:|: :|...||:           |.:    .|| :
Mouse   636 ADSKNLYPF---LLPVIQ--LSTDVSQ-PPHVY-LLEDGLEL-----------WLVTLENSPC-V 681

  Fly   696 SPALWDRTGNVTPLIRLISAFI--KQGSAQIQALGKL-----------------SGILGIFQKMI 741
            :|.|.....|::||:.|.|:.:  :..|..::...|:                 :|:...|.:::
Mouse   682 TPELLRIFQNMSPLLELPSSCLANELSSENLRTCFKIINGYIFLSSTEFLQTYAAGLCQSFYELL 746

  Fly   742 -----------------ASKANDHEGFYLLQNLL----------SYYPPAEIQTNLRQIFGLLFQ 779
                             |.|.|...|..:.|.:|          ..||.      :..|:..:..
Mouse   747 PEITTEGQVQVLKVVENALKVNPVLGPQMFQRILPCVFRGVIEGERYPV------VMSIYLAVMG 805

  Fly   780 RLSLSKTPKYLSGIIIFFSFYVIKFSGSQMAQLIDEIQPNLFGMLLDRVFITEMGKIPKEQDRKM 844
            |:.|..|.        ||| .::...|.:..|.:|::..|:..|.:||     |..|.:.:.:|:
Mouse   806 RVLLQNTS--------FFS-SLLNEMGHEFNQEMDQLLGNVIEMWVDR-----MDNITQPERKKL 856

  Fly   845 VAVGVTKLLTETPEILQQQYATFWPRLLHSLIDLFERPPE-----KLMGLEIGETAGVAEDPDAG 904
            .|:.:..||.....::|.::.......:.:|.|:....||     ..|.:...|...|.||.:
Mouse   857 SALALLSLLPSDNSVIQDKFCGIINISVEALHDVMTEDPETRTYKDCMLMSQHEEPKVTEDEE-- 919

  Fly   905 YQVAFAQLTHAQPNQQD---HLAEIKD------ARQFLATSLSKFAQARAGE--FSTLLSPLEPE 958
                       .|.:||   .:..:||      .:||:...| |..|...||  |.:|:..::.|
Mouse   920 -----------PPTEQDKRKKMLALKDPVHTVSLQQFIYEKL-KAQQEILGEQGFQSLMETVDTE 972

  Fly   959 YKQVLQKY 966
            ....||::
Mouse   973 IVTQLQEF 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cse1	NP_523588.2	IBN_N	29..105	CDD:281761	19/75 (25%)
		Cse1	159..528	CDD:285678	76/431 (18%)
		CAS_CSE1	530..966	CDD:281384	101/507 (20%)
Ipo11	NP_001347826.1	Cse1	10..981	CDD:332697	215/1104 (19%)
		HEAT 1	123..160		8/36 (22%)
		HEAT 2	283..317		3/33 (9%)
		HEAT 3	318..356		5/37 (14%)
		HEAT 4	422..459		11/38 (29%)
		HEAT repeat	426..459	CDD:293787	9/34 (26%)
		HEAT 5	473..509		8/36 (22%)
		HEAT repeat	478..505	CDD:293787	6/27 (22%)
		HEAT 6	511..548		7/46 (15%)
		HEAT repeat	515..545	CDD:293787	5/39 (13%)
		HEAT repeat	552..586	CDD:293787	6/33 (18%)
		HEAT 7	555..593		6/37 (16%)
		HEAT repeat	599..630	CDD:293787	6/36 (17%)
		HEAT 8	600..636		7/41 (17%)
		HEAT 9	640..677		13/54 (24%)
		HEAT 11	740..782		7/41 (17%)
		HEAT 12	828..858		9/34 (26%)
		HEAT 13	859..896		5/36 (14%)
		HEAT 14	966..983		3/15 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5657
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810