DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cse1 and cse1l

DIOPT Version :9

Sequence 1:	NP_523588.2	Gene:	Cse1 / 35016	FlyBaseID:	FBgn0022213	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	XP_012827002.1	Gene:	cse1l / 100158534	XenbaseID:	XB-GENE-5802331	Length:	1007	Species:	Xenopus tropicalis

Alignment Length:	980	Identity:	507/980 - (51%)
Similarity:	683/980 - (69%)	Gaps:	23/980 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEVTEANLQLLAGYLQQTLSADPNVRRPAEKLLESTELQQNYPILLLNLIDKAQMDMTTRVAGAI 65
            ||::|||||.|..||::||..||.|||||||.|||.|..||||:|||.|::::| |...:|..|:
Frog    37 MELSEANLQGLTEYLKKTLDPDPAVRRPAEKYLESVEGNQNYPLLLLTLVERSQ-DNVIKVCSAV 100

  Fly    66 AFKNYIKRNWAAHLDSDGPDRIHESDRNTIKTLIVTLMLHSPVALQKQLSDAVSIIGKYDFPKKW 130
            .|||||||||  .:..|.|:.|.|:||..||:.|:.|||.||..:|||.|||:||||:.|||:||
Frog   101 TFKNYIKRNW--RIIEDEPNNICEADRIAIKSSIINLMLSSPEQIQKQFSDAISIIGREDFPQKW 163

  Fly   131 PQLIDEMVERFASGDFNVINGVLQTAHSLFKRYRYEFKSQALWEEIKFVLDRMAKPLTDLLQATM 195
            |.|:.|||.||.||||:||||||.||||||||||:||||..||.|||.|||..|.|||||.:||:
Frog   164 PNLLTEMVNRFQSGDFHVINGVLHTAHSLFKRYRHEFKSSELWTEIKLVLDTFAAPLTDLFKATI 228

  Fly   196 QLTKVHENNAGALKVIYGSLVLVNKVFFSLNSQDLPEFFEDNINTWMGAFIQQLAADVPSLRTAD 260
            :|...|.|:..||||::.||:|:.|:|.|||.||||||||||:.|||..|...|..|...|:|.|
Frog   229 ELCNTHANDVNALKVLFSSLILIAKLFHSLNFQDLPEFFEDNMETWMTNFHNLLTLDNKLLQTDD 293

  Fly   261 DEDAGVLEHLRAQVCENICLYAKKYDEEFKPFMEQFVTAVWELLVKTSLHTKYDSLVSHALQFLS 325
            :|:||:||.|::|:|:|..|||:||||||:|::.:||||:|.|||.|....|||.|||:|:|||:
Frog   294 EEEAGLLETLKSQICDNAALYAQKYDEEFQPYLPRFVTAIWNLLVTTGQEVKYDLLVSNAIQFLA 358

  Fly   326 VVADRQHYQSIFENPEILAQICDKVVIPNLDIRPSDEEIFEDSPEEYIRRDIEGSDIDTRRRAAC 390
            .|.:|.||:::||:|..|..||:||::||::.|.:|||.|||:.|||||||:|||||||||||||
Frog   359 SVCERPHYKNLFEDPSTLTSICEKVIVPNMEFRAADEEAFEDNSEEYIRRDLEGSDIDTRRRAAC 423

  Fly   391 DLVKTLSINFEQKIFGIFGQYLERLLTKYKENPATNWRSKDTAIYLVTSWASRGGTQKHGITQTS 455
            |||:.|...||..:..||..|:..:|.:|.::|:.||:.||.|||||||.||:..||||||||.:
Frog   424 DLVRGLCKFFEGPVTNIFSGYVSSMLQEYAKSPSVNWKHKDAAIYLVTSLASKAQTQKHGITQAN 488

  Fly   456 ELVPLPEFCAQQIIPELERPNINEFPVLKAAAIKYVMVFRSILGPQVLASCLPQLIRHLPAESSV 520
            |||.:.||....|:|:|:..||||:|||||..|||:|.|||.|..:.|...:|.||.||.|||.|
Frog   489 ELVNITEFFVNHILPDLKSANINEYPVLKADGIKYIMFFRSQLPKEQLLVTIPLLIAHLQAESVV 553

  Fly   521 VHSYAACSVEKILSMRDASNAIVFGPQILAPYTTELISGLFATLSLPGSGENEYVMKAIMRSFSV 585
            ||:|||.::|:..:|:.|::..:.....:.||...|::.||..||||||.||||:|||||||||:
Frog   554 VHTYAAHALERFFTMKGATSPTLIVAAEMMPYVELLLANLFKALSLPGSSENEYIMKAIMRSFSL 618

  Fly   586 LQSAAMPFMGVALPRLTEILTQVAKNPSRPQFNHYLFETLALCIKIVCHADSSAVSSFEEALFPV 650
            ||.|.:|::...:.:||:.|..|:||||:|.|||||||.:.|.|:|.|.|:.:||.|||:|||.|
Frog   619 LQEAIIPYIPSVISQLTQKLLAVSKNPSKPHFNHYLFEAICLSIRITCRANPAAVGSFEDALFLV 683

  Fly   651 FQGILQQDIVEFMPYVFQMLSVLLEMREGTGTIPEPYWALFPCLLSPALWDRTGNVTPLIRLISA 715
            |..|||.|:.||:|||||::|:|||:.  ...||..|.||||.||.|.||:||||:.||:||:.|
Frog   684 FTEILQSDVQEFIPYVFQVMSLLLEIH--ANDIPTSYMALFPHLLQPVLWERTGNIPPLVRLLQA 746

  Fly   716 FIKQGSAQI--QALGKLSGILGIFQKMIASKANDHEGFYLLQNLLSYYPPAEIQTNLRQIFGLLF 778
            ::::|:..|  .|..|:.|:||:|||:||||||||:|||||.:::.:.|...|:...||||.:||
Frog   747 YLERGANTIAASASDKIPGLLGVFQKLIASKANDHQGFYLLNSIIEHLPAECIEQYKRQIFIVLF 811

  Fly   779 QRLSLSKTPKYLSGIIIFFSFYVIKFSGSQMAQLIDEIQPNLFGMLLDRVFITEMGKIPKEQDRK 843
            |||..|||.|::...::|.:.:.|||....:.::.|.|||.:|||:::::.|.|:.|:....::|
Frog   812 QRLQSSKTTKFVKSFLVFLNLFCIKFGAIALQEMFDSIQPKMFGMVVEKIIIPEIQKVSGPIEKK 876

  Fly   844 MVAVGVTKLLTETPEILQQQYATFWPRLLHSLIDLFERP-----PEKLMGLEIGETAGVAEDPDA 903
            :.|||:||:|||.|.::..:|...|..||.:||.|||.|     |:....::|.:|        .
Frog   877 ICAVGLTKVLTECPAMMDTEYTKLWTPLLQALIGLFELPEDDTIPDDEHFIDIEDT--------P 933

  Fly   904 GYQVAFAQLTHAQPNQQDHLAE-IKDARQFLATSLSKFAQARAGEFSTLLS-PLEPEYKQVLQKY 966
            |||.||:||..|...:.|.:.| :.:.:..||.||.|.:.|..|...:::| .|..:..|.||.|
Frog   934 GYQAAFSQLAFAGKKEHDPIGEMVNNPKILLAQSLHKLSTACPGRVPSMISTSLNADALQFLQGY 998

  Fly   967 CDQAG 971
            . |||
Frog   999 L-QAG 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cse1	NP_523588.2	IBN_N	29..105	CDD:281761	39/75 (52%)
		Cse1	159..528	CDD:285678	212/368 (58%)
		CAS_CSE1	530..966	CDD:281384	195/444 (44%)
cse1l	XP_012827002.1	IBN_N	65..138	CDD:197981	39/75 (52%)
		Cse1	192..562	CDD:369909	212/369 (57%)
		CAS_CSE1	563..998	CDD:367469	195/444 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	435	1.000	Domainoid score	I569
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1006
Inparanoid	1	1.050	978	1.000	Inparanoid score	I313
OMA	1	1.010	-	-		QHG53855
OrthoDB	1	1.010	-	-		D1248958at2759
OrthoFinder	1	1.000	-	-		FOG0004998
OrthoInspector	1	1.000	-	-		oto102909
Panther	1	1.100	-	-	LDO	PTHR10997
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4827
SonicParanoid	1	1.000	-	-		X3532
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110