DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17928 and Fads2

DIOPT Version :9

Sequence 1:	NP_001260515.1	Gene:	CG17928 / 35009	FlyBaseID:	FBgn0032603	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_062673.1	Gene:	Fads2 / 56473	MGIID:	1930079	Length:	444	Species:	Mus musculus

Alignment Length:	444	Identity:	89/444 - (20%)
Similarity:	167/444 - (37%)	Gaps:	99/444 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PSYR----QHRPITSESWLEGKNVDDEAEGLWRINDTLYDLSDFAARHPGGSSWIECTRGTDITE 81
            |::|    |...:.::.||.             |:..:|:::.::.|||||...|....|.|.|:
Mouse    19 PTFRWEEIQKHNLRTDRWLV-------------IDRKVYNVTKWSQRHPGGHRVIGHYSGEDATD 70

  Fly    82 PFESHHIEERARG------MLSKFEVRKAARPRNYKFTLEENGFYMTLKRRVREKLRKIDYSPTK 140
            .|.:.|::....|      ::.:....:.:..|.....:.|:  :..||:...:       ....
Mouse    71 AFRAFHLDLDFVGKFLKPLLIGELAPEEPSLDRGKSSQITED--FRALKKTAED-------MNLF 126

  Fly   141 KTEFLHLGILVSVFLFSWAGTVLDSLIFKGLAGLALCWV---------ATS-------THNYFH- 188
            ||..|...:|:|..:      |::||.:..|:.....|:         |||       .|:|.|
Mouse   127 KTNHLFFFLLLSHII------VMESLAWFILSYFGTGWIPTLVTAFVLATSQAQAGWLQHDYGHL 185

  Fly   189 ---QRDSWRMYTFNLTMMNFR----NWRISHALSHHVYAN---------SLHDLEMSMFEPF--- 234
               ::..|........:.:.:    ||.......||...|         |||...:..::|.
Mouse   186 SVYKKSIWNHVVHKFVIGHLKGASANWWNHRHFQHHAKPNIFHKDPDIKSLHVFVLGEWQPLEYG 250

  Fly   235 ---LCWIPDSHYASKPQRLISVVISPVVYVVLFQGQFLIRLVLSLTKRNVLCWDDL---IGFSLP 293
               |.::|.:|    ......::..|::..:.||.|.::.::   ::|:   |.||   |.:.:.
Mouse   251 KKKLKYLPYNH----QHEYFFLIGPPLLIPMYFQYQIIMTMI---SRRD---WVDLAWAISYYMR 305

  Fly   294 IFIYLSTGVSLLSALLSWEIIISVGSFIFGLVGLTAAHHDPRILH-DGDAQRQDFDWGLYQVDTI 357
            .|........:|.||:....|..:.|..|  |.:|..:|  .::. |.|..|   ||...|:...
Mouse   306 FFYTYIPFYGILGALVFLNFIRFLESHWF--VWVTQMNH--LVMEIDLDHYR---DWFSSQLAAT 363

  Fly   358 IDRGDIKWSDLLVLTHFGEHALHHLFPTLDHGVLKHLYPELRKTMKEFDVELRE 411
            .:.....::|.. ..|......||||||:....|..:.|.::....:..:|.:|
Mouse   364 CNVEQSFFNDWF-SGHLNFQIEHHLFPTMPRHNLHKIAPLVKSLCAKHGIEYQE 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17928	NP_001260515.1	Cyt-b5	33..103	CDD:278597	16/75 (21%)
		Membrane-FADS-like	151..388	CDD:294412	58/279 (21%)
		FA_desaturase	171..412	CDD:278890	58/284 (20%)
Fads2	NP_062673.1	PLN03199	1..439	CDD:178740	89/444 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		1/1 (100%)
		Cyt-b5	20..94	CDD:278597	18/86 (21%)
		Delta6-FADS-like	162..412	CDD:239583	54/267 (20%)
		Histidine box-1	180..184		2/3 (67%)
		Histidine box-2	217..221		0/3 (0%)
		Histidine box-3	382..386		0/3 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	56	1.000	Inparanoid score	I5430
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1060606at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.870