DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cse1 and xpo-2

DIOPT Version :9

Sequence 1:	NP_523588.2	Gene:	Cse1 / 35016	FlyBaseID:	FBgn0022213	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_490716.1	Gene:	xpo-2 / 171621	WormBaseID:	WBGene00002079	Length:	938	Species:	Caenorhabditis elegans

Alignment Length:	993	Identity:	289/993 - (29%)
Similarity:	507/993 - (51%)	Gaps:	90/993 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LQLLAGYLQQTLSADPNVRRPAEKLLESTELQQNYPILLLNLI--DKAQMDMTTRVAGAIAFKNY 70
            ::.:...|||||..|..:|:..|:.|.|.:....|.|.:|.|:  ::.|:....|:|.|:|.||:
Worm     1 MEQIGAALQQTLEPDAAIRKRGEEALRSLQSNPGYIIQILQLVVNEQQQIAPQIRIAAAVALKNF 65

  Fly    71 IKRNWAAHLDSDGPD---RIHESDRNTIKTLIVTLMLHSPVALQKQLSDAVSIIGKYDFPKKWPQ 132
            :||||       ||.   .:.:.|....:::::..|.::...:|:.||:|:.:|.:.|||:|||.
Worm    66 VKRNW-------GPAPEVEMGQEDEEQFRSMLLEAMFNTKSNVQEILSNALYLIAQRDFPEKWPD 123

  Fly   133 LIDEMVERFASGDFNVINGVLQTAHSLFKRYRYEFKSQALWEEIKFVLDRMAKPLTDLLQATMQL 197
            |:..:.:.....|.|.:...|.:...:|:::|:|.||..||:|:|..|....:|||.||:..|::
Worm   124 LVPYLSKFLNGADLNHLVASLASMEQIFRKFRFESKSAELWKELKKCLLSTQEPLTLLLRNMMEV 188

  Fly   198 TKVHENNAGA------LKVIYGSLVLVNKVFFSLNSQDLPEFFEDNINTWMGAFIQQLAADVPSL 256
            .: .::..||      |:|    |:|:.||:.||.||::||:|||::..||..|:..:..|.|:
Worm   189 GQ-RKDQLGADEIAQWLRV----LLLIAKVYHSLCSQEIPEYFEDHLKDWMPHFLHLVQIDAPT- 247

  Fly   257 RTADDEDAGVLEHLRAQVCENICLYAKKYDEEFKPFMEQFVTAVWELLVKTSLHTKYDSLVSHAL 321
            :|::..:...|:.|:.::||...||:::|:||...|:...:.|||.||..|...|:||::|..||
Worm   248 QTSNSGEPTTLDELKHEICEIFTLYSQRYEEEISEFVPDIILAVWNLLKSTGPDTRYDTMVCAAL 312

  Fly   322 QFLSVVADRQHYQSIFENPEILAQICDKVVIPNLDIRPSDEEIFEDSPEEYIRRDIEGSDIDTRR 386
            :|||:|:.||:|:..|....:|..:.:.|.:.||.:|..|.|:|||.|.:|::|||||:|:.|||
Worm   313 EFLSMVSQRQYYEGHFTGEGVLKTLAENVCVQNLLLRQQDMELFEDEPLDYMKRDIEGTDVGTRR 377

  Fly   387 RAACDLVKTLSINFEQKIFGIFGQYLERLLTKYKENPATNWRSKDTAIYLVTSWASRGGTQKHGI 451
            |.|.||.:.|...||.::....|:.::.||      .:.:|...|....|:|:.|.:..|.|.|:
Worm   378 RGAIDLARGLCRRFEAQMLPCLGEIVQNLL------GSGDWIKIDIVYSLITAIAVKTETAKSGV 436

  Fly   452 TQTSELVPLPEFCAQQIIPELERPNINEFPVLKAAAIKYVMVFRSILGPQVLASCLPQLIRHLPA 516
            |.|:.||.:.:|...|:...| ..::|:.|:|||.|:|:.:.||..|.|:.|.:.:......|.:
Worm   437 TATNPLVDINDFFITQVATHL-NADVNQTPILKADALKFAVTFRKQLAPEHLMTAIKSADALLSS 500

  Fly   517 ESSVVHSYAACSVEKILSMRDASNAIVFGPQILAPYTTELISGLFATLSLPGSGENE-YVMKAIM 580
            .:.::|.|||.::|||| :.|::.  :|..|.|.  .:.::..|..........:|. |::|||:
Worm   501 NTPILHKYAAYAIEKIL-LADSNK--IFSAQNLP--VSSILQNLVTAFDKDAKAQNSPYLIKAIL 560

  Fly   581 RSFSVLQSAAMPFMGVALPRLTEILTQVAKNPSRPQFNHYLFETLALCIKIVCHADSSAVSSFEE 645
            |...:|....:........:|.:::....|||:.....|:||||  :|:.|.  ...:..:|.:.
Worm   561 RIIVILDDDTIRHADAIAVKLAQLVESATKNPADSVHTHFLFET--ICVLIT--KTRTIGASLDA 621

  Fly   646 ALFPVFQGILQQDIVEFMPYVFQMLSVLLEMREGTGTIPEPYWALFPCLLSPALWDRTGNVTPLI 710
            .|.|:.:.|.::|:.:.:||..|:..||:.......:..:.:....|.|||..||.|:.||...:
Worm   622 QLLPLIEVIFREDLEDLIPYALQITGVLVSSCIARNSSIDQFSPFLPFLLSERLWARSANVPAAL 686

  Fly   711 RLISAFIKQGSAQIQALGKLSG-ILGIFQKMIASKANDHEGFYLLQNLLSYYPPAEIQTNLRQIF 774
            .::...:...:.::  :.:.|| ||....:::.||..|..||.|...:|   |..|........|
Worm   687 SVLEVILSVNAQRV--VSENSGLILSHLARLLGSKTLDQYGFQLAATIL---PSIEHFEGSAMTF 746

  Fly   775 GL--LFQRLSLSKTPKYLSGIIIFFSFYVIKFSGSQMAQLIDEIQPNLFGMLLDRVFITEMGKIP 837
            .|  :|:|:..|||||::...|:|...:.|..|...:.|..:.||..:||||:::|...::..:.
Worm   747 VLNTMFRRVQSSKTPKFMKLFIVFLCRFTIARSAQDLVQSCENIQTGMFGMLIEKVVCIDLPGLK 811

  Fly   838 KE---QDRKMVAVGVTKLLTETPEILQQQYATFWPRLLHSLIDLFE----------RPPEKLMGL 889
            :.   .:::::|:|:..||.:..:.|..||..    |.:.:..|.|          .|.|:...:
Worm   812 QTTTGPEKRIIAIGMGNLLADVTQQLVGQYGI----LSYEVAMLLEAASASDRAVLSPEEEQASM 872

  Fly   890 EIGETAGVAEDPDAGYQVAFAQLTHAQPNQQDHLAEIKDARQFLATSLSKFAQA----RAGEFST 950
            ...|  |...:|       |.:|::| |.|....|.|.:.:.:       ||||    ..|....
Worm   873 YNAE--GEFVNP-------FCRLSYA-PKQPPVAANIANHKAY-------FAQAVLVRGPGNCPE 920

  Fly   951 LLSPLEPE---YKQVLQK 965
            .|..:.||   |.|.:|:
Worm   921 TLRSVPPEIVTYLQSIQQ 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cse1	NP_523588.2	IBN_N	29..105	CDD:281761	22/80 (28%)
		Cse1	159..528	CDD:285678	132/374 (35%)
		CAS_CSE1	530..966	CDD:281384	113/460 (25%)
xpo-2	NP_490716.1	CSE1	3..799	CDD:227944	254/829 (31%)
xpo-2	NP_490716.1	Cse1	150..513	CDD:369909	132/375 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162203
Domainoid	1	1.000	241	1.000	Domainoid score	I1256
eggNOG	1	0.900	-	-		E1_COG5657
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	425	1.000	Inparanoid score	I977
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53855
OrthoDB	1	1.010	-	-		D1248958at2759
OrthoFinder	1	1.000	-	-		FOG0004998
OrthoInspector	1	1.000	-	-		oto17964
orthoMCL	1	0.900	-	-		OOG6_101888
Panther	1	1.100	-	-	LDO	PTHR10997
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4827
SonicParanoid	1	1.000	-	-		X3532
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800