DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cse1 and CSE1L

DIOPT Version :9

Sequence 1:	NP_523588.2	Gene:	Cse1 / 35016	FlyBaseID:	FBgn0022213	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001307.2	Gene:	CSE1L / 1434	HGNCID:	2431	Length:	971	Species:	Homo sapiens

Alignment Length:	983	Identity:	508/983 - (51%)
Similarity:	691/983 - (70%)	Gaps:	22/983 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEVTEANLQLLAGYLQQTLSADPNVRRPAEKLLESTELQQNYPILLLNLIDKAQMDMTTRVAGAI 65
            ||:::||||.|..||::||..||.:||||||.|||.|..||||:|||.|::|:| |...:|..::
Human     1 MELSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGNQNYPLLLLTLLEKSQ-DNVIKVCASV 64

  Fly    66 AFKNYIKRNWAAHLDSDGPDRIHESDRNTIKTLIVTLMLHSPVALQKQLSDAVSIIGKYDFPKKW 130
            .|||||||||  .:..|.|::|.|:||..||..||.|||.||..:|||||||:||||:.|||:||
Human    65 TFKNYIKRNW--RIVEDEPNKICEADRVAIKANIVHLMLSSPEQIQKQLSDAISIIGREDFPQKW 127

  Fly   131 PQLIDEMVERFASGDFNVINGVLQTAHSLFKRYRYEFKSQALWEEIKFVLDRMAKPLTDLLQATM 195
            |.|:.|||.||.||||:||||||:||||||||||:||||..||.|||.|||..|.|||:|.:||:
Human   128 PDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRYRHEFKSNELWTEIKLVLDAFALPLTNLFKATI 192

  Fly   196 QLTKVHENNAGALKVIYGSLVLVNKVFFSLNSQDLPEFFEDNINTWMGAFIQQLAADVPSLRTAD 260
            :|...|.|:|.||::::.||:|::|:|:|||.||||||||||:.|||..|...|..|...|:|.|
Human   193 ELCSTHANDASALRILFSSLILISKLFYSLNFQDLPEFFEDNMETWMNNFHTLLTLDNKLLQTDD 257

  Fly   261 DEDAGVLEHLRAQVCENICLYAKKYDEEFKPFMEQFVTAVWELLVKTSLHTKYDSLVSHALQFLS 325
            :|:||:||.|::|:|:|..|||:||||||:.::.:||||:|.|||.|....|||.|||:|:|||:
Human   258 EEEAGLLELLKSQICDNAALYAQKYDEEFQRYLPRFVTAIWNLLVTTGQEVKYDLLVSNAIQFLA 322

  Fly   326 VVADRQHYQSIFENPEILAQICDKVVIPNLDIRPSDEEIFEDSPEEYIRRDIEGSDIDTRRRAAC 390
            .|.:|.||:::||:...|..||:||::||::.|.:|||.|||:.|||||||:|||||||||||||
Human   323 SVCERPHYKNLFEDQNTLTSICEKVIVPNMEFRAADEEAFEDNSEEYIRRDLEGSDIDTRRRAAC 387

  Fly   391 DLVKTLSINFEQKIFGIFGQYLERLLTKYKENPATNWRSKDTAIYLVTSWASRGGTQKHGITQTS 455
            |||:.|...||..:.|||..|:..:|.:|.:||:.||:.||.|||||||.||:..||||||||.:
Human   388 DLVRGLCKFFEGPVTGIFSGYVNSMLQEYAKNPSVNWKHKDAAIYLVTSLASKAQTQKHGITQAN 452

  Fly   456 ELVPLPEFCAQQIIPELERPNINEFPVLKAAAIKYVMVFRSILGPQVLASCLPQLIRHLPAESSV 520
            |||.|.||....|:|:|:..|:||||||||..|||:|:||:.:..:.|...:|.||.||.|||.|
Human   453 ELVNLTEFFVNHILPDLKSANVNEFPVLKADGIKYIMIFRNQVPKEHLLVSIPLLINHLQAESIV 517

  Fly   521 VHSYAACSVEKILSMRDASNAIVFGPQILAPYTTELISGLFATLSLPGSGENEYVMKAIMRSFSV 585
            ||:|||.::|::.:||..:||.:|....:||:...|::.||..|:||||.||||:|||||||||:
Human   518 VHTYAAHALERLFTMRGPNNATLFTAAEIAPFVEILLTNLFKALTLPGSSENEYIMKAIMRSFSL 582

  Fly   586 LQSAAMPFMGVALPRLTEILTQVAKNPSRPQFNHYLFETLALCIKIVCHADSSAVSSFEEALFPV 650
            ||.|.:|::...:.:||:.|..|:||||:|.||||:||.:.|.|:|.|.|:.:||.:||||||.|
Human   583 LQEAIIPYIPTLITQLTQKLLAVSKNPSKPHFNHYMFEAICLSIRITCKANPAAVVNFEEALFLV 647

  Fly   651 FQGILQQDIVEFMPYVFQMLSVLLEMREGTGTIPEPYWALFPCLLSPALWDRTGNVTPLIRLISA 715
            |..|||.|:.||:|||||::|:|||..:  ..||..|.||||.||.|.||:||||:..|:||:.|
Human   648 FTEILQNDVQEFIPYVFQVMSLLLETHK--NDIPSSYMALFPHLLQPVLWERTGNIPALVRLLQA 710

  Fly   716 FIKQGSAQI--QALGKLSGILGIFQKMIASKANDHEGFYLLQNLLSYYPPAEIQTNLRQIFGLLF 778
            |:::||..|  .|..|:.|:||:|||:||||||||:|||||.:::.:.||..:....:|||.|||
Human   711 FLERGSNTIASAAADKIPGLLGVFQKLIASKANDHQGFYLLNSIIEHMPPESVDQYRKQIFILLF 775

  Fly   779 QRLSLSKTPKYLSGIIIFFSFYVIKFSGSQMAQLIDEIQPNLFGMLLDRVFITEMGKIPKEQDRK 843
            |||..|||.|::...::|.:.|.||:....:.::.|.|||.:|||:|:::.|.|:.|:....::|
Human   776 QRLQNSKTTKFIKSFLVFINLYCIKYGALALQEIFDGIQPKMFGMVLEKIIIPEIQKVSGNVEKK 840

  Fly   844 MVAVGVTKLLTETPEILQQQYATFWPRLLHSLIDLFERP-----PEKLMGLEIGETAGVAEDPDA 903
            :.|||:||||||.|.::..:|...|..||.|||.|||.|     |::...::|.:|        .
Human   841 ICAVGITKLLTECPPMMDTEYTKLWTPLLQSLIGLFELPEDDTIPDEEHFIDIEDT--------P 897

  Fly   904 GYQVAFAQLTHAQPNQQDHLAE-IKDARQFLATSLSKFAQARAGEFSTLLS-PLEPEYKQVLQKY 966
            |||.||:||..|...:.|.:.: :.:.:..||.||.|.:.|..|...:::| .|..|..|.||.|
Human   898 GYQTAFSQLAFAGKKEHDPVGQMVNNPKIHLAQSLHKLSTACPGRVPSMVSTSLNAEALQYLQGY 962

  Fly   967 CDQAGVRI 974
            ...|.|.:
Human   963 LQAASVTL 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cse1	NP_523588.2	IBN_N	29..105	CDD:281761	40/75 (53%)
		Cse1	159..528	CDD:285678	209/368 (57%)
		CAS_CSE1	530..966	CDD:281384	200/444 (45%)
CSE1L	NP_001307.2	IBN_N	29..102	CDD:197981	40/75 (53%)
		Cse1	156..526	CDD:369909	209/369 (57%)
		CAS_CSE1	527..962	CDD:367469	200/444 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151841
Domainoid	1	1.000	432	1.000	Domainoid score	I588
eggNOG	1	0.900	-	-		E1_COG5657
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1006
Inparanoid	1	1.050	992	1.000	Inparanoid score	I306
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53855
OrthoDB	1	1.010	-	-		D1248958at2759
OrthoFinder	1	1.000	-	-		FOG0004998
OrthoInspector	1	1.000	-	-		oto89047
orthoMCL	1	0.900	-	-		OOG6_101888
Panther	1	1.100	-	-	LDO	PTHR10997
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4827
SonicParanoid	1	1.000	-	-		X3532
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800