DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17928 and FADS2

DIOPT Version :9

Sequence 1:	NP_001260515.1	Gene:	CG17928 / 35009	FlyBaseID:	FBgn0032603	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_004256.1	Gene:	FADS2 / 9415	HGNCID:	3575	Length:	444	Species:	Homo sapiens

Alignment Length:	432	Identity:	90/432 - (20%)
Similarity:	163/432 - (37%)	Gaps:	87/432 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 QHRPITSESWLEGKNVDDEAEGLWRINDTLYDLSDFAARHPGGSSWIECTRGTDITEPFESHHIE 89
            |...:.::.||.             |:..:|:::.::.:||||...|....|.|.|:.|.:.|.:
Human    27 QKHNLRTDRWLV-------------IDRKVYNITKWSIQHPGGQRVIGHYAGEDATDAFRAFHPD 78

  Fly    90 ERARGMLSKFEVRKAARP--------RNYKFTLEENGFYMTLKRRVREKLRKIDYSPTKKTEFL- 145
            ....|...|..:.....|        :|.|.|.:        .|.:|:....::...|....||
Human    79 LEFVGKFLKPLLIGELAPEEPSQDHGKNSKITED--------FRALRKTAEDMNLFKTNHVFFLL 135

  Fly   146 ---HLGILVSVFLFS-------WAGTVLDSLIF---KGLAGLALCWVATSTHNYFH----QRDSW 193
               |:..|.|:..|:       |..|::.:.:.   :..||    |:   .|:|.|    ::..|
Human   136 LLAHIIALESIAWFTVFYFGNGWIPTLITAFVLATSQAQAG----WL---QHDYGHLSVYRKPKW 193

  Fly   194 RMYTFNLTMMNFR----NWRISHALSHHVYANSLH-DLEMSMFEPFLC--WIPDSHYASKPQRLI 251
            ........:.:.:    ||.......||...|..| |.:::|...|:.  |.| ..|..|..:.:
Human   194 NHLVHKFVIGHLKGASANWWNHRHFQHHAKPNIFHKDPDVNMLHVFVLGEWQP-IEYGKKKLKYL 257

  Fly   252 S---------VVISPVVYVVLFQGQFLIRLVLSLTKRNVLCWDDL---IGFSLPIFIYLSTGVSL 304
            .         ::..|::..:.||.|.::.:::   .:|   |.||   :.:.:..||.......:
Human   258 PYNHQHEYFFLIGPPLLIPMYFQYQIIMTMIV---HKN---WVDLAWAVSYYIRFFITYIPFYGI 316

  Fly   305 LSALLSWEIIISVGSFIFGLVGLTAAHHDPRILHDGDAQRQDFDWGLYQVDTIIDRGDIKWSDLL 369
            |.|||....|..:.|..|  |.:|..:|....: |.:|.|   ||...|:....:.....::|..
Human   317 LGALLFLNFIRFLESHWF--VWVTQMNHIVMEI-DQEAYR---DWFSSQLTATCNVEQSFFNDWF 375

  Fly   370 VLTHFGEHALHHLFPTLDHGVLKHLYPELRKTMKEFDVELRE 411
             ..|......||||||:....|..:.|.::....:..:|.:|
Human   376 -SGHLNFQIEHHLFPTMPRHNLHKIAPLVKSLCAKHGIEYQE 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17928	NP_001260515.1	Cyt-b5	33..103	CDD:278597	16/69 (23%)
		Membrane-FADS-like	151..388	CDD:294412	58/269 (22%)
		FA_desaturase	171..412	CDD:278890	58/264 (22%)
FADS2	NP_004256.1	CYB5	1..432	CDD:332558	90/432 (21%)
		Delta6-FADS-like	162..412	CDD:239583	56/270 (21%)
		Histidine box-1	180..184		2/3 (67%)
		Histidine box-2	217..221		0/3 (0%)
		Histidine box-3	382..386		0/3 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	45	1.000	Inparanoid score	I5495
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1060606at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.870