DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cse1 and Cse1l

DIOPT Version :9

Sequence 1:	NP_523588.2	Gene:	Cse1 / 35016	FlyBaseID:	FBgn0022213	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001102077.1	Gene:	Cse1l / 362273	RGDID:	1307536	Length:	971	Species:	Rattus norvegicus

Alignment Length:	983	Identity:	505/983 - (51%)
Similarity:	691/983 - (70%)	Gaps:	22/983 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEVTEANLQLLAGYLQQTLSADPNVRRPAEKLLESTELQQNYPILLLNLIDKAQMDMTTRVAGAI 65
            ||:::||||.|..||::||..||.:||||||.|||.|..||||:|||.|::|:| |...:|..::
  Rat     1 MELSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGNQNYPLLLLTLLEKSQ-DNVIKVCASV 64

  Fly    66 AFKNYIKRNWAAHLDSDGPDRIHESDRNTIKTLIVTLMLHSPVALQKQLSDAVSIIGKYDFPKKW 130
            .|||||||||  .:..|.|::|.|:||..||..||.|||.||..:|||||||:||:|:.|||:||
  Rat    65 TFKNYIKRNW--RIVEDEPNKICEADRVAIKANIVHLMLSSPEQIQKQLSDAISIVGREDFPQKW 127

  Fly   131 PQLIDEMVERFASGDFNVINGVLQTAHSLFKRYRYEFKSQALWEEIKFVLDRMAKPLTDLLQATM 195
            |.|:.|||.||.||||:||||||:||||||||||:||||..||.|||.|||..|.|||:|.:||:
  Rat   128 PDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRYRHEFKSNELWTEIKLVLDAFALPLTNLFKATI 192

  Fly   196 QLTKVHENNAGALKVIYGSLVLVNKVFFSLNSQDLPEFFEDNINTWMGAFIQQLAADVPSLRTAD 260
            :|...|.|:|.||::::.||:|::|:|:|||.||||||||||:.|||..|...|..|...|:|.|
  Rat   193 ELCSTHANDASALRILFSSLILISKLFYSLNFQDLPEFFEDNMETWMNNFHTLLTLDNKLLQTDD 257

  Fly   261 DEDAGVLEHLRAQVCENICLYAKKYDEEFKPFMEQFVTAVWELLVKTSLHTKYDSLVSHALQFLS 325
            :|:||:||.|::|:|:|..|||:||||||:.::.:||||:|.|||.|....|||.|||:|:|||:
  Rat   258 EEEAGLLELLKSQICDNAALYAQKYDEEFQRYLPRFVTAIWNLLVTTGQEVKYDLLVSNAIQFLA 322

  Fly   326 VVADRQHYQSIFENPEILAQICDKVVIPNLDIRPSDEEIFEDSPEEYIRRDIEGSDIDTRRRAAC 390
            .|.:|.||:::||:...|..||:||::||::.|.:|||.|||:.|||||||:|||||||||||||
  Rat   323 SVCERPHYKNLFEDQNTLTSICEKVIVPNMEFRAADEEAFEDNSEEYIRRDLEGSDIDTRRRAAC 387

  Fly   391 DLVKTLSINFEQKIFGIFGQYLERLLTKYKENPATNWRSKDTAIYLVTSWASRGGTQKHGITQTS 455
            |||:.|...||..:.|||..|:..:|.:|.:||:.||:.||.|||||||.||:..||||||||.:
  Rat   388 DLVRGLCKFFEGPVTGIFSGYVNSMLQEYAKNPSVNWKHKDAAIYLVTSLASKAQTQKHGITQAN 452

  Fly   456 ELVPLPEFCAQQIIPELERPNINEFPVLKAAAIKYVMVFRSILGPQVLASCLPQLIRHLPAESSV 520
            |||.|.||....|:|:|:..|:||||||||..|||:|:||:.:..:.|...:|.||.||.|||.|
  Rat   453 ELVNLTEFFVNHILPDLKSNNVNEFPVLKADGIKYIMIFRNQVPKEHLLVSIPLLISHLGAESIV 517

  Fly   521 VHSYAACSVEKILSMRDASNAIVFGPQILAPYTTELISGLFATLSLPGSGENEYVMKAIMRSFSV 585
            ||:|||.::|::.:||..:||.:|....:||:...|::.||..|:||||.||||:|||||||||:
  Rat   518 VHTYAAHALERLFTMRGPNNATLFTAAEIAPFVGILLTNLFKALTLPGSSENEYIMKAIMRSFSL 582

  Fly   586 LQSAAMPFMGVALPRLTEILTQVAKNPSRPQFNHYLFETLALCIKIVCHADSSAVSSFEEALFPV 650
            ||.|.:|::...:.:||:.|..|:||||:|.||||:||.:.|.|:|.|.|:.:||.:||||||.|
  Rat   583 LQEAIIPYIPTLITQLTQKLLAVSKNPSKPHFNHYMFEAICLSIRITCKANPAAVVNFEEALFLV 647

  Fly   651 FQGILQQDIVEFMPYVFQMLSVLLEMREGTGTIPEPYWALFPCLLSPALWDRTGNVTPLIRLISA 715
            |..|||.|:.||:|||||::|:|||..:  ..||..|.||||.||.|.||:|.||:..|:||:.|
  Rat   648 FTEILQNDVQEFIPYVFQVMSLLLETHK--NDIPSSYMALFPHLLQPVLWERAGNIPALVRLLQA 710

  Fly   716 FIKQGSAQI--QALGKLSGILGIFQKMIASKANDHEGFYLLQNLLSYYPPAEIQTNLRQIFGLLF 778
            |:::||:.|  .|..|:.|:||:|||:||||||||:|||||.:::.:.||..:....:|||.|||
  Rat   711 FLERGSSTIATAAADKIPGLLGVFQKLIASKANDHQGFYLLNSIIEHMPPESVDQYRKQIFILLF 775

  Fly   779 QRLSLSKTPKYLSGIIIFFSFYVIKFSGSQMAQLIDEIQPNLFGMLLDRVFITEMGKIPKEQDRK 843
            |||..|||.|::...::|.:.|.||:....:.::.|.|||.:|||:|:::.|.|:.|:....::|
  Rat   776 QRLQNSKTTKFIKSFLVFINLYCIKYGALALQEIFDGIQPKMFGMVLEKIIIPEIQKVSGNVEKK 840

  Fly   844 MVAVGVTKLLTETPEILQQQYATFWPRLLHSLIDLFERP-----PEKLMGLEIGETAGVAEDPDA 903
            :.|||:||||||.|.::..:|...|..||.|||.|||.|     |::...::|.:|        .
  Rat   841 ICAVGITKLLTECPAMMDTEYTKLWTPLLQSLIGLFELPEDDSIPDEEHFIDIEDT--------P 897

  Fly   904 GYQVAFAQLTHAQPNQQDHLAE-IKDARQFLATSLSKFAQARAGEFSTLLS-PLEPEYKQVLQKY 966
            |||.||:||..|...:.|.:.: :.:.|..||.:|.:.:.|..|...:::| .|..|..|.||.|
  Rat   898 GYQTAFSQLAFAGKKEYDPVGQTVNNPRVHLAQALHRLSTACPGRVPSMVSTSLNAEALQYLQGY 962

  Fly   967 CDQAGVRI 974
            ...|.|.:
  Rat   963 LQAASVTL 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cse1	NP_523588.2	IBN_N	29..105	CDD:281761	40/75 (53%)
		Cse1	159..528	CDD:285678	209/368 (57%)
		CAS_CSE1	530..966	CDD:281384	198/444 (45%)
Cse1l	NP_001102077.1	IBN_N	29..102	CDD:197981	40/75 (53%)
		Cse1	156..526	CDD:369909	209/369 (57%)
		CAS_CSE1	527..962	CDD:367469	198/444 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345358
Domainoid	1	1.000	432	1.000	Domainoid score	I565
eggNOG	1	0.900	-	-		E1_COG5657
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1006
Inparanoid	1	1.050	989	1.000	Inparanoid score	I291
OMA	1	1.010	-	-		QHG53855
OrthoDB	1	1.010	-	-		D1248958at2759
OrthoFinder	1	1.000	-	-		FOG0004998
OrthoInspector	1	1.000	-	-		oto96175
orthoMCL	1	0.900	-	-		OOG6_101888
Panther	1	1.100	-	-	LDO	PTHR10997
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3532
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770