DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cse1 and cse1l

DIOPT Version :9

Sequence 1:	NP_523588.2	Gene:	Cse1 / 35016	FlyBaseID:	FBgn0022213	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_958858.1	Gene:	cse1l / 30707	ZFINID:	ZDB-GENE-990603-1	Length:	971	Species:	Danio rerio

Alignment Length:	983	Identity:	510/983 - (51%)
Similarity:	692/983 - (70%)	Gaps:	22/983 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEVTEANLQLLAGYLQQTLSADPNVRRPAEKLLESTELQQNYPILLLNLIDKAQMDMTTRVAGAI 65
            ||:.:.|||.|..|||:||||||.|||||||.|||.|..||||||||.:::|:|.:: .||..|:
Zfish     1 MELNDGNLQTLTEYLQKTLSADPAVRRPAEKFLESVEGNQNYPILLLTVLEKSQNEV-IRVCSAV 64

  Fly    66 AFKNYIKRNWAAHLDSDGPDRIHESDRNTIKTLIVTLMLHSPVALQKQLSDAVSIIGKYDFPKKW 130
            .|||||||||  .:..|.|::|.:.||..||..||.|||.||..:|||||||:||||:.|||.||
Zfish    65 TFKNYIKRNW--RIVEDEPNKISDPDRTAIKANIVNLMLTSPEQIQKQLSDAISIIGREDFPLKW 127

  Fly   131 PQLIDEMVERFASGDFNVINGVLQTAHSLFKRYRYEFKSQALWEEIKFVLDRMAKPLTDLLQATM 195
            |.|:.|||.||.||||::|||||:||||||||||:||||..||.|||.|||..|:|||:|.:||:
Zfish   128 PDLLTEMVNRFQSGDFHIINGVLRTAHSLFKRYRHEFKSNELWSEIKLVLDTFAQPLTELFKATI 192

  Fly   196 QLTKVHENNAGALKVIYGSLVLVNKVFFSLNSQDLPEFFEDNINTWMGAFIQQLAADVPSLRTAD 260
            :|.:.|..:..||||::.||.|::|:|:|||.||||||||||:.|||..|...|..|...|:|.|
Zfish   193 ELCQTHATDINALKVLFSSLTLISKLFYSLNFQDLPEFFEDNMETWMTNFHNLLTLDNKLLQTDD 257

  Fly   261 DEDAGVLEHLRAQVCENICLYAKKYDEEFKPFMEQFVTAVWELLVKTSLHTKYDSLVSHALQFLS 325
            :|:||:||.|::|:|:|..|||:||||||:|::.:||||:|.|||.|....|||.|||:|:|||:
Zfish   258 EEEAGLLELLKSQICDNAALYAQKYDEEFQPYLPRFVTAIWNLLVTTGQEVKYDLLVSNAIQFLA 322

  Fly   326 VVADRQHYQSIFENPEILAQICDKVVIPNLDIRPSDEEIFEDSPEEYIRRDIEGSDIDTRRRAAC 390
            .|.:|.||:.:||:..:|..||:||::||::.|.:|||.|||:.||||.||:|||||||||||||
Zfish   323 SVCERPHYKHLFEDQNVLTSICEKVIVPNMEFRSADEEAFEDNSEEYIIRDLEGSDIDTRRRAAC 387

  Fly   391 DLVKTLSINFEQKIFGIFGQYLERLLTKYKENPATNWRSKDTAIYLVTSWASRGGTQKHGITQTS 455
            |||:.|...||..:.|||..|:..:|.:|.:||..||:.||.|||||||.||:..||||||||.:
Zfish   388 DLVRGLCKFFEGPVTGIFSGYVNSMLAEYAKNPGVNWKHKDAAIYLVTSLASKAQTQKHGITQAN 452

  Fly   456 ELVPLPEFCAQQIIPELERPNINEFPVLKAAAIKYVMVFRSILGPQVLASCLPQLIRHLPAESSV 520
            |||.|.||....|:.:|:.||:|||||||:.||||||.|||.|..:.|...:|.|:.||.|||.|
Zfish   453 ELVNLSEFFLNHILIDLKSPNVNEFPVLKSDAIKYVMTFRSQLPKEQLLQAVPLLVSHLQAESIV 517

  Fly   521 VHSYAACSVEKILSMRDASNAIVFGPQILAPYTTELISGLFATLSLPGSGENEYVMKAIMRSFSV 585
            .|:|||.::|::.:||..:|..:..|..:||:|.:|::.||..|::|||.||||:|||||||||:
Zfish   518 QHTYAAHALERLFTMRGGNNTTLITPTEMAPFTEQLLNHLFKALAIPGSSENEYIMKAIMRSFSL 582

  Fly   586 LQSAAMPFMGVALPRLTEILTQVAKNPSRPQFNHYLFETLALCIKIVCHADSSAVSSFEEALFPV 650
            ||.|.:|::...:.:||..|..|:||||:|.|||||||:|.|.|:|.|.|:...|||||||||||
Zfish   583 LQEAIVPYIPTLIGQLTHKLLLVSKNPSKPHFNHYLFESLCLSIRITCKANPDTVSSFEEALFPV 647

  Fly   651 FQGILQQDIVEFMPYVFQMLSVLLEMREGTGTIPEPYWALFPCLLSPALWDRTGNVTPLIRLISA 715
            |..|||.|:.||:|||||::|:|||:.  :.:||..|.||||.||.|.||:||||:.||:||:.|
Zfish   648 FTEILQNDVQEFVPYVFQVMSLLLEIH--SNSIPSSYMALFPHLLQPVLWERTGNIPPLVRLLQA 710

  Fly   716 FIKQGSAQI--QALGKLSGILGIFQKMIASKANDHEGFYLLQNLLSYYPPAEIQTNLRQIFGLLF 778
            ::::|:|.|  .|..|:.|:||:|||:||||||||:|||||.:::.:.|...|....:|||.|||
Zfish   711 YLEKGAAAIANTASDKIPGLLGVFQKLIASKANDHQGFYLLNSIVEHMPAEAITQYRKQIFILLF 775

  Fly   779 QRLSLSKTPKYLSGIIIFFSFYVIKFSGSQMAQLIDEIQPNLFGMLLDRVFITEMGKIPKEQDRK 843
            |||..|||.|::...::|.:.|.:|:....:.::.|:|||.:|||:::::.|.|:.|:..:.::|
Zfish   776 QRLQSSKTTKFVKSFLVFINLYSVKYGAIALQEIFDDIQPKMFGMVVEKIVIPEVQKVSGQVEKK 840

  Fly   844 MVAVGVTKLLTETPEILQQQYATFWPRLLHSLIDLFERP-----PEKLMGLEIGETAGVAEDPDA 903
            :.|||:.|:|||.|.::..:|...|..||.:||.|||.|     |:....::|.:|        .
Zfish   841 ICAVGIIKILTECPAMMDTEYTKLWAPLLQALIGLFELPEDDSIPDDEHFIDIEDT--------P 897

  Fly   904 GYQVAFAQLTHAQPNQQDHLAE-IKDARQFLATSLSKFAQARAGEFSTLLS-PLEPEYKQVLQKY 966
            |||.||:||..|...:.|.:.: :.:.:..||.||.|.:.|..|...::|| .|..|..|.||.|
Zfish   898 GYQTAFSQLAFAGKKEHDPIGDAVSNPKILLAQSLHKLSTACPGRVPSMLSTSLPTEALQFLQGY 962

  Fly   967 CDQAGVRI 974
            ...|.|::
Zfish   963 LQAATVQL 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cse1	NP_523588.2	IBN_N	29..105	CDD:281761	40/75 (53%)
		Cse1	159..528	CDD:285678	210/368 (57%)
		CAS_CSE1	530..966	CDD:281384	199/444 (45%)
cse1l	NP_958858.1	IBN_N	29..102	CDD:197981	40/75 (53%)
		Cse1	156..525	CDD:285678	210/368 (57%)
		CAS_CSE1	527..962	CDD:281384	199/444 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586403
Domainoid	1	1.000	430	1.000	Domainoid score	I571
eggNOG	1	0.900	-	-		E1_COG5657
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1006
Inparanoid	1	1.050	998	1.000	Inparanoid score	I290
OMA	1	1.010	-	-		QHG53855
OrthoDB	1	1.010	-	-		D1248958at2759
OrthoFinder	1	1.000	-	-		FOG0004998
OrthoInspector	1	1.000	-	-		oto40878
orthoMCL	1	0.900	-	-		OOG6_101888
Panther	1	1.100	-	-	LDO	PTHR10997
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4827
SonicParanoid	1	1.000	-	-		X3532
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800