DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17928 and fads2

DIOPT Version :9

Sequence 1:	NP_001260515.1	Gene:	CG17928 / 35009	FlyBaseID:	FBgn0032603	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_571720.2	Gene:	fads2 / 140615	ZFINID:	ZDB-GENE-011212-1	Length:	444	Species:	Danio rerio

Alignment Length:	470	Identity:	93/470 - (19%)
Similarity:	161/470 - (34%)	Gaps:	133/470 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 RVSGISRNYPSYRQHRPITSESWLEGKNVDDEAEGLWRINDTLYDLSDFAARHPGGSSWIECTRG 76
            |::..:..:.||         :|.|.:......:....:...:|::|.:..|||||...:....|
Zfish    10 RITDTNGRFSSY---------TWEEMQKHTKHGDQWVVVERKVYNVSQWVKRHPGGLRILGHYAG 65

  Fly    77 TDITEPFESHH-----IEERARGML-SKFEVRKAARPRNYKFTLEENGFYMTLKRRVREKLRKID 135
            .|.||.|.:.|     :.:..:.:| .:.|..:.::.|.....|.|:      .|.:||:|....
Zfish    66 EDATEAFTAFHPNLQLMRKYLKPLLIGELEASEPSQDRQKNAALVED------FRALRERLEAEG 124

  Fly   136 YSPTKKTEF-LHLG----------ILVSVFLFSWAGTVLDSLIF---KGLAGLALCWVATSTHNY 186
            ...|:...| ||||          ::|..|...|..|::.::|.   :..||    |:
Zfish   125 CFKTQPLFFALHLGHILLLEAIAFVMVWYFGTGWINTLIVAVILATAQSQAG----WL------- 178

  Fly   187 FHQRDSWRMYTFNLTMMNF--------------RNWRISHALSHHVYANSL-HDLEMSMFEPFLC 236
              |.|...:..|..:.||.              ..|.......||...|.. .|.:::|...|:.
Zfish   179 --QHDFGHLSVFKTSGMNHLVHKFVIGHLKGASAGWWNHRHFQHHAKPNIFKKDPDVNMLNAFVV 241

  Fly   237 --------------WIPDSHYASKPQRLISVVISPVVYVVLFQGQFLIRLV-----------LSL 276
                          .:|.:|    ..:....:..|::..|.||.|....::           :|.
Zfish   242 GNVQPVEYGVKKIKHLPYNH----QHKYFFFIGPPLLIPVYFQFQIFHNMISHGMWVDLLWCISY 302

  Fly   277 TKRNVLCWDDLIGFSLPIFIYLSTGVSLLSALLSWEIIISVGSFIFGLVGLTAAH------HDPR 335
            ..|..||:....|    :|               |.||      :|..|....:|      ...|
Zfish   303 YVRYFLCYTQFYG----VF---------------WAII------LFNFVRFMESHWFVWVTQMSR 342

  Fly   336 ILHDGDAQRQDFDWGLYQVDTIIDRGDIKWSDLLVLTHFGEHALHHLFPTLDHGVLKHLY----P 396
            |..:.|.: |:.||...|:....:.....::|.. ..|......||||||:.    :|.|    |
Zfish   343 IPMNIDYE-QNQDWLSMQLVATCNIEQSAFNDWF-SGHLNFQIEHHLFPTMP----RHNYWRAAP 401

  Fly   397 ELRKTMKEFDVELRE 411
            .:|...:::.|:.:|
Zfish   402 RVRSLCEKYGVKYQE 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17928	NP_001260515.1	Cyt-b5	33..103	CDD:278597	17/75 (23%)
		Membrane-FADS-like	151..388	CDD:294412	54/285 (19%)
		FA_desaturase	171..412	CDD:278890	55/291 (19%)
fads2	NP_571720.2	PLN03199	21..439	CDD:178740	91/459 (20%)
		Cyt-b5	21..94	CDD:278597	17/81 (21%)
		Delta6-FADS-like	162..412	CDD:239583	54/297 (18%)
		Histidine box-1	180..184		1/3 (33%)
		Histidine box-2	217..221		0/3 (0%)
		Histidine box-3	382..386		0/3 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1060606at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820