DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyt-b5-r and Fads1

DIOPT Version :9

Sequence 1:	NP_001260514.1	Gene:	Cyt-b5-r / 35008	FlyBaseID:	FBgn0000406	Length:	436	Species:	Drosophila melanogaster
Sequence 2:	XP_006231137.1	Gene:	Fads1 / 84575	RGDID:	621678	Length:	471	Species:	Rattus norvegicus

Alignment Length:	476	Identity:	94/476 - (19%)
Similarity:	170/476 - (35%)	Gaps:	160/476 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SWQKGKRQDDGAEGLWRIND-GIYDFTSFIDKHPGGPFWIRETKGTDITEAFEAHHLTTAPEKMI 91
            :|::..::....:..|.:.| .:|:.:.|..:||||...|....|.|.|:.|.|.|:.   :.::
  Rat    23 TWEEVAQRSGREKERWLVIDRKVYNISDFSRRHPGGSRVISHYAGQDATDPFVAFHIN---KGLV 84

  Fly    92 AKYKVRDAAEPRIYTLTLEEGGF----------------------------YKTLKERVREQLKT 128
            .||    .....|..|..|:..|                            .|.|.:..||...|
  Rat    85 RKY----MNSLLIGELAPEQPSFEPTKNLPPWEVLFKGWGATEKNSSPCLPQKALTDEFRELRAT 145

  Fly   129 IDKRPKKKSD-------LIHLGLV-----VSLYLLGIASAKYNSLLALVLASV--ALCWTVIVSH 179
            :::....|::       |:|:.|:     ::|::.|.:...: :|.|::|::|  ...|   :.|
  Rat   146 VERMGLMKANHLFFLFYLLHILLLDVAAWLTLWIFGTSLVPF-TLCAVLLSTVQAQAGW---LQH 206

  Fly   180 NYFH----RRDNWQ--MYAFNLGMMNFAA---WRVSHALSHHIYPNSY-FDLELSMFEPL----- 229
            ::.|    ....|.  ::.|.:|.:..|.   |...| ..||..||.: .|.:::| .||
  Rat   207 DFGHLSVFSTSTWNHLVHHFVIGHLKGAPASWWNHMH-FQHHAKPNCFRKDPDINM-HPLFFALG 269

  Fly   230 -LCWVPNPHIKSKLMRY-------------------------------VSWVTEPVAYALAFFIQ 262
             :..|.....|.|.|.|                               ..||  .:|:.|:|::
  Rat   270 KVLSVELGKEKKKHMPYNHQHKYFFLIGPPALLPLYFQWYIFYFVVQRKKWV--DLAWMLSFYV- 331

  Fly   263 MGTRIFYSLRHTNILYWHDLLPLTIPIAIYLGTGGSLGIWICVR----QWLAMTSIASFSFCLIG 323
               |:|::           .:||       ||..|.|.::..||    .|            .:.
  Rat   332 ---RVFFT-----------YMPL-------LGLKGLLCLFFIVRFLESNW------------FVW 363

  Fly   324 LNAAHHDP-EIYHEGDANREDRDWGLFQVDTIIDRGDLKWSQFLVLTHFGDHVLHHLFPTLD--- 384
            :...:|.| .|.|:.:.     ||...|:....:.....::.:. ..|....:.||||||:.
  Rat   364 VTQMNHIPMHIDHDRNV-----DWVSTQLQATCNVHQSAFNNWF-SGHLNFQIEHHLFPTMPRHN 422

  Fly   385 -HGLLP------ALYPVLYQT 398
             |.:.|      |.|.:.|::
  Rat   423 YHKVAPLVQSLCAKYGIKYES 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyt-b5-r	NP_001260514.1	Cyt-b5	26..98	CDD:278597	18/70 (26%)
		FA_desaturase	161..408	CDD:278890	61/302 (20%)
		Membrane-FADS-like	<328..385	CDD:294412	14/61 (23%)
Fads1	XP_006231137.1	PLN03199	12..466	CDD:178740	94/476 (20%)
		Cyt-b5	21..96	CDD:278597	19/79 (24%)
		Delta6-FADS-like	189..439	CDD:239583	60/296 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	56	1.000	Inparanoid score	I5335
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1060606at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.870