DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cse1 and AgaP_AGAP002970

DIOPT Version :9

Sequence 1:	NP_523588.2	Gene:	Cse1 / 35016	FlyBaseID:	FBgn0022213	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	XP_311926.5	Gene:	AgaP_AGAP002970 / 1272993	VectorBaseID:	AGAP002970	Length:	1019	Species:	Anopheles gambiae

Alignment Length:	1005	Identity:	200/1005 - (19%)
Similarity:	374/1005 - (37%)	Gaps:	244/1005 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LQQTLSADPNVRRPAEKLLESTELQQNYPILLLNLIDKAQMDMTTRVAGAIAFKNYIKRNWAAHL 79
            ||...|.|..:.:|||:.|...|:|..:.:.|:.:.....:|...|...::.|||.:.:.|.|
Mosquito    11 LQYACSQDTQMLKPAEQKLAEWEVQPGFHLTLVKIFSNQSLDAGVRWMASLYFKNGVLKYWRA-- 73

  Fly    80 DSDGPDRIHESDRNTIKTLIVTLMLHSPV-ALQKQLSDAVSIIGKYDFPKKWPQLIDEMVERFAS 143
              ...:.|...::..||.|:: :....|| .:..|::..:..|.:::....|.:||..:|:...|
Mosquito    74 --SAQNAILREEKLEIKKLLL-MKFDEPVQQIAVQIAVLIGNINRHECLNDWKELIPTIVKAVQS 135

  Fly   144 GDFNVIN-GVLQTAHSL-------FKRYRYEFKSQAL-WEEIKFVLDRMAKPLTDLLQATMQL-- 197
            .|..|.: |::...|.:       ..|.|.:|:|.|| |.:  |||        :|.:...||
Mosquito   136 DDMLVQHRGLMVMLHVVKVLCSKRIPRDRQQFQSFALTWYD--FVL--------NLWEGFTQLFF 190

  Fly   198 TKVHENNAG-------------ALKV-----IY---------GSLVLVNKVFFSLNSQDLPEFFE 235
            |.:.|.|..             :|::     ||         |.::|:..:|     |.|.:..|
Mosquito   191 TNICEQNCAIEVCASNLEKAIFSLRILKKLTIYGITDPLKSEGCMMLIRVMF-----QRLKDLLE 250

  Fly   236 DNINTWMGAFIQQLAADVPSLRTADDEDAGVLEHLRAQVCENICLYAK---KYDEEFKPFMEQFV 297
            ..:.  :...:::..::.....|..:|...::..|...:.:.|..:.|   .:.|........||
Mosquito   251 CRMR--VKRMLREAESNAAPSSTVSNEAIEIMRKLSVNLEKFIVKHMKFLNLFYETHPDVFSSFV 313

  Fly   298 TAVWELLVKTSLHTK-----YDSLV---SHALQFLSVV-------------------------AD 329
            ...:|.......|..     .|:::   :.|:|.|.::                         .:
Mosquito   314 AVSFEFCFNYVFHEGTNLIFEDNVITFPNFAIQCLCLLKGILSPNTLKLDVLPRVSNYLAGEAKE 378

  Fly   330 RQHYQSI-FENPEILAQICDKVVIPNLDIRPSDEEIFEDSPEEYIRRDIEGSD---IDTRRRAAC 390
            |.:...: |..||.|:.|.:|:::....:.|.:.|.::..||.|  ...||.|   .:.|..|..
Mosquito   379 RVNSAKVDFFTPERLSYIFEKLIMHYFLLTPDEFEQWDTDPEGY--TSDEGGDSWKYNLRSSAEA 441

  Fly   391 DLVKTLSINFEQKIFGIFGQYLERLLTKY--KENPATNWRSKD-------TAIYLVTSWASRGGT 446
                     |...:|..|...:...|.||  |....|...:.|       .:||..|..|:
Mosquito   442 ---------FYMILFQKFSPTMIEELRKYITKSQSITLTENSDMNDLLIKDSIYNATGLAA---- 493

  Fly   447 QKHGITQTSELVPLPEFCAQQIIPELERPNINEFPVLKAAAIKYV-----MVFRSILGPQVLASC 506
                .|...| :...|:.::|::.||:..:.| |.:::...|..|     :.|...|.|||..:|
Mosquito   494 ----FTLFDE-INFDEWFSRQLLEELKFKSHN-FRIIRKRIIWLVGQWTGVRFSKALRPQVYQAC 552

  Fly   507 LPQLIRHLPAESSVVHSYAACSVEKILSMRDASNAIVFGPQILAPYTTELISGLFATLSLPGSGE 571
            | :|::  |:|...|...|:.|:..|:      :...|..:....|....::.||..|......|
Mosquito   553 L-ELLQ--PSEDLAVRLTASKSLRSIM------DDFEFVAEQFVEYLEPAVALLFGLLKEAVECE 608

  Fly   572 NE----YVMKAIMRSFSVLQSAAMPFMGVALPRLTE--------------ILTQVAKN----PSR 614
            .:    |||..|:...|:.....:..:...||.|.|              .|.|:.|.    ||.
Mosquito   609 TKMTVLYVMSFIIEKMSMSMRIDVQSLVQYLPLLWEESREHNMLRCAIISTLLQIIKALYEIPSS 673

  Fly   615 PQFNHYLFETLALCIKIVCHADSSAVSSFEEALFPVFQGILQQDIVEFMPYVFQMLSVLLEMREG 679
            .....::::.:.:...:   .|.|.|...||.|         :..|..:.|...|...||.:.|.
Mosquito   674 EPIVAFIYQIIEMSTNV---NDPSHVYLLEEGL---------ELWVVVVHYSRTMNQELLNLCEN 726

  Fly   680 TGTIPEPYWALFPCLLSPALWDRTGNVTPLIRLISAFIKQGSAQIQALGKLSGILGIFQKMIASK 744
                           |.|.:...:.|:...:.::.|::..| |::........|:...|.::...
Mosquito   727 ---------------LVPLIQQSSSNMNICLAIVQAYVFLG-AEVFLPRYGQEIVKTCQYLLTDL 775

  Fly   745 ANDHEGFYLLQNLL-----------------SYYPPAEIQTNLRQIFGLLFQRLSLSKTPKYLSG 792
            ..|  |..|:....                 |||.    |||..|:..:..|.:|     :.|..
Mosquito   776 RAD--GVVLINRFFLTLLQAVPKFAIELLRPSYYQ----QTNFPQVLQIYLQIIS-----RVLVN 829

  Fly   793 IIIFFSFYVIKFSGSQMAQLIDEIQPNLFGMLLDRV---FITEMGKIPKEQDRKMVAVGVTKLLT 854
            ..:.|| .|:..:|:|.|              |:::   ::..|.::...::||::|:.::.|||
Mosquito   830 DQVTFS-VVLAETGAQDA--------------LEKILTAWLENMRRVTAIEERKLLALALSSLLT 879

  Fly   855 ETPEILQQQYA---TFWPRLLHSLIDLFER 881
            .:.:::.:.:|   |.....|:.::|:|.:
Mosquito   880 VSNDVIYKNFAGIITNVTEALNDIMDVFSQ 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cse1	NP_523588.2	IBN_N	29..105	CDD:281761	17/75 (23%)
		Cse1	159..528	CDD:285678	91/459 (20%)
		CAS_CSE1	530..966	CDD:281384	73/397 (18%)
AgaP_AGAP002970	XP_311926.5	CSE1	4..999	CDD:227944	200/1005 (20%)
AgaP_AGAP002970	XP_311926.5	IBN_N	25..92	CDD:281761	17/70 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910