DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17928 and Fads3

DIOPT Version :9

Sequence 1:	NP_001260515.1	Gene:	CG17928 / 35009	FlyBaseID:	FBgn0032603	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_775160.1	Gene:	Fads3 / 286922	RGDID:	628876	Length:	449	Species:	Rattus norvegicus

Alignment Length:	425	Identity:	95/425 - (22%)
Similarity:	152/425 - (35%)	Gaps:	89/425 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RQHRPITSESWLEGKNVDDEAEGLWRINDTLYDLSDFAARHPGGSSWIECTRGTDITEPFESHHI 88
            ||| .:..:.||.             |...:||:|.:|.||||||..|......|.|:.|.:.|.
  Rat    33 RQH-DLPGDKWLV-------------IERRVYDISRWAQRHPGGSRLIGHHSAEDATDAFHAFHQ 83

  Fly    89 E-ERARGMLSKFEVRKAARPRNYKFTLEENGFYMTLKRRVREKLRKIDYSPTKKTEF-LHLGILV 151
            : ...|..|....:.:.| |........:|...:...|.:|:....:.......|.| |.||.::
  Rat    84 DLHFVRKFLKPLLIGELA-PEEPSQDGAQNAQLIEDFRALRQAAEDMKLFEADTTFFALLLGHIL 147

  Fly   152 SVFLFS----------WAGTVLDSLIFKGLAGLALCWVATSTHNYFH----QRDSWRMYTFNLTM 202
            ::.|.:          |..:||.:||.  ....|.||..  .|:..|    .:..|........|
  Rat   148 AMELLAWLLVYLLGPGWVSSVLAALIL--AISQAQCWCL--QHDLGHASIFPKSRWNHVAQQFVM 208

  Fly   203 MNFRN-----WRISHALSHHVYANSLH-DLEMSMFEPFLCWIPDSHYASKPQRLIS--------- 252
            ...:.     |...| ..||...|..| |.::::...||.......|..|.:|.:.
  Rat   209 GQLKGFSAHWWNFRH-FQHHAKPNIFHKDPDVTVAPVFLLGESSVEYGKKKRRYLPYNHQHLYFF 272

  Fly   253 VVISPVVYVVLFQGQFLIRLVLSLTKRNVLCWDDLI---GFSLPIFIYLSTGVSLLSALLSWEII 314
            ::..|::.:|.|:.:.|..:::.:.      |.||:   .|....|:..|........||.:..:
  Rat   273 LIGPPLLTLVNFEVENLAYMLVCMQ------WTDLLWAASFYSRFFLSYSPFYGATGTLLLFVAV 331

  Fly   315 ISVGSFIFGLVGLTAAHHDPR-ILHDGDAQRQDFDWGLYQV--------DTIIDRGDIKWSDLLV 370
            ..:.|..|  |.:|..:|.|: |.|:     :..||...|:        ...||     |..
  Rat   332 RVLESHWF--VWITQMNHIPKEIGHE-----KHRDWASSQLAATCNVEPSLFID-----WFS--- 381

  Fly   371 LTHFGEHALHHLFPTLDHGVLKHLYPELRKTMKEF 405
             .|......||||||:.    :|.|..:...:|.|
  Rat   382 -GHLNFQIEHHLFPTMP----RHNYRRVAPLVKAF 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17928	NP_001260515.1	Cyt-b5	33..103	CDD:278597	20/70 (29%)
		Membrane-FADS-like	151..388	CDD:294412	58/277 (21%)
		FA_desaturase	171..412	CDD:278890	56/266 (21%)
Fads3	NP_775160.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		PLN03199	27..444	CDD:178740	95/425 (22%)
		Delta6-FADS-like	168..417	CDD:239583	60/275 (22%)
		Histidine box-1. /evidence=ECO:0000250\|UniProtKB:Q9Y5Q0	186..190		1/3 (33%)
		Histidine box-2. /evidence=ECO:0000250\|UniProtKB:Q9Y5Q0	223..227		1/4 (25%)
		Histidine box-3. /evidence=ECO:0000250\|UniProtKB:Q9Y5Q0	387..391		0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	56	1.000	Inparanoid score	I5335
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1060606at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.870