DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cse1 and kap114

DIOPT Version :9

Sequence 1:	NP_523588.2	Gene:	Cse1 / 35016	FlyBaseID:	FBgn0022213	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_593739.2	Gene:	kap114 / 2541885	PomBaseID:	SPAC22H10.03c	Length:	993	Species:	Schizosaccharomyces pombe

Alignment Length:	929	Identity:	184/929 - (19%)
Similarity:	348/929 - (37%)	Gaps:	189/929 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LQQTLSADPNVRRPAEKLLESTELQQNYPILLLNLIDKAQMDMTTRVAGAIAFKNYIKRNWAAHL 79
            |:|..|||||.|..||..|...|...::...|.: |..:...:..|....|..:.||..:|:...
pombe    10 LEQVQSADPNSRIQAELGLRDLEKYHDFAAKLTD-IASSGASVPLRQGSLIYLQRYIVHHWSPLF 73

  Fly    80 D--SDGP---DRIHESDRNTIKTLIVTLMLHSPVALQKQLSDAVSIIGKYDFPKKWPQLIDEMVE 139
            :  .|||   :.:.:..|.|:..|:|:|   ....|.|.::.|||:|...|:|.:||:::..::.
pombe    74 EQFQDGPIPDENVKKHVRETLLHLLVSL---DNFTLIKAVAYAVSLIANVDYPDEWPEVVPAVLH 135

  Fly   140 RFASGDFNVINGVLQTAHSLFKRYRYEFKSQALWEEIKFVL-DRMAKPLTDLLQATMQLTKVHEN 203
            ...|.:.|.||..|....        |...::|.||..|:: .::|..|...:.:......:...
pombe   136 LLQSTNENSINASLDVLD--------ELVDESLVEEQFFIIAPQLASILYQFIFSAPPNDSMRML 192

  Fly   204 NAGALKVIYGSLVLVNKVFFSLNSQDLPEFFEDNINTWMGAFIQQLAADVPSLRTADDEDAGVLE 268
            .|..:|:....|.|: :::....::.:..|.|..:..||..|..:....:     .||...
pombe   193 QARGIKLFRSCLELI-EIYKETKAEHVRVFLEQILPPWMDMFSHKFEVSL-----VDDRQV---- 247

  Fly   269 HLRAQVCENICLYA----------KKYDEEFKPFMEQFVTAVWELLVK----------------- 306
             :....|...|:..          :.:..:..|::..||..||.::.|
pombe   248 -ILPDSCGYFCIMGEIAMTLTKLRELFPSKLTPYVVTFVELVWNIIEKLLDPYIREVVFSDGLDD 311

  Fly   307 TSLHTKYD-SLVSHALQFLSVVADRQHYQSIFEN--------PEILAQICDKVVIPNLDIRPSDE 362
            ::...||. ..:...|.|:||....:..|::|.:        |..:..:.....:|...|
pombe   312 SAFGDKYPIRYLVELLLFVSVALQSKFVQNLFVSNTVPVPPLPPCIPLLVQYTQLPKHQI----- 371

  Fly   363 EIFEDSPEEYIRRDIEGSDI--DTRRRAACDLVKTLSINFEQKIFGIFGQYLERLLTKYKENPAT 425
            |::|....|||..:. ..|.  ||.|.||..::..    ||:.......|.|..:...|..|...
pombe   372 EVYESDVSEYIANEF-SMDFASDTVRGAAISVLSA----FEEHTTLPIQQSLREMSATYILNNEI 431

  Fly   426 NWRSKDTAIYLVTSWASRGGTQKHGITQTSELVPLPEFCAQQIIPELERPNINEFPVLKAAAIKY 490
            ||..::..:|...|..:....     |....|.|:.|....:|       :.::.|:|..:....
pombe   432 NWIYQEALLYACCSVDAASDD-----TYDDYLDPIYEAIKVRI-------DYSDAPILLLSRFFL 484

  Fly   491 VMVFRS---ILGPQVLASCLPQLIRHLPAESSVVHSYAA-------CSVEKILSMRDASNAIVFG 545
            .:.:.|   ::..|.....:..|:..|..::.   .|||       |||.|:..:......|:
pombe   485 FIGYFSESTVVASQFFQIIMNNLVNALQVDTV---QYAAMKAIERFCSVGKVKPILSLQPMIL-- 544

  Fly   546 PQILAPYTTELISGLFATLSLPGSGENEYVM--KAIMRSFSVLQSAAMPFMGVALPRLTEILTQV 608
             ::|:.|.::             |.:...|:  :||..:..:..:.|.......:|.|..:   |
pombe   545 -EVLSQYASK-------------SSDEALVLLVEAISSAVKLDCAKAAELGNSVIPLLFNL---V 592

  Fly   609 AKNPSRPQFNHYLFETLALCIKIVCHADSSAVSSFEEALFPVFQGILQQDIVEFMPYVFQMLSVL 673
            |.|.|.|    |:...:....:.:.||.::..|..|..|..:.|.:.|:|     |.:..:.:.|
pombe   593 ATNASDP----YICGIIEDTFEDIIHAANNYESMCEITLPELLQVLNQED-----PIMVNIGATL 648

  Fly   674 LE--MREGTGTIPEPYWALFPCLLSPALWDRTGNVTPLIRLISAFIKQGSAQIQALG-------- 728
            |.  :|.|...:|..:               .|.|.|.:..|:. |..|..::..|.
pombe   649 LSCLIRAGPSPLPNGF---------------VGYVLPPVYKITQ-IHSGDTELLQLSQEILKGLL 697

  Fly   729 ----------KLSG------ILGIFQKMIASKANDHEGFYLLQNLLSYYPPAEIQTNLRQIFGLL 777
                      ::||      ||.|..:::..:::|...|.:...||.....|....:|:.|....
pombe   698 EKDTPQLLETEISGSSGFQYILFILHQLLDKESDDSACFLVGPILLELADHASQMVDLQSILLSC 762

  Fly   778 FQRLSLSKTPKYLSGIIIFFSFYVIKFSGSQM----AQLIDEIQPNLFGMLL-----DRVFITEM 833
            .:||::::.|:::..||..|:..::|.|...|    :.|::|.....|.:|:     :.|:.:..
pombe   763 IKRLAIAEQPRFIQSIIYVFAKLIVKDSLGMMHFLTSSLLNEQGLTAFEVLMTVWCDNFVYFSNF 827

  Fly   834 GKIPKEQDRKMVAVGVTKL 852
            ..|      .::.:.:||:
pombe   828 KNI------SIICIAMTKI 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cse1	NP_523588.2	IBN_N	29..105	CDD:281761	19/80 (24%)
		Cse1	159..528	CDD:285678	72/417 (17%)
		CAS_CSE1	530..966	CDD:281384	67/360 (19%)
kap114	NP_593739.2	CSE1	1..993	CDD:227944	184/929 (20%)
kap114	NP_593739.2	IBN_N	24..100	CDD:281761	17/76 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5657
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810