DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyt-b5-r and FADS2

DIOPT Version :9

Sequence 1:	NP_001260514.1	Gene:	Cyt-b5-r / 35008	FlyBaseID:	FBgn0000406	Length:	436	Species:	Drosophila melanogaster
Sequence 2:	NP_004256.1	Gene:	FADS2 / 9415	HGNCID:	3575	Length:	444	Species:	Homo sapiens

Alignment Length:	479	Identity:	105/479 - (21%)
Similarity:	171/479 - (35%)	Gaps:	153/479 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ITTHSWQKGKRQDDGAEGLWRINDGIYDFTSFIDKHPGGPFWIRETKGTDITEAFEAHHLTTAPE 88
            :.|.||::.::.:...:....|:..:|:.|.:..:||||...|....|.|.|:||.|.|    |:
Human    18 VPTFSWEEIQKHNLRTDRWLVIDRKVYNITKWSIQHPGGQRVIGHYAGEDATDAFRAFH----PD 78

  Fly    89 -----KMIAKYKVRDAA--EPRIYTLTLEEGGFYKTLKERVREQLKTIDKRPKKKSDLIHLGLVV 146
                 |.:....:.:.|  ||.      ::.|....:.|..|...||.:.....|::.:
Human    79 LEFVGKFLKPLLIGELAPEEPS------QDHGKNSKITEDFRALRKTAEDMNLFKTNHV------ 131

  Fly   147 SLYLLGIASAKYNSLLALVLASVALCWTVI--------------------------VSHNYFH-- 183
             .:||         |||.::|..::.|..:                          :.|:|.|
Human   132 -FFLL---------LLAHIIALESIAWFTVFYFGNGWIPTLITAFVLATSQAQAGWLQHDYGHLS 186

  Fly   184 --RRDNWQ--MYAFNLGMMNFAA---WRVSHALSHHIYPNSYF-DLELSMFEPLLC--WVPNPHI 238
              |:..|.  ::.|.:|.:..|:   |...| ..||..||.:. |.:::|....:.  |.|..:.
Human   187 VYRKPKWNHLVHKFVIGHLKGASANWWNHRH-FQHHAKPNIFHKDPDVNMLHVFVLGEWQPIEYG 250

  Fly   239 KSKLMRYVSWVTEPVAYALAFFIQMGTRIF------YSLRHTNILY--WHDL---LPLTIPIAI- 291
            |.|| :|:     |..:...:|..:|..:.      |.:..|.|::  |.||   :...|...|
Human   251 KKKL-KYL-----PYNHQHEYFFLIGPPLLIPMYFQYQIIMTMIVHKNWVDLAWAVSYYIRFFIT 309

  Fly   292 YLGTGGSLGIWICVRQWLAMTSIASF--SFCLIGLNAAHH-----DPEIYHEGDANREDRDWGLF 349
            |:...|.||.       |...:...|  |...:.:...:|     |.|.|         |||
Human   310 YIPFYGILGA-------LLFLNFIRFLESHWFVWVTQMNHIVMEIDQEAY---------RDW--- 355

  Fly   350 QVDTIIDRGDLKWSQFLVLT--------------HFGDHVLHHLFPTLDHGLLPALYPVLYQTLD 400
                        :|..|..|              |....:.||||||:....|..:.| |.::|.
Human   356 ------------FSSQLTATCNVEQSFFNDWFSGHLNFQIEHHLFPTMPRHNLHKIAP-LVKSLC 407

  Fly   401 EFKGHLRECNHIEHMIGQHKQLLR 424
            ...|       ||:   |.|.|||
Human   408 AKHG-------IEY---QEKPLLR 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyt-b5-r	NP_001260514.1	Cyt-b5	26..98	CDD:278597	20/76 (26%)
		FA_desaturase	161..408	CDD:278890	67/317 (21%)
		Membrane-FADS-like	<328..385	CDD:294412	17/75 (23%)
FADS2	NP_004256.1	CYB5	1..432	CDD:332558	105/479 (22%)
		Delta6-FADS-like	162..412	CDD:239583	62/295 (21%)
		Histidine box-1	180..184		2/3 (67%)
		Histidine box-2	217..221		1/4 (25%)
		Histidine box-3	382..386		0/3 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	45	1.000	Inparanoid score	I5495
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1060606at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.870