Protein Alignment Cyt-b5-r and FADS1

DIOPT Version :9

• Sequence 1: NP_001260514.1
• Gene: Cyt-b5-r / 35008
• FlyBaseID: FBgn0000406
• Length: 436
• Species: Drosophila melanogaster
• Sequence 2: NP_037534.5
• Gene: FADS1 / 3992
• HGNCID: 3574
• Length: 501
• Species: Homo sapiens
• Alignment Length: 472
• Identity: 103/472 - (21%)
• Similarity: 176/472 - (37%)
• Gaps: 107/472 - (22%)

  Fly    12 ATKFPTYRNSALITTHSWQKGKRQDDGAEGLWRIND-GIYDFTSFIDKHPGGPFWIRETKGTDIT 75
            |.:.||.|      ..:|.: ..|..|.|..|.:.| .:|:.:.|..:||||...|....|.|.|
Human    68 AAQGPTPR------YFTWDE-VAQRSGCEERWLVIDRKVYNISEFTRRHPGGSRVISHYAGQDAT 125

  Fly    76 EAFEAHHLTTAPEKMIAKYKVRDAAEPRIYTLTLEEGGF----YKTLKERVREQLKTIDKRPKKK 136
            :.|.|.|:.   :.::.||    .....|..|:.|:..|    .|.|.:..||...|:::....|
Human   126 DPFVAFHIN---KGLVKKY----MNSLLIGELSPEQPSFEPTKNKELTDEFRELRATVERMGLMK 183

  Fly   137 SD-------LIHLGLV-----VSLYLLGIASAKYNSLLALVLASVALCWTVIVSHNYFH----RR 185
            ::       |:|:.|:     ::|::.|.:...:  ||..||.|........:.|::.|    ..
Human   184 ANHVFFLLYLLHILLLDGAAWLTLWVFGTSFLPF--LLCAVLLSAVQAQAGWLQHDFGHLSVFST 246

  Fly   186 DNWQ--MYAFNLGMMNFAA---WRVSHALSHHIYPNSYF---DLELSMFEPLLCWVPNPHIKSKL 242
            ..|.  ::.|.:|.:..|.   |...| ..||..||.:.   |:.:..|...|..:.:..:..:.
Human   247 SKWNHLLHHFVIGHLKGAPASWWNHMH-FQHHAKPNCFRKDPDINMHPFFFALGKILSVELGKQK 310

  Fly   243 MRYVSWVTEPVAYALAFFIQMGT----------RIFYSLRHTNILYWHDLL-PLTIPIAIY---- 292
            .:|:     |..:...:|..:|.          .|||.:....  .|.||. .:|..:..:
Human   311 KKYM-----PYNHQHKYFFLIGPPALLPLYFQWYIFYFVIQRK--KWVDLAWMITFYVRFFLTYV 368

  Fly   293 --LGTGGSLGIWICVR----QWLAMTSIASFSFCLIGLNAAHHDP-EIYHEGDANREDRDWGLFQ 350
              ||....||::..||    .|            .:.:...:|.| .|.|:     .:.||...|
Human   369 PLLGLKAFLGLFFIVRFLESNW------------FVWVTQMNHIPMHIDHD-----RNMDWVSTQ 416

  Fly   351 VDTIIDRGDLKWSQFLVLTHFGDHVLHHLFPTLD----HGLLP------ALYPVLYQTLDEFKGH 405
            :....:.....::.:. ..|....:.||||||:.    |.:.|      |.:.:.||:    |..
Human   417 LQATCNVHKSAFNDWF-SGHLNFQIEHHLFPTMPRHNYHKVAPLVQSLCAKHGIEYQS----KPL 476

  Fly   406 LRECNHIEHMIGQHKQL 422
            |.....|.|.:.:..||
Human   477 LSAFADIIHSLKESGQL 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyt-b5-r	NP_001260514.1	Cyt-b5	26..98	CDD:278597	21/72 (29%)
		FA_desaturase	161..408	CDD:278890	59/290 (20%)
		Membrane-FADS-like	<328..385	CDD:294412	14/61 (23%)
FADS1	NP_037534.5	PRK07003	<3..>75	CDD:235906	3/6 (50%)
		PLN03199	74..496	CDD:178740	100/466 (21%)
		Delta6-FADS-like	218..469	CDD:239583	55/276 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	45	1.000	Inparanoid score	I5495
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1060606at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.870