Protein Alignment Cse1 and IPO11

DIOPT Version :9

• Sequence 1: NP_523588.2
• Gene: Cse1 / 35016
• FlyBaseID: FBgn0022213
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: NP_001128251.1
• Gene: IPO11 / 51194
• HGNCID: 20628
• Length: 1015
• Species: Homo sapiens
• Alignment Length: 1108
• Identity: 214/1108 - (19%)
• Similarity: 407/1108 - (36%)
• Gaps: 279/1108 - (25%)

  Fly     1 MEVTEANLQLLAGYLQQTLSADPNVRRPAEKLLESTELQQNYPILLLNLIDKAQMDMTTRVAGAI 65
            |::..|:..:|. .|.|..|.|..|.:|||:.|:..|.|..:..:|||:.....:|:..|....:
Human    41 MDLNSASTVVLQ-VLTQATSQDTAVLKPAEEQLKQWETQPGFYSVLLNIFTNHTLDINVRWLAVL 104

  Fly    66 AFKNYIKRNWAAHLDSDGPDRIHESDRNTIKTLIVTLMLHSPV-ALQKQLSDAVSIIGKYDFPKK 129
            .||:.|.|.|.    ...|..:.|.::.|::..::| ..:.|: .:..|::..::.:.:.|.|::
Human   105 YFKHGIDRYWR----RVAPHALSEEEKTTLRAGLIT-NFNEPINQIATQIAVLIAKVARLDCPRQ 164

  Fly   130 WPQLIDEMVERFASGD-----------FNVINGVLQTAHSLFKRYRYEFKSQ------ALWEEIK 177
            ||:||..::|.....|           ::|...:.....:..::..|:..|.      :||..
Human   165 WPELIPTLIESVKVQDDLRQHRALLTFYHVTKTLASKRLAADRKLFYDLASGIYNFACSLWNH-- 227

  Fly   178 FVLDRMAKPLTDLLQATMQLTKVHENNAGALKVIYGSLVLVNKVFFSLNSQDLPEFFEDNINTWM 242
                     .||..     |.:|...|..|:.......:|..||   |....:..|.|.:.|..:
Human   228 ---------HTDTF-----LQEVSSGNEAAILSSLERTLLSLKV---LRKLTVNGFVEPHKNMEV 275

  Fly   243 GAFIQQLAADVPSLRTADDEDAGVLEHL-------RAQVCENIC---------LYAK-------K 284
            ..|:.                 |:.|.|       |:...:|:|         |:.|       :
Human   276 MGFLH-----------------GIFERLKQFLECSRSIGTDNVCRDRLEKTIILFTKVLLDFLDQ 323

  Fly   285 YDEEFKPFMEQFVT-AVWELLVKTSLHTKYDSLVSHALQFLSVVADRQHYQ--SIFE--NPE--- 341
            :...|.|.:::.:. :|..:..:......::..:...:..:.::.....|:  ..||  :||
Human   324 HPFSFTPLIQRSLEFSVSYVFTEVGEGVTFERFIVQCMNLIKMIVKNYAYKPSKNFEDSSPETLE 388

  Fly   342 ------------ILAQICDKVVIPNLDIRPSDEEIFEDSPEEYIRRDIEGSDIDTRRRAACDLVK 394
                        .|.:||.::|.....:...:..::|:.||.:   .:|.:..|:.:.:.....:
Human   389 AHKIKMAFFTYPTLTEICRRLVSHYFLLTEEELTMWEEDPEGF---TVEETGGDSWKYSLRPCTE 450

  Fly   395 TLSINFEQKIFGIFGQYLERLLTKYKE--NPATNWRS------KDTAIYLVTSWASRGGTQKHGI 451
            .|.|:    ||..:.|.|..:|.:..:  ...||...      || |:|.....|:
Human   451 VLFID----IFHEYNQTLTPVLLEMMQTLQGPTNVEDMNALLIKD-AVYNAVGLAA--------- 501

  Fly   452 TQTSELVPLPEFCAQQIIPELERPNINEFPVLKAAAI----KYVMV-FRSILGPQVLASCLPQLI 511
            .:..:.|...::...|::|||:..: |.:..|:...|    :::.| |:|.|.|.     |.:.|
Human   502 YELFDSVDFDQWFKNQLLPELQVIH-NRYKPLRRRVIWLIGQWISVKFKSDLRPM-----LYEAI 560

  Fly   512 RHLPAESSVVHSYAACSVEKILSMRDASNAIVFGPQILAPYTTELISGLFATLSLPGSGENE-YV 575
            .:|..:..:|     ..:|...:::...:...|......||...:.:.||..|......:.: :|
Human   561 CNLLQDQDLV-----VRIETATTLKLTVDDFEFRTDQFLPYLETMFTLLFQLLQQVTECDTKMHV 620

  Fly   576 MKAIMRSFSVLQSAAMPFMGVALPRLTEILTQVAKNPSRPQFNHYLFETLALCIKIV--CHADSS 638
            :..:......:.....|::|..:..|..:..|      ..:.|......|...|.:|  ..|||.
Human   621 LHVLSCVIERVNMQIRPYVGCLVQYLPLLWKQ------SEEHNMLRCAILTTLIHLVQGLGADSK 679

  Fly   639 AVSSFEEALFPVFQGILQQDIVEFMPYVFQMLSVLLEMREGTGTIPEPYWAL----FPCL----- 694
            .:..|   |.||.|  |..|:.: .|:|: :|...||:           |.:    .||:
Human   680 NLYPF---LLPVIQ--LSTDVSQ-PPHVY-LLEDGLEL-----------WLVTLENSPCITPELL 726

  Fly   695 -----LSPALWDRTGNVTPLIRLISAFIKQGSA---QIQALGKLSGILGIFQKMI---------- 741
                 :||.|...:.|:....::|:.:|...|.   |..|:|.......:.:::.
Human   727 RIFQNMSPLLELSSENLRTCFKIINGYIFLSSTEFLQTYAVGLCQSFCELLKEITTEGQVQVLKV 791

  Fly   742 ---ASKANDHEGFYLLQNLLSY----------YPPAEIQTNLRQIFGLLFQRLSLSKTPKYLSGI 793
               |.|.|...|..:.|.:|.|          | |..:.|.|..:..:|.|..|
Human   792 VENALKVNPILGPQMFQPILPYVFKGIIEGERY-PVVMSTYLGVMGRVLLQNTS----------- 844

  Fly   794 IIFFSFYVIKFSGSQMA----QLIDEIQPNLFGMLLDRVFITEMGKIPKEQDRKMVAVGVTKLLT 854
              |||..:     ::||    |.:|::..|:..|.:||     |..|.:.:.||:.|:.:..||.
Human   845 --FFSSLL-----NEMAHKFNQEMDQLLGNMIEMWVDR-----MDNITQPERRKLSALALLSLLP 897

  Fly   855 ETPEILQQQYATFWPRLLHSLIDLFERPPEKLMGLEIGETAGVAEDPDAGYQVAFAQLTHAQ--- 916
            ....::|.::.......:..|.|:                  :.|||:.|.......::|.:
Human   898 SDNSVIQDKFCGIINISVEGLHDV------------------MTEDPETGTYKDCMLMSHLEEPK 944

  Fly   917 -------PNQQD---HLAEIKD------ARQFLATSLSKFAQARAGE--FSTLLSPLEPEYKQVL 963
                   |.:||   .:..:||      .:||:...| |..|...||  |.:|:..::.|....|
Human   945 VTEDEEPPTEQDKRKKMLALKDPVHTVSLQQFIYEKL-KAQQEMLGEQGFQSLMETVDTEIVTQL 1008

  Fly   964 QKY 966
            |::
Human  1009 QEF 1011

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cse1	NP_523588.2	IBN_N	29..105	CDD:281761	19/75 (25%)
		Cse1	159..528	CDD:285678	74/430 (17%)
		CAS_CSE1	530..966	CDD:281384	101/503 (20%)
IPO11	NP_001128251.1	CSE1	50..1012	CDD:227944	212/1099 (19%)
		IBN_N	68..140	CDD:281761	19/76 (25%)
		HEAT repeat	466..499	CDD:293787	7/33 (21%)
		HEAT repeat	518..545	CDD:293787	6/27 (22%)
		HEAT repeat	555..585	CDD:293787	5/39 (13%)
		HEAT repeat	592..626	CDD:293787	6/33 (18%)
		HEAT repeat	639..670	CDD:293787	6/36 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5657
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810